Functional neuroimaging studies in addiction: Multisensory drug stimuli and neural cue reactivity

Yalachkov, Yavor; Kaiser, Jochen; Naumer, Marcus J.

doi:10.1016/j.neubiorev.2011.12.004

Cited by 104 publications

(92 citation statements)

References 78 publications

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“…Importantly, under changing situations, the meaning or value Multisensory cues, incentive value, and dopamine www.learnmem.org of CS may be altered, modifying patterns of neurotransmission, and ensuring behavioral flexibility. The use of complex stimuli, such as the lever, in animal models of conditioning is important given that in humans the sensory modality of cues influences their ability to alter brain activation (Yalachkov et al 2012) and subsequently motivate food-and drug-seeking behavior (Johnson et al 1998;Shadel et al 2001;Reid et al 2006). …”

Section: Discussionmentioning

confidence: 99%

The sensory features of a food cue influence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens core

et al. 2016

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The sensory properties of a reward-paired cue (a conditioned stimulus; CS) may impact the motivational value attributed to the cue, and in turn influence the form of the conditioned response (CR) that develops. A cue with multiple sensory qualities, such as a moving lever-CS, may activate numerous neural pathways that process auditory and visual information, resulting in CRs that vary both within and between individuals. For example, CRs include approach to the lever-CS itself (rats that "sign-track"; ST), approach to the location of reward delivery (rats that "goal-track"; GT), or an "intermediate" combination of these behaviors. We found that the multimodal sensory features of the lever-CS were important to the development and expression of sign-tracking. When the lever-CS was covered, and thus could only be heard moving, STs not only continued to approach the lever location but also started to approach the food cup during the CS period. While still predictive of reward, the auditory component of the lever-CS was a much weaker conditioned reinforcer than the visible lever-CS. This plasticity in behavioral responding observed in STs closely resembled behaviors normally seen in rats classified as "intermediates." Furthermore, the ability of both the lever-CS and the reward-delivery to evoke dopamine release in the nucleus accumbens was also altered by covering the lever-dopamine signaling in STs resembled neurotransmission observed in rats that normally only GT. These data suggest that while the visible lever-CS was attractive, wanted, and had incentive value for STs, when presented in isolation, the auditory component of the cue was simply predictive of reward, lacking incentive salience. Therefore, the specific sensory features of cues may differentially contribute to responding and ensure behavioral flexibility.

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Section: Discussionmentioning

confidence: 99%

The sensory features of a food cue influence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens core

et al. 2016

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“…The insula is a large and heterogeneous region with multiple functions, including a general role in interoception, with the posterior insula particularly involved in integrating sensory inputs (Craig, 2009). In addition, it has been suggested that it is directly involved in response to drug cues (Childress et al, 2008;Yalachkov et al, 2012), drug craving (Garavan, 2010), and gambling urges (Goudriaan et al, 2010). Further, damage to this region has been linked to rapid smoking cessation and the elimination of cigarette craving (Naqvi et al, 2007) and abolishes cognitive distortions that drive gambling behavior (eg, 'gambler's fallacy'; Clark et al, 2014).…”

Section: Cocaine Cravings and Gambling Urges H Kober Et Almentioning

confidence: 99%

Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study

Kober

Lacadie

Wexler

et al. 2015

Neuropsychopharmacol

147

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Although craving states are important to both cocaine dependence (CD) and pathological gambling (PG), few studies have directly investigated neurobiological similarities and differences in craving between these disorders. We used functional magnetic resonance imaging (fMRI) to assess brain activity in 103 participants (30 CD, 28 PG, and 45 controls) while they watched videos depicting cocaine, gambling, and sad scenarios to investigate the neural correlates of craving. We observed a three-way urge type × video type × diagnostic group interaction in self-reported craving, with CD participants reporting strong cocaine cravings to cocaine videos, and PG participants reporting strong gambling urges to gambling videos. Neuroimaging data revealed a diagnostic group × video interaction in anterior cingulate cortex/ventromedial prefrontal cortex (mPFC), activating predominantly to cocaine videos in CD participants, and a more dorsal mPFC region that was most strongly activated for cocaine videos in CD participants, gambling videos in PG participants, and sad videos in control participants. Gender × diagnosis × video interactions identified dorsal mPFC and a region in posterior insula/caudate in which female but not male PG participants showed increased responses to gambling videos. Findings illustrate both similarities and differences in the neural correlates of drug cravings and gambling urges in CD and PG. Future studies should investigate diagnostic-and gender-specific therapies targeting the neural systems implicated in craving/urge states in addictions.

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“…Subsequent exposure to these same drug-associated environments and stimuli appear to elicit conditioned neuropsychophysiological responses that increase likelihood of relapse through association with drug-related reward (Robinson & Berridge, 2008). Consistent with this view, functional brain imaging studies have identified brain regions, including areas such as the ventral striatum (VS) and amygdala, which are reliably activated when substance-abusing individuals are presented with drugassociated cues (Kühn & Gallinat, 2011;Yalachkov, Kaiser, Advance Access publication March 22, 2014 nicotine & tobacco research, volume 16, number 7 (July 2014) 939-947 & Naumer, 2012). The results of these neuroimaging studies may be clinically relevant as they provide insight into the cue-associated neurobiological mechanisms that contribute to drug relapse.…”

Section: Introductionmentioning

confidence: 90%

“…Brain systems that are identified in such studies may become useful biomarkers of addiction severity and vulnerability to relapse and may be targeted for tailored treatment strategies (Sweet, 2011;Sweet, MacKillop, & Amlung, 2013;Yalachkov et al, 2012). Given the higher propensity for cue reactivity and smoking cessation relapse in DRD4 VNTR L carriers, we sought to examine whether or not this high-risk genotype would be related to differential BOLD-fMRI response to smoking cues in the context of nicotine deprivation and replacement.…”

Section: Introductionmentioning

confidence: 99%

Effects of Nicotine Deprivation and Replacement on BOLD-fMRI Response to Smoking Cues as a Function of DRD4 VNTR Genotype

Xu¹,

Clark²,

David³

et al. 2014

Nicotine &Amp; Tobacco Research

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Functional neuroimaging studies in addiction: Multisensory drug stimuli and neural cue reactivity

Cited by 104 publications

References 78 publications

The sensory features of a food cue influence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens core

The sensory features of a food cue influence its ability to act as an incentive stimulus and evoke dopamine release in the nucleus accumbens core

Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study

Effects of Nicotine Deprivation and Replacement on BOLD-fMRI Response to Smoking Cues as a Function of DRD4 VNTR Genotype

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