Functional neurological disorders after <scp>COVID</scp>‐19 vaccination: Case series and literature review

Takahashi, Osamu; Sakakibara, Ryuji; Sawai, Setsu; Ogata, Tsuyoshi

doi:10.1111/pcn.13453

Cited by 4 publications

(4 citation statements)

References 10 publications

(31 reference statements)

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“…FND after vaccination has been reported with other vaccines, and COVID-19 vaccine-related FND has aroused great interest from clinicians due to it being widespread [ 145 ]. COVID-19 vaccine-related FND accounts for 2.88 to 3.5% of COVID-19 vaccine-related neurological complications [ 40 , 146 ]. Some patients with existing FND reported worsening symptoms, while new-onset cases are rapidly increasing.…”

Section: Discussionmentioning

confidence: 99%

“…FND occurs after almost every type of COVID-19 vaccine [ 147 ]. There are diverse clinical manifestations, including motor, sensory, visual, and hypersensitivity [ 146 ]. The onset time varies from several minutes to weeks, but most cases attack suddenly with a mean onset time of 1 day [ 146 , 147 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are diverse clinical manifestations, including motor, sensory, visual, and hypersensitivity [ 146 ]. The onset time varies from several minutes to weeks, but most cases attack suddenly with a mean onset time of 1 day [ 146 , 147 ]. Even with the intervention of psychologists, some patients remain with disabilities [ 148 ].…”

Section: Discussionmentioning

confidence: 99%

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Neurological Disorders following COVID-19 Vaccination

Yang

Huang

2023

Vaccines

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Nowadays, people all over the world have been receiving different types of coronavirus disease 2019 (COVID-19) vaccines. While their effectiveness has been well recognized, various post-vaccination disorders are not fully understood. In this review, we discuss neurological disorders related to vascular, immune, infectious, and functional factors following COVID-19 vaccination, and attempt to provide neuroscientists, psychiatrists, and vaccination staff with a reference for the diagnosis and treatment of these diseases. These disorders may present as a recurrence of previous neurological disorders or new-onset diseases. Their incidence rate, host and vaccine characteristics, clinical manifestations, treatment, and prognosis differ significantly. The pathogenesis of many of them remains unclear, and further studies are needed to provide more evidence. The incidence rate of severe neurological disorders is relatively low, most of which are reversible or treatable. Therefore, the benefits of vaccination outweigh the risk of COVID-19 infection, especially among fragile populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neurological Disorders following COVID-19 Vaccination

Yang

Huang

2023

Vaccines

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“…Fluctuating limb dysesthesia or sensory impairment with inconsistent midline boundaries on examination with exact splitting of sensation in the boundaries of specific dermatome or nerve territory observed in patient #1 are suggestive of FND. Numbness in the four extremities associated with pain or weakness resembling polyneuropathies, commonly beginning within 24 h of Covid-19 vaccine administration, were the most frequent phenotype of FND in a retrospective study in Japan [ 19 ]. Although uncommon, post-vaccination Guillain-Barré syndrome was reported as a major neurological complication of Covid-19 vaccine which generally appeared within 2 weeks of vaccine administration, as a result of molecular mimicry [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic challenges of functional neurological disorders after covid-19 disease or vaccination: case series and review of the literature

2022

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Background Functional neurological disorders have rarely been described in patients recovering from Covid-19 or after vaccination but they are probably under diagnosed. Material and methods Six patients referred for rehabilitation of persistent symptoms and/or sequelae of Coronavirus disease 2019 (COVID-19) were diagnosed with functional neurological disorders. A literature review was conducted to identify reported cases of functional neurological disorders after Covid-19 infection or vaccination. Results In the current case series, patients diagnosed with functional neurological disorders presented high variability of clinical symptoms including hemiplegia, lower limb unilateral or bilateral paralysis, myoclonus, dystonia, tremor and sensory impairment. Four patients were young females with mild Covid-19 infection without hospital admission. Their neurological symptoms developed over the course of 4 weeks after the beginning of Covid-19 symptoms or vaccine administration with normal ancillary exams. One patient presented overlapping functional neurological symptoms and mild impairment of the left common peroneal nerve after prolonged ICU stay. In addition, all patients in our case series reported other non-motor symptoms such as fatigue, cognitive impairment and diffuse pain or dysesthesia, which are compatible with post Covid-19 condition. Conclusions It is important that clinicians recognize functional neurological symptoms and consider it as a differential diagnosis in patients with neurological complications of Covid-19 infection and vaccination. Supplementary Information The online version contains supplementary material available at 10.1007/s13760-022-02140-7.

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Neurological Complications Following COVID-19 Vaccination

Chatterjee

Chakravarty

2022

Curr Neurol Neurosci Rep

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Purpose of Review A variety of neurological complications have been reported following the widespread use of the COVID-19 vaccines which may lead to vaccine hesitancy and serve as a major barrier to the public health aim of achieving protective herd immunity by vaccination. In this article, we review the available evidence regarding these neurological adverse events reported, to provide clarity regarding the same so that unfounded fears maybe put to rest. Recent Findings There is a greater than expected occurrence of severe neurological adverse events such as cortical sinus venous thrombosis, Bell’s palsy, transverse myelitis, and Guillain–Barré syndromes along with other common effects such as headaches following different kinds of COVID-19 vaccination. Precipitation of new onset demyelinating brain lesions with or without detection of specific antibodies and worsening of pre-existing neurological disorders (like epilepsy, multiple sclerosis) are also a matter of great concern though no conclusive evidence implicating the vaccines is available as of now. Summary The COVID-19 pandemic is far from being over. Till such time that a truly effective anti-viral drug is discovered, or an appropriate therapeutic strategy is developed, COVID-appropriate behavior and highly effective mass vaccination remain the only weapons in our armamentarium to fight this deadly disease. As often occurs with most therapeutic means for the treatment and prevention of any disease, vaccination against COVID-19 has its hazards. These range from the most trivial ones like fever, local pain and myalgias to several potentially serious cardiac and neurological complications. The latter group includes conditions like cerebral venous thrombosis (curiously often with thrombocytopenia), transverse myelitis and acute inflammatory demyelinating polyneuropathy amongst others. Fortunately, the number of reported patients with any of these serious complications is far too low for the total number of people vaccinated. Hence, the current evidence suggests that the benefits of vaccination far outweigh the risk of these events in majority of the patients. As of now, available evidence also does not recommend withholding vaccination in patients with pre-existing neurological disorders like epilepsy and MS, though adenoviral vaccines should be avoided in those with history of thrombotic events.

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Functional neurological disorders after COVID‐19 vaccination: Case series and literature review

Cited by 4 publications

References 10 publications

Neurological Disorders following COVID-19 Vaccination

Neurological Disorders following COVID-19 Vaccination

Diagnostic challenges of functional neurological disorders after covid-19 disease or vaccination: case series and review of the literature

Neurological Complications Following COVID-19 Vaccination

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