Functional MRI shows activation of the medial preoptic area during sleep

Khubchandani, M.; Jagannathan, Naranamangalam R.; Mallick, Hruda Nanda; Kumar, Velayudhan Mohan

doi:10.1016/j.neuroimage.2005.01.002

Cited by 29 publications

(13 citation statements)

References 26 publications

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“…In fact, our observations indicate that the numbers of c-Fos labeled cells in the medial preoptic area (mPOA), as well as some parts of the BF, were relatively higher compared to the VLPOA and MnPOA. Also notable is a study using functional magnetic resonance imaging (fMRI) in the behaving rats that elegantly demonstrated the mPOA is more active than other parts of the hypothalamus and BF during SWS (Khubchandani et al, 2005). The results of a few studies suggest that small lesions in the VLPOA and MnPOA effectively suppressed SWS (Gerashchenko et al, 2003;Lu et al, 2000); however, similar lesion experiments in our laboratory demonstrated only a slight reduction in SWS that lasted approximately 2 days.…”

Section: Mechanisms For the Generation And Maintenance Of Swsmentioning

confidence: 72%

Neurobiological mechanisms for the regulation of mammalian sleep–wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence

Datta

MacLean

2007

Neuroscience & Biobehavioral Reviews

268

249

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At its most basic level, the function of mammalian sleep can be described as a restorative process of the brain and body; recently, however, progressive research has revealed a host of vital functions to which sleep is essential. Although many excellent reviews on sleep behavior have been published, none have incorporated contemporary studies examining the molecular mechanisms that govern the various stages of sleep. Utilizing a holistic approach, this review is focused on the basic mechanisms involved in the transition from wakefulness, initiation of sleep and the subsequent generation of slow-wave sleep and rapid eye movement (REM) sleep. Additionally, using recent molecular studies and experimental evidence that provides a direct link to sleep as a behavior, we have developed a new model, the cellular-molecular-network model, explaining the mechanisms responsible for regulating REM sleep. By analyzing the fundamental neurobiological mechanisms responsible for the generation and maintenance of sleep-wake behavior in mammals, we intend to provide a broader understanding of our present knowledge in the field of sleep research.

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Section: Mechanisms For the Generation And Maintenance Of Swsmentioning

confidence: 72%

Neurobiological mechanisms for the regulation of mammalian sleep–wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence

Datta

MacLean

2007

Neuroscience & Biobehavioral Reviews

268

249

View full text Add to dashboard Cite

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“…On the other hand, some patients with lesion in the anterior hypothalamic-POA (POAH) had insomnia. The concept of the POA as a sleep-promoting area and the posterior hypothalamus as the wake promoting area was supported by several lines of animal experiments employing stimulation, lesion, single unit recording, neural transplantation, functional magnetic resonance imaging (fMRI), and c-fos studies (Nauta, 1946; Sterman and Clemente, 1962; McGinty and Sterman, 1968; Szymusiak and McGinty, 1986; John et al, 1994, 1998; Sherin et al, 1996; John and Kumar, 1998; Khubchandani et al, 2005). Electrical stimulation of BF was shown to produce drowsiness followed by natural behavioral and electroencephalographic sleep (Sterman and Clemente, 1962).…”

Section: Sleep Regulationmentioning

confidence: 99%

Basal Forebrain Thermoregulatory Mechanism Modulates Auto-Regulated Sleep

Mallick¹,

Kumar²

2012

Front. Neur.

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Regulation of body temperature and sleep are two physiological mechanisms that are vital for our survival. Interestingly neural structures implicated in both these functions are common. These areas include the medial preoptic area (POA), the lateral POA, the ventrolateral POA, the median preoptic nucleus, and the medial septum, which form part of the basal forebrain (BF). When given a choice, rats prefer to stay at an ambient temperature of 27°C, though the maximum sleep was observed when they were placed at 30°C. Ambient temperature around 27°C should be considered as the thermoneutral temperature for rats in all sleep studies. At this temperature the diurnal oscillations of sleep and body temperature are properly expressed. The warm sensitive neurons of the POA mediate the increase in sleep at 30°C. Promotion of sleep during the rise in ambient temperature from 27 to 30°C, serve a thermoregulatory function. Autonomous thermoregulatory changes in core body temperature and skin temperature could act as an input signal to modulate neuronal activity in sleep-promoting brain areas. The studies presented here show that the neurons of the BF play a key role in regulating sleep. BF thermoregulatory system is a part of the global homeostatic sleep regulatory mechanism, which is auto-regulated.

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“…Utilizing single cell recording techniques, various researchers have identified a large population of cells within the POA that are more active during the electrophysiological and behavioral signs of SWS than during wakefulness or REM sleep [63-73]. Consistent with these single cell recording studies, a study using functional magnetic resonance imaging (fMRI) in the behaving rat has demonstrated that the POA is more active than other parts of the hypothalamus and basal forebrain during SWS [74]. A number of local microinjection studies have supported the critical role of the POA in the generation of SWS [75-79].…”

Section: Neural Mechanisms Of Swsmentioning

confidence: 99%

Cellular and chemical neuroscience of mammalian sleep

Datta

2010

Sleep Medicine

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Extraordinary strides have been made toward understanding the complexities and regulatory mechanisms of sleep over the past two decades, thanks to the help of rapidly evolving technologies. At its most basic level, mammalian sleep is a restorative process of the brain and body. Beyond its primary restorative purpose, sleep is essential for a number of vital functions. Our primary research interest is to understand the cellular and molecular mechanisms underlying the regulation of sleep and its cognitive functions. Here I will reflect on our own research contributions to fifty years of extraordinary advances in the neurobiology of slow-wave sleep (SWS) and rapid eye movement (REM) sleep regulation. I conclude this review by suggesting some potential future directions to further our understanding of the neurobiology of sleep.

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Functional MRI shows activation of the medial preoptic area during sleep

Cited by 29 publications

References 26 publications

Neurobiological mechanisms for the regulation of mammalian sleep–wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence

Neurobiological mechanisms for the regulation of mammalian sleep–wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence

Basal Forebrain Thermoregulatory Mechanism Modulates Auto-Regulated Sleep

Cellular and chemical neuroscience of mammalian sleep

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