Functional outcome at school age of neonatal post-hemorrhagic ventricular dilatation

Holwerda, Janyte C.; Braeckel, Koenraad N.J.A. Van; Roze, Elise; Hoving, Eelco W.; Maathuis, Carel G. B.; Brouwer, Oebele F.; Martijn, Albert; Bos, Arend F.

doi:10.1016/j.earlhumdev.2016.02.005

Cited by 29 publications

(34 citation statements)

References 27 publications

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“…Holwerda JC et al stressed the importance of focusing on the long term functional outcomes, which includes visual motor integration, executive function, motor skills and behavioural outcome among this cohort of patients. Results of the study showed that functional deficits were more prominent in children that had post-haemorrhagic ventricular dilatation in comparison with a normal population [29].A paper published in 2012 by Lacy M et al, mentioned that children with hydrocephalus had executive function dysfunction when compared with healthy peers. Furthermore, parents of children with hydrocephalus noted that executive function deficit among their child were more obvious as age increases [18].…”

mentioning

confidence: 90%

“…For example, a study published by Holwerda JC et al in May 2016 highlighted the importance of following up in patients who had hydrocephalus secondary to ventricular bleed [29]. Currently, there are studies that focus on the developmental and neuropsychological outcomes in preschool age.…”

Section: Introductionmentioning

confidence: 99%

“…Hydrocephalus mostly revolves around a complex The degree of long-term cognitive dysfunction varies from individual to individual. It is thought that the severity of it is dependent on the causal mechanisms of hydrocephalus and any accompanying brain dysmorphology [16].For example, a study published by Holwerda JC et al in May 2016 highlighted the importance of following up in patients who had hydrocephalus secondary to ventricular bleed [29]. Currently, there are studies that focus on the developmental and neuropsychological outcomes in preschool age.…”

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confidence: 99%

“…Most studies showed patients that had hydrocephalus secondary to ventricular bleed during the neonatal period had a poorer performance IQ rather than verbal IQ [33][34][35]. Furthermore, it is noted that children that required surgical intervention is associated with lower IQ [29]. Holwerda JC et al stressed the importance of focusing on the long term functional outcomes, which includes visual motor integration, executive function, motor skills and behavioural outcome among this cohort of patients.…”

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confidence: 99%

“…However, the results are thought to be unreliable [29][30][31][32]. There are also studies that concentrate on the outcome at school age; however they focus mainly on IQ [29]. Most studies showed patients that had hydrocephalus secondary to ventricular bleed during the neonatal period had a poorer performance IQ rather than verbal IQ [33][34][35].…”

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confidence: 99%

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Will electronic integrated text, visual and audio questionnaire be a better tool to evaluate the health status of paediatric hydrocephalus patients?

Tan¹,

Caird²,

Cooper³

2017

Ment Health Addict Res

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confidence: 90%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Will electronic integrated text, visual and audio questionnaire be a better tool to evaluate the health status of paediatric hydrocephalus patients?

Tan¹,

Caird²,

Cooper³

2017

Ment Health Addict Res

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Glycogen Synthase Kinase-3β Inhibitor VP3.15 Ameliorates Neurogenesis, Neuronal Loss and Cognitive Impairment in a Model of Germinal Matrix-intraventricular Hemorrhage of the Preterm Newborn

Atienza-Navarro,

del Marco,

Alves-Martinez

et al. 2024

Transl. Stroke Res.

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Advances in neonatology have significantly reduced mortality rates due to prematurity. However, complications of prematurity have barely changed in recent decades. Germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most severe complications of prematurity, and these children are prone to suffer short- and long-term sequelae, including cerebral palsy, cognitive and motor impairments, or neuropsychiatric disorders. Nevertheless, GM-IVH has no successful treatment. VP3.15 is a small, heterocyclic molecule of the 5-imino-1,2,4-thiadiazole family with a dual action as a phosphodiesterase 7 and glycogen synthase kinase-3β (GSK-3β) inhibitor. VP3.15 reduces neuroinflammation and neuronal loss in other neurodegenerative disorders and might ameliorate complications associated with GM-IVH. We administered VP3.15 to a mouse model of GM-IVH. VP3.15 reduces the presence of hemorrhages and microglia in the short (P14) and long (P110) term. It ameliorates brain atrophy and ventricle enlargement while limiting tau hyperphosphorylation and neuronal and myelin basic protein loss. VP3.15 also improves proliferation and neurogenesis as well as cognition after the insult. Interestingly, plasma gelsolin levels, a feasible biomarker of brain damage, improved after VP3.15 treatment. Altogether, our data support the beneficial effects of VP3.15 in GM-IVH by ameliorating brain neuroinflammatory, vascular and white matter damage, ultimately improving cognitive impairment associated with GM-IVH.

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Functioning of the children with hydrocephalus

Szefczyk-Polowczyk

Mandera

2020

Acta Neurol Belg

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The objective of the study was to examine selected aspects of the functioning of children treated for hydrocephalus, with particular emphasis on their degree of independence. Analysis of the medical records of patients treated for hydrocephalus in the Department of Pediatric Neurosurgery in Katowice in 2000-2010. The Barthel scale was used to assess the children's independence. Information on the children's functioning was obtained directly from their parents using a questionnaire developed by the author. The parent group comprised 131 people, including 110 women (85%) and 21 men (15%). The study group comprised 131 children treated for hydrocephalus. In the examined group, 59 children (45%) were fully independent (first degree), 44 (34%) were partially independent (second degree) and 28 (21%) were completely dependent (third degree). Most of the children with congenital and post-inflammatory hydrocephalus attended the generally accessible school (public school), while the majority of the children with posthemorrhagic hydrocephalus attended rehabilitation and educational centers or special schools (p < 0.05) The lowest level of independence was found for children with hemorrhagic hydrocephalus who had undergone repeated operations. The child's degree of independence and the etiology of hydrocephalus determined the type of school the child attended. The study's results indicate that rehabilitation plays a key role in the lives of children with hydrocephalus.

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Functional outcome at school age of neonatal post-hemorrhagic ventricular dilatation

Cited by 29 publications

References 27 publications

Will electronic integrated text, visual and audio questionnaire be a better tool to evaluate the health status of paediatric hydrocephalus patients?

Will electronic integrated text, visual and audio questionnaire be a better tool to evaluate the health status of paediatric hydrocephalus patients?

Glycogen Synthase Kinase-3β Inhibitor VP3.15 Ameliorates Neurogenesis, Neuronal Loss and Cognitive Impairment in a Model of Germinal Matrix-intraventricular Hemorrhage of the Preterm Newborn

Functioning of the children with hydrocephalus

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