Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Krisnawati, Dyah Ika; Liu, Yung Ching; Lee, Yuarn Jang; Wang, Yun Ting; Chen, Chia Ling; Tseng, Po Chun; Lin, Chiou Feng

doi:10.1038/s41598-019-41952-1

Cited by 27 publications

(52 citation statements)

References 17 publications

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“…The patients with NTM infection more likely showed defect in signal transduction of IFN-γ/IL-12 axis, especially in patients with disseminated NTM diseases 14 . Besides, the patients with NTM infection commonly express high levels of anti-IFN-γ autoantibodies and suffer from recurrent infection 15,16 . www.nature.com/scientificreports www.nature.com/scientificreports/ NTM was more likely to infect older females as reported previously 1,17,18 ; this may suggest that estrogen has a protective role against NTM 18 .…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

Sun

et al. 2020

Sci Rep

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to achieve a comprehensive understanding of the characteristics of patients with non-tuberculous mycobacteria (NTM), patients with NTM between January 2016 and June 2019 were recruited from a primary hospital. NTM were identified based on the MBP64 protein assay. The clinical records and laboratory assay results were retrospectively reviewed. A total of 204 patients with NTM were included in the final analysis. The patients with multiple isolations were more likely accompanied with chronic obstructive pulmonary disease (copD) (p = 0.029) and arthritis (p = 0.049), but showed a lower percentage of positive t-spot results (p = 0.022). In addition, patients with multiple isolations showed a higher rate of positive acid-fast staining results and their symptom duration was more likely longer than 30 days (p = 0.019). Patients with a positive response in T-spot assay showed a higher proportion of nodular manifestation on computed tomography (ct) than those with a negative response. compared with male patients with ntM, female patients showed lower rates of positive acid-fast staining results (p = 0.03), but were more likely accompanied with COPD (p < 0.0001). The positive acid-fast staining results were closely associated with pulmonary cavities and tuberculosis antibody. patients with different NTM isolation frequencies were closely associated with coexisting diseases and examination results.

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Section: Discussionmentioning

confidence: 99%

Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

Sun

et al. 2020

Sci Rep

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“…An estimated 81% of patients with recurrent non-tuberculous mycobacterial infections have high levels of anti-IFNγ neutralizing antibodies, and decreased levels of serum IFNγ. Krisnawati et al demonstrated that these patients' serum blocked IFNγ activation of STAT1 and transactivation of IRF1 [36]. Some, but not all anti-IFNγ antibodies bound to a major epitope region (amino acid residues 121-131) required for IFN receptor activation.…”

Section: Deleterious Effects Of Acaasmentioning

confidence: 99%

Anti-Cytokine Autoantibodies in Systemic Lupus Erythematosus

Howe

Leung

2019

Cells

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Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Clustering patients by cytokine and disease activity subsets is more informative than isolated cytokine studies, as both pro inflammatory and immunoregulatory cytokines contribute to the cytokine dysregulated state in SLE. Endogenous anti-cytokine autoantibodies (ACAAs) may be involved in the regulation of cytokine biology by reducing excessive production or by prolonging their half-life in the circulation through the formation of cytokine-antibody immune complexes. Although endogenous ACAAs may have deleterious effects such as contributing to immunodeficiency states, their role in the pathophysiology of autoimmune conditions such as SLE has yet to be clearly elucidated. The aim of the present article is to provide a focused review of the current knowledge of ACAAs in SLE.

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“…Patients affected by "Adult-onset immunodeficiency with susceptibility to mycobacteria", belong to the category "Phenocopies of inborn errors of immunity", produce autoantibodies against IFN-γ and have increased susceptibility to NTM [84,[98][99][100][101][102][103][104][105][106][107][108].…”

Section: Immunodeficienciesmentioning

confidence: 99%

Pulmonary non-tuberculous mycobacterial infections: current state and future management

Chin

Sarmiento

Alvarez-Cabrera

et al. 2019

Eur J Clin Microbiol Infect Dis

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Currently, there is a trend of increasing incidence in pulmonary non-tuberculous mycobacterial infections (PNTM) together with a decrease in tuberculosis (TB) incidence, particularly in developed countries. The prevalence of PNTM in underdeveloped and developing countries remains unclear as there is still a lack of detection methods that could clearly diagnose PNTM applicable in these low-resource settings. Since non-tuberculous mycobacteria (NTM) are environmental pathogens, the vicinity favouring host-pathogen interactions is known as important predisposing factor for PNTM. The ongoing changes in world population, as well as socio-political and economic factors, are linked to the rise in the incidence of PNTM. Development is an important factor for the improvement of population well-being, but it has also been linked, in general, to detrimental environmental consequences, including the rise of emergent (usually neglected) infectious diseases, such as PNTM. The rise of neglected PNTM infections requires the expansion of the current efforts on the development of diagnostics, therapies and vaccines for mycobacterial diseases, which at present, are mainly focused on TB. This review discuss the current situation of PNTM and its predisposing factors, as well as the efforts and challenges for their control.

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Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Cited by 27 publications

References 17 publications

Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

Anti-Cytokine Autoantibodies in Systemic Lupus Erythematosus

Pulmonary non-tuberculous mycobacterial infections: current state and future management

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