Functional Nanoparticles from Dendritic Precursors: Hierarchical Assembly in Miniemulsion

Sisson, Adam L.; Papp, Ilona; Landfester, Katharina; Haag, Rainer

doi:10.1021/ma802238e

Cited by 60 publications

(50 citation statements)

References 25 publications

(29 reference statements)

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“…[133] The concept was to cross-link existing hyperbranched PG (2-3 nm diameter, MW 5 kDa) to higher homologues using the miniemulsion polymerization technique, whereby the surfactant-stabilized dispersed droplets act as ''nanoreactors.'' The hyperbranched PG monomers were converted to their highmolecular-weight variant using the nanoreactor template, whereas cross-linking was achieved by an easy ''click''-type Huisgen alkyne/azide cycloaddition.…”

Section: Block Copolymers Of Polyglycerolmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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Section: Block Copolymers Of Polyglycerolmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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“…For the A 2 +B 2 system there was just a tiny peak at  = 80 ppm in 13 C-NMR spectrum (Fig. 3c) caused by dendritic C-H units.…”

Section: Degree Of Crosslinking and Degree Of Branchingmentioning

confidence: 99%

“…Recently, our group reported polyglycerol nanogels with controllable sizes that were between 25 and 85 nm in diameter using inexpensive, commercially available monomers [11,12] or dendritic precursors [13] in miniemulsion. Degradable particles have also been obtained [14].…”

Section: Introductionmentioning

confidence: 99%

“…They can be fabricated by shearing a system containing two immiscible liquids, a surfactant, and an osmotic pressure agent, which is soluble in the dispersed phase but not in the continuous phase [19]. After rapid stirring and treatment with a sonicator the mixture becomes a dispersion containing rather monodisperse droplets of 50-500 nm in diameter [11,13]. Each droplet acts as a discrete nanoreactor vessel, in which polymerization takes place.…”

Section: Introductionmentioning

confidence: 99%

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Glycerol based polyether-nanogels with tunable properties via acid-catalyzed epoxide-opening in miniemulsion

Zhou¹,

Steinhilber²,

Schlaad³

et al. 2011

Reactive and Functional Polymers

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A series of defined nanogels of 20-120 nm in diameter were synthesized by acidcatalyzed epoxid-opening polymerization based on glycerol in miniemulsion.Multifunctional alcohols were used as monomers and di-and triepoxides as crosslinking agents. The properties of these nanogels, i.e., size, degree of branching, viscosity, and swelling behavior, can be controlled by varying the functionalities of the monomers and crosslinkers. Inverse gated 13 C-NMR indicated that the addition of monomer occurred at both ends of the opened epoxide ring of the crosslinkers. This feature led to higher degree of branching and consequently to a lower viscosity of the resulting nanogels. The formation of some cycles as a possible side reaction was evidenced by different particle sizes in dry (TEM) and swollen states (DLS in water). KeywordsGlycerol based nanogel, inverse miniemulsion, watersoluble nanogels intrinsic viscosity, degree of branching, particle size 3

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“…32). 199 Dye or drug molecules can be encapsulated in the nanoparticles either covalently or physically in the dispersed phase before the crosslinking polymerization. By using these miniemulsion polymerization techniques, polyglycerol nanogels on previously unavailable length scales can be obtained.…”

Section: Toward Biomedical Applicationsmentioning

confidence: 99%

Hyperbranched aliphatic polyether polyols

Schömer

Schüll

Frey

2012

J. Polym. Sci. A Polym. Chem.

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Hyperbranched polymers, dendritic macromolecules with branch-on-branch structures, have become an important polymer class since the early 1990s. They combine several advantages of the perfectly branched dendrimers with easy accessibility, typically in a one-step synthesis. Hyperbranched polyethers are a particularly interesting class of chemically stable and often biocompatible materials. Multifunctional hyperbranched polyethers with controllable molar mass and comparably low polydispersities can been prepared using hydroxyl-functional epoxides or oxetanes for polymerization via anionic and cationic polymerization mechanisms. Here, we review the progress in the preparation, characterization, and application of these uniquely versatile aliphatic polyether polyols. Their unusual mechanical, thermal, and solution properties render them useful for a variety of applications, for example, as building blocks for various complex macromolecular architectures or in biomedical applications.

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Functional Nanoparticles from Dendritic Precursors: Hierarchical Assembly in Miniemulsion

Cited by 60 publications

References 25 publications

Dendritic Polyglycerols for Biomedical Applications

Dendritic Polyglycerols for Biomedical Applications

Glycerol based polyether-nanogels with tunable properties via acid-catalyzed epoxide-opening in miniemulsion

Hyperbranched aliphatic polyether polyols

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