Functional Nanomaterials for Rapid Detection of SARS-CoV-2: a Review

Abstract

Since 2019, the pandemic outbreak of COVID-19 caused by persistent transmission and infection of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a threat to public health globally, and the rapid and accurate identification of viruses is crucial for controlling COVID-19. In recent years, nanomaterial-based electrochemical sensing techniques hold immense potential for molecular diagnosis with high sensitivity and specificity.In this paper, we briefly introduced the structural characteristics and routine detection methods of SARS-CoV-2, then summarized the associated properties and mechanisms of the electrochemical biosensing methods. On the above basis, the research progress of electrochemical sensors constructed form gold nanomaterials, oxide nanomaterials, carbonbased nanomaterials and other nanomaterials for rapid and accurate detection of virus were reviewed. Finally, the future applications of nanomaterial-based biosensors in biomolecular diagnostics were conjectured.