Functional near Infrared Spectroscopy in Psychiatry: A Critical Review

Ernst, Lena H.; Schneider, Sabrina; Ehlis, Ann‐Christine; Fallgatter, Andreas J.

doi:10.1255/jnirs.970

Cited by 29 publications

(19 citation statements)

References 111 publications

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“…Both observed more activated channels in the older group when contrasting TMT-B with TMT-A [38,39], similar to the results found in this study. However, as an imaging method, fNIRS has restricted spatial resolution and can only measure activity 1.5 cm deep into the cortex of the brain, which can limit precision when identifying activated brain areas [52]. Functional MRI is advantageous in comparison because activity is measured with millimetre spatial resolution throughout the entire brain volume, as appropriate for studying the TMT.…”

Section: Plos Onementioning

confidence: 99%

Functional magnetic resonance imaging of the trail-making test in older adults

et al. 2020

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The trail-making test (TMT) is a popular neuropsychological test, which is used extensively to measure cognitive impairment associated with neurodegenerative disorders in older adults. Behavioural performance on the TMT has been investigated in older populations, but there is limited research on task-related brain activity in older adults. The current study administered a naturalistic version of the TMT to a healthy older-aged population in an MRI environment using a novel, MRI-compatible tablet. Functional MRI was conducted during task completion, allowing characterization of the brain activity associated with the TMT. Performance on the TMT was evaluated using number of errors and seconds per completion of each link. Results are reported for 36 cognitively healthy older adults between the ages of 52 and 85. Task-related activation was observed in extensive regions of the bilateral frontal, parietal, temporal and occipital lobes as well as key motor areas. Increased age was associated with reduced brain activity and worse task performance. Specifically, older age was correlated with decreased task-related activity in the bilateral occipital, temporal and parietal lobes. These results suggest that healthy older aging significantly affects brain function during the TMT, which consequently may result in performance decrements. The current study reveals the brain activation patterns underlying TMT performance in a healthy older aging population, which functions as an important, clinically-relevant control to compare to pathological aging in future investigations.

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Section: Plos Onementioning

confidence: 99%

Functional magnetic resonance imaging of the trail-making test in older adults

et al. 2020

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“…The neural activity in cerebral cortex is associated with high level functions such as motion, sensation, perception, speaking, etc. This makes it suitable for fNIRS to be used as a substantial aid in diagnosing even complex problems, e.g., in psychiatry [114]. Moreover, fNIRS provides valuable research data indispensable for advancing neuroscience and our basic understanding of the higher functions of brain and improving rehabilitation therapies [115].…”

Section: Introduction To Functional Nir Spectroscopy (Fnirs)mentioning

confidence: 99%

Near-Infrared Spectroscopy in Bio-Applications

2020

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Near-infrared (NIR) spectroscopy occupies a specific spot across the field of bioscience and related disciplines. Its characteristics and application potential differs from infrared (IR) or Raman spectroscopy. This vibrational spectroscopy technique elucidates molecular information from the examined sample by measuring absorption bands resulting from overtones and combination excitations. Recent decades brought significant progress in the instrumentation (e.g., miniaturized spectrometers) and spectral analysis methods (e.g., spectral image processing and analysis, quantum chemical calculation of NIR spectra), which made notable impact on its applicability. This review aims to present NIR spectroscopy as a matured technique, yet with great potential for further advances in several directions throughout broadly understood bio-applications. Its practical value is critically assessed and compared with competing techniques. Attention is given to link the bio-application potential of NIR spectroscopy with its fundamental characteristics and principal features of NIR spectra.

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“…NIRS has several clear advantages for studying children with developmental disorders (Ernst, Schneider, Ehlis, & Fallgatter, 2012;Fukuda, 2009;Ichikawa et al, 2014). Compared to other neuroimaging techniques such as fMRI, NIRS is completely silent, providing a non-intrusive environment and requiring less stabilization of the body and head.…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic response of children with attention-deficit and hyperactive disorder (ADHD) to emotional facial expressions

et al. 2014

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a b s t r a c tChildren with attention-deficit/hyperactivity disorder (ADHD) have difficulty recognizing facial expressions. They identify angry expressions less accurately than typically developing (TD) children, yet little is known about their atypical neural basis for the recognition of facial expressions. Here, we used nearinfrared spectroscopy (NIRS) to examine the distinctive cerebral hemodynamics of ADHD and TD children while they viewed happy and angry expressions. We measured the hemodynamic responses of 13 ADHD boys and 13 TD boys to happy and angry expressions at their bilateral temporal areas, which are sensitive to face processing. The ADHD children showed an increased concentration of oxy-Hb for happy faces but not for angry faces, while TD children showed increased oxy-Hb for both faces. Moreover, the individual peak latency of hemodynamic response in the right temporal area showed significantly greater variance in the ADHD group than in the TD group. Such atypical brain activity observed in ADHD boys may relate to their preserved ability to recognize a happy expression and their difficulty recognizing an angry expression. We firstly demonstrated that NIRS can be used to detect atypical hemodynamic response to facial expressions in ADHD children.

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Functional near Infrared Spectroscopy in Psychiatry: A Critical Review

Cited by 29 publications

References 111 publications

Functional magnetic resonance imaging of the trail-making test in older adults

Functional magnetic resonance imaging of the trail-making test in older adults

Near-Infrared Spectroscopy in Bio-Applications

Hemodynamic response of children with attention-deficit and hyperactive disorder (ADHD) to emotional facial expressions

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