2000
DOI: 10.1523/jneurosci.20-13-05076.2000
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Functional Nicotinic Acetylcholine Receptors That Mediate Ganglionic Transmission in Cardiac Parasympathetic Neurons

Abstract: Nicotinic acetylcholine receptors (nAChRs) mediate ganglionic transmission in the peripheral autonomic nervous system in mammals. Functional neuronal nAChRs have been shown to assemble from a combination of alpha and beta subunits, including alpha3, alpha5, alpha7, beta2, and beta4 in RNA-injected oocytes, but the subunit composition of functional neuronal nAChRs in vivo in mammals remains unknown. We examined the subunit composition of functional nAChRs in the intracardiac parasympathetic ganglion in a physio… Show more

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Cited by 69 publications
(58 citation statements)
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“…The high degree of subunit specificity of G-protein modulation of neuronal nAChRs is intriguing, given that neuronal nAChRs of rat intrinsic cardiac ganglia have been shown to be composed mainly of ␣3, ␣5, ␣7, ␤2, and ␤4 subunits (Poth et al, 1997;Bibevski et al, 2000) and that a large component of cholinergic (vagal) transmission in intracardiac neurons is mediated by the ␣3␤2 subunit (Bibevski et al, 2000). G-protein activation did not modify currents evoked by the cholinergic agonist, cytisine, which has been shown to be most potent for ␣3␤4 and ␣3␤4␣5 subunit combinations (Covernton et al, 1994).…”
Section: Discussionmentioning
confidence: 99%
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“…The high degree of subunit specificity of G-protein modulation of neuronal nAChRs is intriguing, given that neuronal nAChRs of rat intrinsic cardiac ganglia have been shown to be composed mainly of ␣3, ␣5, ␣7, ␤2, and ␤4 subunits (Poth et al, 1997;Bibevski et al, 2000) and that a large component of cholinergic (vagal) transmission in intracardiac neurons is mediated by the ␣3␤2 subunit (Bibevski et al, 2000). G-protein activation did not modify currents evoked by the cholinergic agonist, cytisine, which has been shown to be most potent for ␣3␤4 and ␣3␤4␣5 subunit combinations (Covernton et al, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…The lack of G-protein binding and potentiation of ␣7 nAChRmediated currents by G-protein activation supports the hypothesis that at least one ␤ subunit of the nAChR is required for G-protein activation. The high probability of the occurrence of ␣3␤2-containing nAChRs in mammalian intracardiac neurons (Poth et al, 1997;Bibevski et al, 2000) explains the robust potentiation of ACh-and nicotine-evoked currents by G-protein subunits. The coimmunoprecipitation of native nAChRs with G o ␣ and G␤␥ subunits clearly demonstrates direct protein interaction.…”
Section: Discussionmentioning
confidence: 99%
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“…While in mice and rats ␤2* nAChRs seem to have a minor role in the autonomic control of cardiac function, in dogs ␣3␤2* nAChRs have been proposed as the main mediators of ganglionic transmission in intracardiac ganglia. In these animals, the contribution of ␣3␤4* receptors that do not contain ␤2 at the same time (i.e., ␣3␤4 vs. ␣3␤2␤4 combinations) is not clear (Bibevski et al, 2000).…”
Section: Nachrs In the Control Of Cardiac Functionmentioning
confidence: 96%
“…The ␣3 nAChR subunit is expressed at high levels in all autonomic ganglia, including the sympathetic ganglia innervating the heart and the cardiac ganglionated plexuses (Cimino et al, 1992;Mandelzys et al, 1994;Rust et al, 1994;Poth et al, 1997). ␣3 is likely to participate in the majority of nAChR subtypes expressed by autonomic neurons (Listerud et al, 1991;Poth et al, 1997;Xu et al, 1999a;Bibevski et al, 2000) because its absence produces a severe in vivo phenotype with high perinatal mortality and autonomic dysfunction at the level of several organ systems (Xu et al, 1999a;De Biasi et al, 2000). Acutely isolated superior cervical ganglion (SCG) neurons from ␣3 null (Ϫ/Ϫ) mice express only two out of the five nAChR currents recorded from wild-type (ϩ/ϩ) neurons.…”
Section: Nachrs In the Control Of Cardiac Functionmentioning
confidence: 99%