Functional Neuroimaging in Parkinson's Disease

Niethammer, Martin; Feigin, Andrew; Eidelberg, David

doi:10.1101/cshperspect.a009274

Cited by 64 publications

(36 citation statements)

References 199 publications

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“…PET and SPECT are molecular imaging methods that employ exogenous, radiolabeled agents (Hammoud et al, 2007; Niethammer et al, 2012; Price, 2012). In general, PET methods have better spatial resolution and sensitivity than SPECT.…”

Section: Neuroimaging Methodsmentioning

confidence: 99%

Neuroimaging of Parkinson's disease: Expanding views

Weingarten

Sundman

Hickey

et al. 2015

Neuroscience & Biobehavioral Reviews

137

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Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson’s disease (PD). This review article begins with an introduction to PD neurobiology as a foundation for interpreting neuroimaging findings that may further lead to more integrated and comprehensive understanding of PD. Diverse areas of PD neuroimaging are then reviewed and summarized, including positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy and imaging, transcranial sonography, magnetoencephalography, and multimodal imaging, with focus on human studies published over the last five years. These included studies on differential diagnosis, co-morbidity, genetic and prodromal PD, and treatments from L-DOPA to brain stimulation approaches, transplantation and gene therapies. Overall, neuroimaging has shown that PD is a neurodegenerative disorder involving many neurotransmitters, brain regions, structural and functional connections, and neurocognitive systems. A broad neurobiological understanding of PD will be essential for translational efforts to develop better treatments and preventive strategies. Many questions remain and we conclude with some suggestions for future directions of neuroimaging of PD.

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Section: Neuroimaging Methodsmentioning

confidence: 99%

Neuroimaging of Parkinson's disease: Expanding views

Weingarten

Sundman

Hickey

et al. 2015

Neuroscience & Biobehavioral Reviews

137

View full text Add to dashboard Cite

show abstract

“…In this regard, dopamine transporter (DAT) imaging with single-photon emission CT (DAT-SPECT) is a very useful approach, because it is sensitive for the detection of presynaptic dopaminergic neuron degeneration in the striatum (Kägi et al 2010a). None of these methods is able to distinguish PD from other causes of degenerative parkinsonism, but presynaptic dopamine imaging is normal in essential tremor, dystonic tremor, drug-induced, psychogenic tremor, and psychogenic parkinsonism (for more on details on functional imaging in PD please refer to the text by Niethammer et al 2012). In appropriate circumstances, genetic testing might be considered; whenever a pathogenic mutation is found, a definitive diagnosis of PD is achieved in vivo.…”

Section: Diagnosis Of Pd and Differential Diagnosis How To Diagnose Pdmentioning

confidence: 99%

Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management

Massano

Bhatia

2012

Cold Spring Harbor Perspectives in Medicine

328

222

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“…In discussing this finding within the context of previous studies showing ventral thalamic activation during STN-DBS, the authors raise the possibility that activation of the neighboring STN may be the true source of some reported increases in thalamic blood flow and glucose metabolism. Interestingly, unmedicated Parkinson's patients at rest show hypermetabolism in the thalamus, part of the so-called Parkinson's Disease-Related Spatial Covariance Pattern (PDRP), which also includes GPi and primary motor cortex hyperactivity, as well as hypoactivity within supplementary motor cortices (Ma et al, 2007;Niethammer et al, 2012). In the context of the PDRP, the ventral thalamic inactivation reported by Geday et al may represent a normalization of pathological hyperactivity within the thalamocortical motor circuit.…”

Section: Circuit Modulations During Deep Brain Stimulation At the Stnmentioning

confidence: 99%

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

Albaugh

Shih²

2013

Brain Connectivity

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Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) represents a powerful clinical tool for the alleviation of many motor symptoms that are associated with Parkinson's disease. Despite its extensive use, the underlying therapeutic mechanisms of STN-DBS remain poorly understood. In the present review, we integrate and discuss recent literature examining the network effects of STN-DBS for Parkinson's disease, placing emphasis on neuroimaging findings, including functional magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography. These techniques enable the noninvasive detection of brain regions that are modulated by DBS on a whole-brain scale, representing a key experimental strength given the diffuse and far-reaching effects of electrical field stimulation. By examining these data in the context of multiple hypotheses of DBS action, generally developed through clinical and physiological observations, we define a multitude of consistencies and inconsistencies in the developing literature of this rapidly moving field.

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Functional Neuroimaging in Parkinson's Disease

Cited by 64 publications

References 199 publications

Neuroimaging of Parkinson's disease: Expanding views

Neuroimaging of Parkinson's disease: Expanding views

Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

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