Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

Zhang, Maojie; Cao, Qiang; Yuan, Yupeng; Guo, Xiaohan; Pan, Dawei; Xie, Rui; Ju, Xiao‐Jie; Liu, Zhuang; Wang, Wei; Chu, Liang‐Yin

doi:10.1016/j.cclet.2023.108710

Cited by 3 publications

(2 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nano-emulsions are typically heterogeneous systems composed of oil and water, characterized by good transparency, a large specific surface area, high stability and adjustable rheological properties. 82 Besides, nano-emulsions can improve the bioavailability and stability of lipophilic drugs, 83 making them widely used in delivery systems. Based on the theory of “unification of drugs and excipients”, Li et al 59 prepared a nano-emulsion (TSE-BJO NEs) loaded with TS extract (TSE) and brucea oil (BJO).…”

Section: Passive Targeted Drug Delivery Systemmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

View full text Add to dashboard Cite

Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

show abstract

Section: Passive Targeted Drug Delivery Systemmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…Because of their non-Newtonian nature, nanoemulsions can be designed into various biopharmaceutical delivery systems for active ingredients, including creams, gels, foams, ointments, with a broad spectrum of administration in topical, transdermal, ophthalmic, and nasal routes. [23] Scientists developed nanoformulations containing Clinacanthus nutans leaf extract for the treatment of post-herpetic neuralgia, a complication of herpes zoster. In vitro studies of the formulations as well as physicochemical properties ensured stability and permeability within parameters, characterizing them as candidate creams for topical use in therapeutics.…”

Section: Nanoemulsionsmentioning

confidence: 99%

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Because of the increasing demand for natural products, the development of nanoformulations containing natural active ingredients requires in‐depth knowledge of the substances used, methods of obtaining, and stability profiles to ensure product quality, efficacy, and safety. Considering this, the bibliography of the last five years presented in databases (PubMed and Science Direct) was discussed in this work, discussing the study with medicinal plants to obtain active metabolites with therapeutic properties, as well as the different nano‐systems responsible for carrying these molecules. Due to the wealth of biodiversity found in the world, many species are submitted to the extraction process for several purposes. However, identifying, classifying, and quantifying the constituents of herbal matrices are crucial steps to verify their therapeutic potential. In addition, knowing the techniques of production and elaboration of nanotechnology products allows the optimization of the incorporation of herbal extracts as an innovation target. For studies to be successful, it is necessary to exhaust experimental results that guarantee the efficacy, safety, and quality of natural nanosystems, with the objective of obtaining reliable answers in nanotechnology therapy.

show abstract

Vesicular drug delivery systems for oral absorption enhancement

Zou,

Cheng,

et al. 2024

Chinese Chemical Letters

View full text Add to dashboard Cite

Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

Cited by 3 publications

References 100 publications

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Vesicular drug delivery systems for oral absorption enhancement

Contact Info

Product

Resources

About