Functional neuroimaging of mentalizing during the trust game in social anxiety disorder

Sripada, Chandra; Angstadt, Mike; Banks, Sarah; Nathan, Pradeep J.; Liberzon, Israel; Phan, K. Luan

doi:10.1097/wnr.0b013e32832d0a67

Cited by 106 publications

(73 citation statements)

References 25 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent work indicates that these biased cognitions may derive from an inability to infer how a social partner will view one’s social actions. To examine this possibility, Sripada and colleagues (71) used a trust game to compare neural responses when individuals were considering the actions of a real social partner or the actions of a computer partner. Individuals with social anxiety disorder showed diminished activity for social relative to nonsocial partners in a region of medial PFC implicated in theory-of-mind (72).…”

Section: Multiplayer Economic Games Quantify the Behavioral Dynamics mentioning

confidence: 99%

Understanding Interpersonal Function in Psychiatric Illness Through Multiplayer Economic Games

King‐Casas

Chiu

2012

Biological Psychiatry

View full text Add to dashboard Cite

Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships; these include autism, social phobia, and the personality disorders. Other psychopathologies confer significant difficulties in the social domain, including major depression, posttraumatic stress disorder, and psychotic disorders. Still other mental health conditions, including substance abuse and eating disorders, seem to be exacerbated or triggered in part by the influence of social peers. For each of these and other psychiatric conditions, the extent and quality of social support is a strong determinant of outcome such that high social support predicts symptom improvement and remission. Despite the central role of interpersonal factors in psychiatric illness, the neurobiology of social impairments remains largely unexplored, in part due to difficulties eliciting and quantifying interpersonal processes in a parametric manner. Recent advances in functional neuroimaging, combined with multiplayer exchange games drawn from behavioral economics, and computational/quantitative approaches more generally, provide a fitting paradigm within which to study interpersonal function and dysfunction in psychiatric conditions. In this review, we outline the importance of interpersonal factors in psychiatric illness and discuss ways in which neuroeconomics provides a tractable framework within which to examine the neurobiology of social dysfunction.

show abstract

Section: Multiplayer Economic Games Quantify the Behavioral Dynamics mentioning

confidence: 99%

Understanding Interpersonal Function in Psychiatric Illness Through Multiplayer Economic Games

King‐Casas

Chiu

2012

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…22,23 It is important to note, however, that while self-reported anxiety and sensitivity to negative stimuli are robustly observed, several studies reported no group differences in insula and amygdala reactivity. [24][25][26] This suggests that hyperactivation of emotion processing areas in patients with SAD depends on experimental details, such as stimulus type and modality 25 or task complexity. 26 In addition, increased activation during the processing of emotional faces has also been observed in other brain regions, such as the lateral and medial temporal and parietal cortices.…”

Section: Neural Correlates Of Aberrant Emotion Processing In Individumentioning

confidence: 99%

“…[24][25][26] This suggests that hyperactivation of emotion processing areas in patients with SAD depends on experimental details, such as stimulus type and modality 25 or task complexity. 26 In addition, increased activation during the processing of emotional faces has also been observed in other brain regions, such as the lateral and medial temporal and parietal cortices. 27,28 Few fMRI experiments have explicitly studied emotion regulation using pictorial stimuli in patients with SAD: Brühl and colleagues 29 instructed individuals with SAD to use the therapeutic emotion regulation strategy of "reality checking," during which the participant tries to evaluate the "complete reality" like an outside observer.…”

Section: Neural Correlates Of Aberrant Emotion Processing In Individumentioning

confidence: 99%

Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder

Gaebler

Daniels

Lamke

et al. 2014

J Psychiatry Neurosci

View full text Add to dashboard Cite

IntroductionEmotions are proposed to involve a "person-situation interaction that engages attention, has meaning to an individual, and causes a coordinated yet malleable multisystem response to the interaction," 1 including a subjectively experienced feeling component.2 Emotion regulation refers to processes that alter the nature, magnitude and duration of these multisystem responses and feelings.3 Once placed in an emotion-evoking situation, an individual can deploy attentional mechanisms for emotion regulation (e.g., through distraction or concentration) or use "cognitive reappraisal," whereby he or she modifies the situation's emotional importance by reinterpreting the outcomes and actions of the situation itself (situation-focused reappraisal) or by altering the situation's personal relevance (self-focused reappraisal).Emotion regulation by self-focused reappraisal has proven effective in decreasing negative emotional experience 4 and alter ing physiologic responses in both the central 3,5 and the auto nomic nervous system. Background: In healthy individuals, voluntary modification of self-relevance has proven effective in regulating subjective emotional experience as well as physiologic responses evoked by emotive stimuli. As social anxiety disorder (SAD) is characterized by both altered emotional and self-related processing, we tested if emotion regulation through self-focused reappraisal is effective in individuals with SAD. Methods: While undergoing 3 T functional magnetic resonance imaging, individuals with SAD and matched healthy controls either passively viewed neutral and aversive pictures or actively increased or decreased their negative emotional experience through the modification of selfrelevance or personal distance to aversive pictures. Participants rated all pictures with regard to the intensity of elicited emotions and selfrelatedness. Results: We included 21 individuals with SAD and 23 controls in our study. Individuals with SAD reported significantly stronger emotional intensity across conditions and showed a nonsignificant tendency to judge pictures as more self-related than controls. Compared with controls, individuals with SAD showed an overactivation in bilateral temporoparietal regions and in the posterior midcingulate cortex during the passive viewing of aversive compared with neutral pictures. During instructed emotion regulation, activation patterns normalized and no significant group differences were detected. Limitations: As no positive pictures were presented, results might be limited to the regu lation of negative emotion. Conclusion: During passive viewing of aversive images, individuals with SAD showed evidence of neural hyperreactivity that may be interpreted as increased bodily self-consciousness and heightened perspective-taking. During voluntary increase and decrease of negative emotional intensity, group differences disappeared, suggesting self-focused reappraisal as a successful emotion regulation strategy for individuals with SAD.

show abstract

“…Sripada et al (2009) showed that patients with clinically significant social anxiety exhibited less activation of parts of this network during mentalizing compared with the results of matched healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Perception of other people’s mental states affects humor in social anxiety

Samson

Lackner

Weiss

et al. 2012

Journal of Behavior Therapy and Experimental Psychiatry

View full text Add to dashboard Cite

a b s t r a c tBackground and objectives: The present study examined the relationship between social anxiety and the appreciation of specific types of humor. It was expected that social anxiety would hinder the enjoyment of jokes particularly if the resolution of incongruity involves processing social cues and assessing the (false) mental states of others. Fifty-six participants rated three types of cartoons and a control condition for comprehensibility and funniness. Results: High degrees of social anxiety were associated with less enjoyment of cartoons that involved the interpretation of others' mental states (Theory of Mind), but not of semantic cartoons or visual puns. Furthermore, high social anxiety was related to longer response latencies of the funniness ratings, especially in the case of Theory of Mind cartoons. Limitations: A possible limitation is that the present study was conducted in individuals with social anxiety in the non-clinical range. Conclusions: The findings suggest that highly socially anxious people do not have a general humor processing deficit, but may feel threatened by tasks involving the mental states of others. The negative affect evoked by TOM humor may hinder the experience of funniness in highly socially anxious individuals, and it may also make it more difficult for them to rate their own amusement.

show abstract

Functional neuroimaging of mentalizing during the trust game in social anxiety disorder

Cited by 106 publications

References 25 publications

Understanding Interpersonal Function in Psychiatric Illness Through Multiplayer Economic Games

Understanding Interpersonal Function in Psychiatric Illness Through Multiplayer Economic Games

Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder

Perception of other people’s mental states affects humor in social anxiety

Contact Info

Product

Resources

About