Functional Near-Infrared Spectroscopy

Cooper, Robert J.; Boas, David A.

doi:10.1016/b978-0-12-397025-1.00016-6

Cited by 3 publications

(1 citation statement)

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“…Activated neurons increase the demand for oxygen and manifest a rise in hemodynamic responses. However, due to the imbalanced nature between the consumption rate of oxygen and the corresponding increase in localized cerebral blood flow, classic hemodynamic response function incorporates both an increase in oxyhemoglobin concentration and a decrease in deoxyhemoglobin concentration [28]. Resting-state functional connectivity (rsFC) examines the statistical relationship between the measures of activity in discrete brain regions during rest [29].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Monotherapy and Combination Therapy with Acupuncture in Depressed Patients: A Resting-State Functional Near-Infrared Spectroscopy (fNIRS) Study

et al. 2021

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Depression is a common psychiatric illness affecting over 300 million people globally. Acupuncture has been reported to be a safe complementary treatment for depression. This study is aimed to investigate the efficacy and mechanism of combining acupuncture with antidepressants in treating depression compared to the sole use of antidepressants. Seventy depression patients were randomly assigned to the treatment group (n = 50) and control group (n = 20). The treatment group received acupuncture combined antidepressants treatment for 3 weeks, while the control group took antidepressants monotherapy for 3 weeks. Among the 70 patients, 40 participants (20 control; 20 treatment) were randomized for studying functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC) measured by the functional near-infrared spectroscopy. The primary outcome was HAMD-17 and secondary outcomes were PHQ-9, and the relationships of resting-state FC (rsFC) with the depression severity. PHQ-9 and HAMD-17 scores in the treatment group were significantly lower than those in the control group at Week 3 (p = 0.01) with effect sizes of −0.4 and −0.61 respectively. The rsFC in F1, F3, AF3, AF7, FC3, FC5 (left DLPFC, 10-20 system), AF8, and F6 (right DLPFC) in the treatment group had significant temporal correlation (p < 0.05, FDR corrected) in DLPFC compared to the channels in the control group. No significant correlation was found between the changes of rsFC and depression severity. In conclusion, depressed patients receiving acupuncture combined with antidepressants have improvement of depressive symptoms and the stronger rsFC in the DLPFC compared to those using antidepressants alone.

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Section: Discussionmentioning

confidence: 99%