Functional outcome and quality of life in anorectal malformations

Goyal, Anju; Williams, Janice M.; Kenny, Simon E.; Lwin, Rebecca; Baillie, Colin; Lamont, Gillian M.; Turnock, R. R.

doi:10.1016/j.jpedsurg.2005.11.006

Cited by 52 publications

(39 citation statements)

References 18 publications

(26 reference statements)

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“…O impacto do nascimento de uma criança mal formada é profundo, aliado ao problema da imperfuração anal inclui, aos pais e familiares, o desapontamento, a vergonha, os complexos de culpa, acusações mútuas, rejeições, preocupações financeiras e o medo das futuras gestações (3)(4)7) . A imperfuração anal é uma das anomalias anorretais e está associadas aos defeitos em outros sistemas do corpo (3,8) , e estudos mostram a associação mais frequente com o trato urogenital (9)(10)(11)(12)(13)(14) ; a sobrevida depende da severidade das anomalias associadas.…”

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“…As malformações congênitas incluem as anomalias presentes no momento do nascimento, as morfológicas (malformações, deformidades) ou funcionais (retardo mental, cegueira, surdez). Sua etiologia pode ser genética ou ambiental e na maioria dos casos existe uma multifatoridade que se interrelaciona; são os fatores genéticos predisponentes e fatores ambientais desencadeantes (3)(4) . Uma das anomalias congênitas que podem ocorrer é o nascimento da criança com ânus imperfurado e, por isso, em muitos casos, há a necessidade da realização de estomias.…”

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Anomalia anorretal e cuidados maternos

Melo

Kamada

2011

Rev. Bras. Enferm.

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ABSTRACT ABSTRACT ABSTRACT This purpose of the article was to make a bibliographic review about anorectal malformations and maternal cares. The matter was addressed through an integrative review undertaken in consultation of articles published in the databases indexed in the Virtual Health Library. We identified 25 publications that met the inclusion and exclusion criteria pre-established. In the studies reviewed, there were different study designs, demonstrating that some children born with anorectal anomalies requiring urgent surgery. Health professionals, along with the parents, need to develop partnerships that would enable a long-term monitoring and careful guidance. It is necessary to do more research on the subject, with methodological proposals that reflect the essence of the best care of an ostomized child. K K K K Key wor ey wor ey wor ey wor ey words: ds: ds: ds: ds: Ostomy; Infant care; Nursing RESUMEN RESUMEN RESUMEN RESUMEN RESUMEN El objetivo de este artículo fue realizar un estudio de revisión bibliográfica sobre anomalía ano retal y cuidados maternos. El asunto fue abordado por medio de una revisión integral realizada por consulta de artículos publicados en las bases de datos indexados en la Biblioteca Virtual en Salud. Fueron identificadas 25 publicaciones que atendieron a los criterios de inclusión y exclusión pre-establecidos. En los estudios analizados se observaron distintos dibujos metodológicos demostrando que algunos niños nacidos con anomalía ano retal necesitan de cirugía de urgencia. Los profesionales de salud, juntamente con los padres, necesitan desarrollar grupos que posibiliten un acompañamiento a largo plazo y orientaciones cuidadosas. Se hace necesario que nuevos estudios sean realizados sobre el tema, con propuestas metodológicas que retraten mejor la esencia del cuidado con los niños con ostomía.

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Anomalia anorretal e cuidados maternos

Melo

Kamada

2011

Rev. Bras. Enferm.

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“…6 For most, this means being able to actively participate in their social environment without significant limitations from bowel function, for which fecal continence is a major determinant. [7][8][9] Posterior sagittal anorectoplasty (PSARP), first introduced by De Vries and Peña and followed later by its limited modification anterior sagittal anorectoplasty (ASARP), represents the basis of the modern surgical approach to ARMs with termination of the anal canal outside the voluntary sphincter complex. 10,11 The outcome for patients with ARM is related to the severity of the anomaly.…”

Section: Introductionmentioning

confidence: 99%

Assessment of post-surgical functional outcome in children with anorectal malformation

Patel¹,

Ma²,

Sharma³

et al. 2018

Int Surg J

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Background: Anorectal malformations (ARMs) comprise a spectrum of congenital anomalies that continue to present a challenge for paediatric surgeons. Advances in modern surgical techniques and neonatal care have greatly improved survival among ARM patients over the last decades, and early mortality is now unusual in the absence of fatal associated cardiac or chromosomal defects. The aim of this study is to measure the functional outcome of ARM by most recent krickenburg classification.Methods: The present longitudinal study was conducted in Department of paediatric surgery, Dr. BRAM hospital, Raipur, Chhattisgarh during study period February 2016 to September 2017. Those patients who had completed their all stages of surgery for anorectal malformation at-least 6 months back and arriving at outpatient department of paediatric surgery were included.Results: Maximum number of patients were in age group of 3 to 5 years (77.8%) and minimum were 9 to 11 years (3.7%). A 50.6% male and 49.4% female child were included in the study. Maximum number of patients had vestibular fistula (38.27% followed by perineal fistula (24.69%), rectobulbar (18.51%) then rectovaginal (7.4%) and rectoprostatic (7.4%). Minimum patients had pouch colon (2.4%) and cloaca (1.09%). Voluntary bowel movement was present in 50% of rectoprostatic and 66.6% of rectovaginal fistula. Eighty percentage rectobulbar and 83.87% vestibular fistula had voluntary bowel movement. Cloaca and Pouch colon had no voluntary bowel movement. In recto-vaginal fistula 66.6% had soiling, of which 50% had grade 1 and 16.6% had grade 2 soiling. In recto-bulbar fistula 40% cases had soiling, out of which 20% had grade1 and 20% had grade 2. In recto-vaginal fistula cases 33 % had constipation, of which 16.5% had grade 1 and 16.6 % had grade 2. In recto-prostatic fistula 16% had constipation which was grade1.Conclusions: In this study, author showed that functional outcomes comparable to matched peers are achieved in the majority of low ARMs after minimally invasive, individualized perineal procedures and regular surgical follow-up. In high type of ARM soiling is the prominent feature while in intermediate ARM constipation is more common.

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“…1 Though there have been many advances in the surgical and medical care of infants with ARMs, problems that severely influence quality of life, such as constipation, soiling and incontinence, remain even after a successful operation. 2 The pathogenesis of ARMs is complicated and not well understood. At present, two categories of ARMs are recognized.…”

Section: Introductionmentioning

confidence: 99%

Down-Regulation of SHH/BMP4 Signalling in Human Anorectal Malformations

Zhang

Gao

et al. 2009

J Int Med Res

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The sonic hedgehog homologue (SHH)/bone morphogenetic protein 4 (BMP4) signalling pathway is involved in the morphogenesis of many organ systems. This study was designed to investigate the expression of SHH/BMP4 pathway components in human anorectal malformations (ARMs) and the relationship between expression of their genes and the occurrence of ARMs. Expression of SHH, GLI family zinc finger 2 (GLI2) and BMP4 mRNA in the posterior wall of the terminal rectum in 40 patients with ARMs (15 high-type and 25 low-type) and 10 normal controls was assessed by reverse transcription-polymerase chain reaction. Levels of SHH, GLI2 and BMP4 proteins were assessed by immunohistochemistry and Western blotting. The expressions of SHH, GLI2 and BMP4 were significantly lower in patients with hightype compared with those with low-type anomalies and controls. Patients with lowtype ARMs differed from controls only in the expression of GLI2 mRNA. It is concluded that down-regulation of the SHH/BMP4 signalling pathway may be related to the occurrence of high-type ARMs, but the mechanism responsible for low-type ARMs remains unclear.

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Functional outcome and quality of life in anorectal malformations

Cited by 52 publications

References 18 publications

Anomalia anorretal e cuidados maternos

Anomalia anorretal e cuidados maternos

Assessment of post-surgical functional outcome in children with anorectal malformation

Down-Regulation of SHH/BMP4 Signalling in Human Anorectal Malformations

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