Functional outcome after trypan blue–assisted vitrectomy for macular pucker: a prospective, randomized, comparative trial

Haritoglou, Christos; Eibl, K.; Schaumberger, Markus; Mueller, A. J.; Priglinger, Siegfried; Alge, Claudia S.

doi:10.1016/j.ajo.2004.03.005

Cited by 95 publications

(55 citation statements)

References 27 publications

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“…20,28 Osmolality and pH of the Trypan blue solution Trypan blue has been used for ERM peeling and ILM peeling in concentrations varying from 0.06 to 0.2%. 5,6,[8][9][10][11][29][30][31] None of these concentrations were reported as toxic in clinical practice. Haritoglou et al 5 found visions 6 months after ERM removal to be similar between eyes operated with and without Trypan blue.…”

Section: Discussionmentioning

confidence: 99%

“…Anatomical evaluation shows that there was no increase in apoptosis or other indicators of retinal toxicity when HTB was used. 5,32,33 The main disadvantage of Trypan blue, as formulated in MembraneBlue (DORC), is that an air-fluid exchange (AFX) is required to achieve adequate staining. The procedure itself increases the risk of surgical complications including retinal tears.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure itself increases the risk of surgical complications including retinal tears. 5,22 It also makes repeat applications of the dye less practical. To eliminate the need for an AFX, it is possible to either mix the dye with glucose to increase the osmolarity or to decrease the osmolarity by changing the infusion fluid (eg to Hartmann solution).…”

Section: Discussionmentioning

confidence: 99%

“…These have included the use of a slit beam illumination, triamcinolone, 1 and stains such as Indocyanine and infracyanine green (ICG), brilliant blue, 2,3 and Trypan blue. [4][5][6][7][8] Owing to a superior safety profile as compared with ICG, Trypan blue has been used by a number of European surgeons despite its lesser staining characteristics for the ILM. 7,9,10 The commercially available version of Trypan blue (MembraneBlue, DORC, Zuidland, The Netherlands) used in vitreoretinal surgery is diluted in phosphate-buffered saline.…”

Section: Introductionmentioning

confidence: 99%

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Use of heavy Trypan blue in macular hole surgery

Oberstein

Smet

2010

Eye

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Purpose Intraocular dyes facilitate the identification of the inner limiting membrane (ILM) during surgery. Appropriate dyes should be safe, provide adequate staining, and be easy to use. Heavy Trypan blue eliminates the need for an air-fluid exchange (AFX) and appears to have little retinal toxicity. This study refers to a prospective, consecutive trial with heavy Trypan blue in macular hole surgery. Patients and methods A consecutive group of 20 patients with full thickness macular holes was recruited in a single institution study. Patients were operated using conventional methods. Heavy Trypan blue was prepared by mixing isovolumetrically glucose 10% with MembraneBlue (DORC, Zuidland, The Netherlands). Patients were assessed for ease of surgery and post-operatively at 3 and 6 months (vision and ocular coherence tomography) for hole closure and vision. Results Twenty eyes were included in the study. Reapplication of dye was used in 75% of the cases, leading to improved contrast further facilitating the ILM peel. In no case was an AFX necessary to obtain sufficient staining. Macular hole closure was achieved in 19 of 20 patients with one surgery. No retinal detachment or other complication was observed in the follow-up period. Conclusion Heavy Trypan blue can be delivered efficiently to the retinal surface without the need for an AFX. Staining was sufficient to help visualise and peel the ILM. Repeat applications were easily performed. The macular hole closure rate was similar to that of other series with a comparable visual improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Use of heavy Trypan blue in macular hole surgery

Oberstein

Smet

2010

Eye

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show abstract

“…( In this case of post-traumatic cataract with subluxation, the dye was noted to enter the vitreous cavity through clinically evident and nonevident areas of zonular loss. Although Trypan blue at a concentration of 0.06% with exposure time of 2 min has not been found to cause retinal toxicity, [3][4][5] prolonged dye exposure has been reported to be toxic to the retina. In this case, the dye remained in the vitreous for 4 days thereby resulting in toxicity.…”

Section: Case Reportmentioning

confidence: 98%