Functional organ preservation in laryngeal and hypopharyngeal cancer

Ambrosch, Petra; Fazel, Asita

doi:10.3205/cto000075

Cited by 7 publications

(4 citation statements)

References 238 publications

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“…The 5-year overall survival rates for Tucker’s and Majer-Piquet’s techniques range between 82% and 95%, respectively. 7 , 12 , 15 , 16 The 3-year and 5-year overall survival rates at our study were 97.6% and 85.7%, respectively. Several studies have shown that lymph node metastasis or presence of unclear surgical margin decreases survival and that patients with no clear surgical margins need a close follow-up.…”

Section: Discussionmentioning

confidence: 46%

Subtotal Laryngectomy with Epiglottic Reconstruction for Glottic Carcinoma: A Single Institutional Experience

Minh¹,

Dinh²,

Hong³

et al. 2022

IJGM

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Aim Laryngeal cancer is a common form of head and neck cancer in Vietnam where the current treatment is surgery. Subtotal laryngectomy with epiglottic reconstruction, a conservative surgery, allows removal of anterior commissure including thyroid cartilage and paraglottic space and provides a maximum restoration of the anatomical structure of the larynx. Purpose To evaluate the results, the safety and effectiveness of patients who were treated with subtotal laryngectomy with epiglottic reconstruction. Material and Method From January 2012 to July 2017, 42 patients (41 male, 1 female, median age 55.6 years, range 38–75 years) were diagnosed with glottic carcinomas at Vietnam National ENT Hospital, where they underwent a subtotal laryngectomy with epiglottic reconstruction. Results Thirty-one patients (73.8%) had T2 glottic carcinoma, 4 (9.5%) T3 glottic carcinoma, and 12 (25.6%) had neck dissection. The arytenoid cartilage on the tumor-bearing side was resected in 11 patients (26.2%). Functional ipsilateral neck dissection was performed in 30 patients. Positive lymph node of stage T2 was 1/31 (3.2%). Postoperative histopathologic examination showed a tumour free of resection margin in 41 patients (97.6%). Only one post-operative complication occurred with bleeding 24 hours after surgery. There was no mortality. The 3- and 5-year overall survival rates were 97.6% and 85.7%, respectively. The rate of local control was 92.9%. Conclusion Subtotal laryngectomy with epiglottic reconstruction was performed mostly for T2 and certain T3 glottic carcinomas when there is difficult to safely remove the tumour with transoral laser microsurgery. This surgery appears to be effective for the overall survival and has potential in clinical practice for treating moderate glottic carcinoma.

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Section: Discussionmentioning

confidence: 46%

Subtotal Laryngectomy with Epiglottic Reconstruction for Glottic Carcinoma: A Single Institutional Experience

Minh¹,

Dinh²,

Hong³

et al. 2022

IJGM

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“…Treatment of hypopharyngeal cancer remains challenging and requires a multidisciplinary team to establish the optimal treatment options. The primary goal is to improve survival from an oncological perspective and provide functional organ preservation wherever feasible ( 13 ). Because there is a substantial proportion of patients with HNC with cigarette smoking, chewing betel nuts and drinking alcohol habits, which are common carcinogens for esophageal SCC, the risk of developing malignancies in the entire aerodigestive tract, including the lungs and esophagus, is high ( 8 – 10 , 14 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients

Chung,

Wu,

Lin

et al. 2024

Front. Oncol.

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IntroductionPatients with head and neck cancer may develop a second primary neoplasm (SPN) of the esophagus due to field cancerization. This study investigated the impacts of esophageal cancer screening using magnifying endoscopy with narrow-band imaging (ME-NBI) on the outcomes of hypopharyngeal cancer patients.MethodsPatients with hypopharyngeal cancer diagnosed from 2008 to 2021 in a tertiary hospital were reviewed retrospectively. Screening and surveillance using ME-NBI examination of the esophagus were divided into three patterns: (1) ME-NBI never performed or more than 6 months after diagnosis of index primary hypopharyngeal cancer, (2) ME-NBI within 6 months only, and (3) ME-NBI within 6 months and regular surveillance.ResultsA total of 261 were reviewed and 21 (8%) patients were in stage I, 20 (8%) in stage II, 27 (10%) in stage III, 116 (44%) in stage IVA, 65 (25%) in stage IVB, and 12 (5%) in stage IVC. Sixty-seven (26%) patients had SPN (50 esophagus, 10 oral cavity, 3 oropharynx, 2 nasopharynx, 1 larynx and 1 lung). Among esophageal SPN, 35 (70%) and 15 (30%) patients developed synchronous and metachronous neoplasia, respectively. In multivariate Cox regression analysis, advanced stages III and IV (compared with stages I and II, HR: 1.86, 1.18-2.95, p=0.008), ME-NBI examination of the esophagus received within 6 months and regular surveillance (HR: 0.53, 0.36-0.78, p=0.001) were independent factors affecting the overall survival of patients with hypopharyngeal cancer.DiscussionOur findings demonstrated that screening and surveillance of esophageal SPN by ME-NBI improves the survival of patients with hypopharyngeal cancer.

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“…Hoarseness can be due to the impaired function and structure of the cover-body system of the vocal cords, vocal fold movement problems associated with direct tumor spread to the paraglottic space or the thyroarytenoid joint, or infiltration of the recurrent laryngeal nerve [ 10 ]. Altered voice quality can also occur by structural abnormalities (i.e., presence of the tumor mass) in the pharynx and oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Patient delay and its clinical significance among head and neck cancer patients in Hungary

Dános,

Horváth,

Halász

et al. 2023

Pathol. Oncol. Res.

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Introduction: Head and neck cancers represent a major health problem in Hungary. With their high incidence and mortality rates, Hungary is one of the world leaders in these indicators. The length of patient delay, defined as time from onset of symptoms to first medical consultation, is unknown in Hungarian patients with head and neck cancer. We aimed to use a representative sample of the Hungarian head and neck cancer patient population to determine patient delay according to disease localization and stage and to identify correlations with other clinical parameters.Methods: In our retrospective study, we reviewed patient documentation. For the inclusion, the patients had to be diagnosed with malignant tumors of the oral cavity, oropharynx, hypopharynx or larynx at the Department Head and Neck Surgery of Semmelweis University between 2012 and 2017.Results: We identified 236 patients who met the inclusion criteria. The median delay was 9.5 weeks (range 0–209 weeks) and the mean delay of patients was 17.57 weeks (SD 23.67). There was a significant difference in patient delay data by location. Among glottic cancers, the most common diagnosis was an early stage (67%), compared with other localizations, including most commonly the oropharynx (81%) and hypopharynx (80%), where a locoregionally advanced stage was more frequent.Discussion: Compared to data from different countries, the delay of Hungarian patients with head and neck cancer is significantly longer, which may contribute to the high mortality in Hungary. Screening and patient education in high-risk groups could contribute to earlier diagnosis and thus improve prognosis.

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Functional organ preservation in laryngeal and hypopharyngeal cancer

Cited by 7 publications

References 238 publications

Subtotal Laryngectomy with Epiglottic Reconstruction for Glottic Carcinoma: A Single Institutional Experience

Subtotal Laryngectomy with Epiglottic Reconstruction for Glottic Carcinoma: A Single Institutional Experience

Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients

Patient delay and its clinical significance among head and neck cancer patients in Hungary

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