Functional neuroanatomy of craving in heroin use disorder: voxel-based meta-analysis of functional magnetic resonance imaging (fMRI) drug cue reactivity studies

Pollard, Anna A; Hauson, Alexander O; Lackey, Nicholas S; Zhang, Emily; Khayat, Sarah; Carson, Bryce; Fortea, Lydia; Raduà, Joaquim; Grant, Igor

doi:10.1080/00952990.2023.2172423

Cited by 4 publications

(3 citation statements)

References 73 publications

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“…For example, Yang et al (2009) conducted a study examining neural responses to cue-reactivity in people who use heroin, reporting activation in the amygdala and cerebellum. Studies have also implicated increased recruitment of frontal regions and reward circuity, albeit with some variation in the specific peak locations when compared with our findings (Yang et al, 2009; Pollard et al, 2023). However, support for this result is variable, with other studies finding decreased activation in the left precentral gyrus (Moeller et al, 2010).…”

Section: Discussionsupporting

confidence: 61%

“…Taken together, studies have begun to identify common neural circuits implicated in cocaine and heroin use (Cooper et al, 2017; Hassani-Abharian et al, 2015; Jasinska et al, 2015; Pollard et al, 2023; Wang et al, 2015). Convergent cortical activation can be seen in various subregions within the prefrontal cortex including the dorsolateral, medial, and ventromedial regions as well within the cingulate cortex (Duncan et al, 2007; Elton et al, 2015; Goldstein et al, 2015; Hassani-Abharian et al, 2015; Hanlon et al, 2018; Kaag et al, 2018; Li et al, 2013; Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…For example, evidence suggests that cocaine use appears to recruit more tightly constrained circuits including canonical reward circuitry and the default mode network (Goldstein et al, 2009; Elton et al, 2015; Kaag et al, 2018) whereas activation associated with heroin use appears to be more widespread and more likely to include regions supporting motor function (Hassani-Abharian et al, 2015; Li et al, 2012; Li et al, 2013). Further, prior meta-analyses studying users of these substances have largely utilized broad inclusion criteria, examined users of a single drug (rather than a direct comparison across substances) or examined outcomes other than functional activation (e.g., gray matter, structural differences); these differences in methodology impact the ability to isolate activation patterns solely in response to reactivity to drug cues to neutral cues between users of these difference substances (Hall et al, 2015, Wollman et al, 2015; Wollman et al, 2017; Devoto et al, 2020; Suchting et al, 2020; Dang et al, 2022; Pollard et al, 2023). Thus, in order to completely understand differential activation patterns across these two substance s a more stringent synthesis regarding the neural circuits implicated in cocaine and heroin usage is needed.…”

Section: Introductionmentioning

confidence: 99%

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Common and Distinct Drug Cue Reactivity Patterns Associated with Cocaine and Heroin: An fMRI Meta-Analysis

Dejoie,

Senia,

Konova

et al. 2023

Preprint

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Substance use and substance use disorders (SUDs) represent ongoing major public health crises. Specifically, the use of illicit substances such as cocaine and heroin are responsible for over 50,000 drug related deaths annually. Our study used a comparative meta-analysis procedure to contrast activation patterns that may help explain the behavioral differences observed. PubMed and Google Scholar were searched for studies with within-subject whole brain analyses comparing drug to neutral cues for users of cocaine and heroin. A total of 18 studies were included, 9 in each subgroup. Voxel-based meta-analyses were performed using seed-based d mapping with permuted subject images (SDM-PSI) for subgroup mean analyses and a contrast meta-regression comparing the two substances. Mean analysis results indicated that users of heroin showed more widespread activation in the nucleus accumbens, right inferior and left middle temporal gyrus, the right thalamus, and the right cerebellum while cocaine use was associated with recruitment of lateral prefrontal cortex. Direct comparison of cue reactivity studies in heroin relative to cocaine users revealed greater activation in dopaminergic targets for users of heroin compared to users of cocaine. Differential activation patterns between substances may underlie behavioral differences observed across users of illicit substances, including seeking mood numbing effects in users of heroin. More consistent research methodology is needed to provide adequate studies for stringent meta-analyses examining common and distinct neural activation patterns across substances.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Common and Distinct Drug Cue Reactivity Patterns Associated with Cocaine and Heroin: An fMRI Meta-Analysis

Dejoie,

Senia,

Konova

et al. 2023

Preprint

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The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research

Li,

Kass,

Wiers

et al. 2024

Curr Addict Rep

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Purpose of Review The brain’s salience network (SN), primarily comprising the anterior insula and anterior cingulate cortex, plays a key role in detecting salient stimuli and processing physical and socioemotional pain (e.g., social rejection). Mounting evidence underscores an altered SN in the etiology and maintenance of substance use disorders (SUDs). This paper aims to synthesize recent functional neuroimaging research emphasizing the SN’s involvement in SUDs and physical/socioemotional pain and explore the therapeutic prospects of targeting the SN for SUD treatment. Recent Findings The SN is repeatedly activated during the experience of both physical and socioemotional pain. Altered activation within the SN is associated with both SUDs and chronic pain conditions, characterized by aberrant activity and connectivity patterns as well as structural changes. Among individuals with SUDs, functional and structural alterations in the SN have been linked to abnormal salience attribution (e.g., heightened responsiveness to drug-related cues), impaired cognitive control (e.g., impulsivity), and compromised decision-making processes. The high prevalence of physical and socioemotional pain in the SUD population may further exacerbate SN alterations, thus contributing to hindered recovery progress and treatment failure. Interventions targeting the restoration of SN functioning, such as real-time functional MRI feedback, neuromodulation, and psychotherapeutic approaches, hold promise as innovative SUD treatments. Summary The review highlights the significance of alterations in the structure and function of the SN as potential mechanisms underlying the co-occurrence of SUDs and physical/socioemotional pain. Future work that integrates neuroimaging with other research methodologies will provide novel insights into the mechanistic role of the SN in SUDs and inform the development of next-generation treatment modalities.

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Endogenous opiates and behavior: 2023

Bodnar

2024

Peptides

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Functional neuroanatomy of craving in heroin use disorder: voxel-based meta-analysis of functional magnetic resonance imaging (fMRI) drug cue reactivity studies

Cited by 4 publications

References 73 publications

Common and Distinct Drug Cue Reactivity Patterns Associated with Cocaine and Heroin: An fMRI Meta-Analysis

Common and Distinct Drug Cue Reactivity Patterns Associated with Cocaine and Heroin: An fMRI Meta-Analysis

The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research

Endogenous opiates and behavior: 2023

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