Functional near-infrared spectroscopy reveals brain activity on the move

Sakai, Jill

doi:10.1073/pnas.2208729119

Cited by 17 publications

(10 citation statements)

References 12 publications

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“…For those reasons, using an EEG device, whether conventional or mobile, is challenging for this study focusing on complex cognitive activity when school children and students solve for a number of minutes in an erratic, unpredictable manner (Xu and Zhong, 2018). Finally, fNIRS signals can show long-lasting changes to examine what happens during mathematical word problem solving (Sakai, 2022). Compared to fMRI, fNIRS has a lower spatial resolution and cannot detect blood flow activity in deeper brain regions (over 1-2 cm).…”

Section: Purpose and Rationale Of The Present Studymentioning

confidence: 99%

Brain imaging provides insights about the interaction between instruction and diagram use for mathematical word problem solving

et al. 2022

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Diagram use is generally considered an effective strategy in solving mathematical word problems, and many teachers demonstrate the use of this strategy when they are teaching. Despite such demonstrations, however, the majority of students evidence poor, ineffective use of diagrams in problem solving. This may be due to a lack of task-appropriate instruction, but to date, there is inadequate evidence to support this idea. Therefore, the present study aimed to better understand the development of diagram use competence following the provision of task-appropriate instruction, focusing on both behavioral and neurophysiological evidence (i.e., brain activity, using functional near-infrared spectroscopy or fNIRS). Sixteen participants (mean age 15.7 years) were asked to solve mathematical word problems for which the use of tables (which is one kind of diagram) was deemed effective. Data collection progressed in three phases: (1) Pre-test without the demand for diagram use, (2) Pre-test with demand to use a table, and (3) Post-test (after participants received instruction on table use for problem solving). Although table use increased in Phase 2, it was only in Phase 3 that such use led to increases in correct answers. In Phase 3, fNIRS measurements also indicated an increase in blood flow to the frontal area (DLPFC and VLPFC) of the brain usually associated with working memory activity. These results demonstrate important neurophysiological changes resulting from task-appropriate instruction that promotes effective strategy use and improves learning performance.

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Section: Purpose and Rationale Of The Present Studymentioning

confidence: 99%

Brain imaging provides insights about the interaction between instruction and diagram use for mathematical word problem solving

et al. 2022

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“…Still, there are considerations that could affect the viability of using a functional connectome. For instance, fMRI, which is required for functional connectome construction requires sizeable infrastructure and administrative constraints that may impede on its accessibility to patients (Sakai, 2022).…”

Section: Connectomics-based Approachmentioning

confidence: 99%

Differentiation of Recurrent Glioblastoma Multiforme and Radiation Necrosis using Magnetic Resonance Imaging and Computerized Approaches: A Review

Paradkar

2022

BRAIN

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Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor originating from glial cells that is a subset of higher-grade gliomas (HGG). Given the extreme malignancy of GBM and HGG, radiotherapy is often used to shrink tumor and inhibit tumor cell function. Despite the use of radiotherapy, GBM recurrence rates remain high, and complications, such as radiation necrosis, can arise. Recurrent GBM and radiation necrosis are nearly indistinguishable using current imaging techniques, which is a considerable challenge in management of GBM treatment. Radiation necrosis is treated conservatively using corticosteroids while recurrent GBM requires aggressive treatments given its markedly short prognosis. Currently, invasive biopsy is the only available method for accurate differentiation of recurrent GBM from radiation necrosis. Clearly, noninvasive differentiation techniques are imperative to effective clinical decision-making surrounding GBM treatment. Many studies have attempted to use conventional MRI, advanced MRI parameters, modalities, and techniques, and machine learning methods to solve this crucial problem. In this review, we attempt to overview the difficulty of differential diagnosis and analyze the current state of knowledge on image-based differentiation approaches utilizing MRI. We identify major gaps in the research and make suggestions to improve current tactics and direct future investigations.

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“…Positron emission tomography (PET) scans utilize specialized tracers to directly reveal brain metabolism and oxygen consumption. While PET and fMRI offer millimeter-scale resolution and NIRS offers centimeter-scale resolution 14,15,16 , NIRS, with its lower cost and higher temporal resolution 15,17,18 , still cannot replace direct PbtO2 monitoring for TBI or SAH patients 19,20,21 . Commonly used methods for monitoring PbtO2 include polarography using Clark-type electrodes and optical methods based on luminescence quenching of oxygen-sensitive probes 13,22 .…”

Section: Introductionmentioning

confidence: 99%

An implantable optoelectronic probe for monitoring brain tissue oxygenation

Cai,

Sheng

2024

Neural Imaging and Sensing 2024

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The monitoring of partial pressure of oxygen in brain tissue (PbtO2) holds paramount importance in both neuroscience research and the management of brain-related disorders. While imaging techniques offer avenues to directly or indirectly assess brain oxygenation, their applicability is limited in the study of certain disease models involving behaving animals. Here, we present an optoelectronic probe for real-time and continuous PbtO2 monitoring, offering wireless capabilities and providing high temporal and spatial resolutions. This probe measures oxygen partial pressure (PO2) through phosphorescence quenching, and the implantable probe integrates a micro-scale violet light-emitting diode (LED), a thinfilm filter, a micro-scale photodetector, and an oxygen-sensing film. An implantable optoelectronic probe and a wireless control circuit miniaturized to centimeter scales form a system for monitoring PbtO2. Implanted into the brain of rats, this battery-free system demonstrates efficacy in capturing PbtO2 changes in response to alterations in the fraction of inspired oxygen (FiO2).

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Functional near-infrared spectroscopy reveals brain activity on the move

Cited by 17 publications

References 12 publications

Brain imaging provides insights about the interaction between instruction and diagram use for mathematical word problem solving

Brain imaging provides insights about the interaction between instruction and diagram use for mathematical word problem solving

Differentiation of Recurrent Glioblastoma Multiforme and Radiation Necrosis using Magnetic Resonance Imaging and Computerized Approaches: A Review

An implantable optoelectronic probe for monitoring brain tissue oxygenation

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