Functional Neural Predictors of Addiction Outcomes

Berkman, Elliot T.

doi:10.1002/9781118472415.ch21

Cited by 1 publication

(1 citation statement)

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“…Diminished neural activity to reward cues related to ELS might reflect one side of the asymmetry often found in addiction, characterized by decreased reactivity to non-drug cues and increased reactivity to drug cues ( Berkman, 2015 ). This is especially likely because the stimuli used in the studies reviewed above are normatively rewarding (e.g., money) but are often not personalized to the substance use patterns of the individual participant.…”

Section: Neuroimaging Evidence Documenting Neurodevelopmental Differementioning

confidence: 99%

Leveraging translational neuroscience to inform early intervention and addiction prevention for children exposed to early life stress

Roos

Horn

Berkman

et al. 2018

Neurobiology of Stress

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Substance use and addiction are disproportionately experienced by individuals with a history of exposure to early life stress (ELS), such as maltreatment, domestic violence and parent psychopathology. Unfortunately, extant interventions have mixed effectiveness at improving outcome trajectories for ELS-exposed children, who are often underserved by evidenced-based programs. Here, we employ a translational neuroscience framework to delineate how neuroscience can deepen our understanding of ELS-linked alterations in children's function to inform the development of more targeted, effective early intervention and addiction prevention programs. Candidate neural pathways altered by ELS and linked to addiction are described across sensory, affective, motivational, and executive function domains. Next, we provide an example of the application of translational neuroscience principles in a family of early interventions (i.e. Multidimensional Treatment Foster Care – Preschool, Kids in Transition to School) focused on improving self-regulation in ELS-exposed children. Future directions and areas of unmet need in intervention research detail the significant potential of translational neuroscience to advance interventionists' ability to support positive adjustment in ELS-exposed children and prevent harmful addiction outcomes.

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Section: Neuroimaging Evidence Documenting Neurodevelopmental Differementioning

confidence: 99%