Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization

Malisza, Krisztina L.; Stroman, Patrick W.; Turner, Allan; Gregorash, Lori; Foniok, Tadeusz; Wright, Anthony

doi:10.1002/jmri.10339

Cited by 57 publications

(40 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent to mobilization,there was decreased activation of the dorsal horn. 41 By analogy, upper cervical afferents may have an excitatory influence on trigeminal circuits in migraine sufferers that can be reduced by reproduction and lessening of usual head pain.…”

Section: Discussionmentioning

confidence: 99%

Cervical Referral of Head Pain in Migraineurs: Effects on the Nociceptive Blink Reflex

Watson

Drummond

2014

Headache

View full text Add to dashboard Cite

Objective.-To investigate cervical, interictal reproduction of usual head pain and its effect on the nociceptive blink reflex in migraineurs.Background.-Anatomical and neurophysiological studies in animals and humans have confirmed functional convergence of trigeminal and cervical afferent pathways. Migraineurs often present with occipital and neck symptoms, and cervical pain is referred to the head in most cases, suggesting that cervical afferent information may contribute to headache. Furthermore, the effectiveness of greater occipital nerve blockade in migraine and demonstrable modulation of trigeminal transmission following greater occipital nerve blockade suggest an important role for cervical afferents in migraine. However, to what extent cervical afferents contribute actively to migraine is still unknown.Methods.-The passive accessory intervertebral movements of the atlanto-occipital and C2-3 spinal segments of 15 participants (14 females, 1 male; age 24-44 years, mean age 33.3 years) with migraine were examined interictally. During 1 session, either the atlanto-occipital or C2-3 segment was examined, resulting in referred usual head pain, while in another session, pressure was applied over the common extensor origin (lateral epicondyle of the humerus) of the ipsilateral arm. Each intervention was repeated 4 times. The nociceptive blink reflex to a supraorbital electrical stimulus was elicited ipsilaterally during both sessions before and during each intervention. The main outcome variables were the number of recorded blinks, area under the curve and latencies of the R2 components of the nociceptive blink reflex. Participants also rated the intensity of referred head pain and the supraorbital stimulus on a scale of 0-10, where 0 = "no pain" and 10 = "intolerable pain," and rated the intensity of applied pressure where 0 = "pressure but no pain" and 10 = "intolerable pain."Results.-Participants reported a significant reduction in local tenderness ratings across the 4 trials for the cervical intervention but not for the arm (P = .005). The cervical intervention evoked head pain in all participants. As the cervical intervention was sustained, head pain decreased significantly from the beginning to the end of each trial (P = .000) and from the beginning of the first trial to the end of the last (P = .000). Pain evoked by the supraorbital stimulus was consistent from baseline to across the 4 trials (P = .635) and was similar for the cervical and arm interventions (P = .072). The number of blinks decreased significantly across the experiment (P = .000) and was comparable in the cervical and arm interventions (P = .624). While the R2 area under the curve decreased irrespective of intervention (P = .000), this reduction was significantly greater for the cervical intervention than when pressure was applied to the arm (P = .037). Analysis of the R2 latencies revealed a notable increase across the experiment (P = .037). However, this increase was significantly greater following the cervical than arm intervention (P ...

show abstract

Section: Discussionmentioning

confidence: 99%

Cervical Referral of Head Pain in Migraineurs: Effects on the Nociceptive Blink Reflex

Watson

Drummond

2014

Headache

View full text Add to dashboard Cite

show abstract

“…A slice package consisted of seven adjacent axial slices with 2.1 mm thickness and a field of view of 20 mm. This was centered at vertebra L1 (Malisza et al, 2003). The same geometry was used both for the collection of fMRI data and anatomical high-resolution images.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, fMRI of the spinal cord has been shown technically feasible in both humans and rats (Malisza et al, 2003;Stroman et al, 2003b;Majcher et al, 2006). In humans, the establishment of this technique should allow noninvasive assessment of spinal cord activity.…”

Section: Introductionmentioning

confidence: 99%

Blood Oxygenation Level-Dependent Visualization of Synaptic Relay Stations of Sensory Pathways along the Neuroaxis in Response to Graded Sensory Stimulation of a Limb

Lilja

Endo

Hofstetter

et al. 2006

Journal of Neuroscience

View full text Add to dashboard Cite

Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to test at which levels of the neuroaxis signals are elicited when different modalities of sensory information from the limbs ascend to cortex cerebri. We applied graded electric stimuli to the rat hindlimbs and used echo-planar imaging to monitor activity changes in the lumbar spinal cord and medulla oblongata, where primary afferents of painful and nonpainful sensation synapse, respectively. BOLD signals were detected in ipsilateral lumbar spinal cord gray matter using sufficiently strong stimuli. Using stimuli well below the threshold needed for signals to be elicited in the spinal cord, we found BOLD responses in dorsal medulla oblongata. The distribution of these signals is compatible with the neuroanatomy of the respective synaptic relay stations of the corresponding sensory pathways. Hence, the sensory pathways conducting painful and nonpainful information were successfully distinguished. The fMRI signals in the spinal cord were markedly decreased by morphine, and these effects were counteracted by naloxone. We conclude that fMRI can be used as a reliable and valid method to monitor neuronal activity in the rat spinal cord and medulla oblongata in response to sensory stimuli. Previously, we also documented BOLD signals from thalamus and cortex. Thus, BOLD responses can be elicited at all principal synaptic relay stations along the neuroaxis from lumbar spinal cord to sensory cortex. Rat spinal cord fMRI should become a useful tool in experimental spinal cord injury and pain research.

show abstract

“…5,6,19,38,39,50,51,62,63,68 Previous studies have used functional magnetic resonance imaging (fMRI) to measure hemodynamic displacement to structures within the brain over time, serving as a local measure of cognitive, sensory, or motor processes. 12,28,35,40 With this method, functional images are overlaid atop higher-resolution anatomic images, allowing inferences to be made regarding neural activity within the brain.…”

Section: T T Conclusionmentioning

confidence: 99%

Using Functional Magnetic Resonance Imaging to Determine if Cerebral Hemodynamic Responses to Pain Change Following Thoracic Spine Thrust Manipulation in Healthy Individuals

Sparks

Cleland

Elliott³

et al. 2013

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

[ research report ] R ecently, in the physical therapy profession con siderable attention has been devoted to exam ining the effectiveness of spinal manipulation in clinical practice. 9,15,16,24,65 The use of thrust manipulation applied to the thoracic spine has been shown to result in increased range of motion, decreased pain, and improvements in function in subgroups of individuals with mechanical neck and shoulder pain. [13][14][15][16]23,43,62,65 Biomechanical theories to explain the effects of spinal manipulation exist, yet the available data do not sufficiently explain how manipulation results in short-or long-term clinical benefits. 20,34,47,56 Researchers have attempted to identify which combination of clinical signs, symptoms, and other pertinent findings from the examination may predict a favorable response to spinal manipulation. 13,43,57 A validation study of a proposed clinical decision rule to identify patients likely to respond to thoracic manipulation found that subjects with mechanical neck pain improved with T T STUDY DESIGN: Case series. T T OBJECTIVES:To use blood oxygenation leveldependent functional magnetic resonance imaging (fMRI) to determine if supraspinal activation in response to noxious mechanical stimuli varies preand post-thrust manipulation to the thoracic spine. T T BACKGROUND:Recent studies have demonstrated the effectiveness of thoracic thrust manipulation in reducing pain and improving function in some individuals with neck and shoulder pain. However, the mechanisms by which manipulation exerts such effects remain largely unexplained. The use of fMRI in the animal model has revealed a decrease in cortical activity in response to noxious stimuli following manual joint mobilization. Supraspinal mediation contributing to hypoalgesia in humans may be triggered following spinal manipulation. T T METHODS: Ten healthy volunteers (5 women, 5men) between the ages of 23 and 48 years (mean, 31.2 years) were recruited. Subjects underwent fMRI scanning while receiving noxious stimuli applied to the cuticle of the index finger at a rate of 1 Hz for periods of 15 seconds, alternating with periods of 15 seconds without stimuli, for a total duration of 5 minutes. Subjects then received a supine thrust manipulation directed to the midthoracic spine and were immediately returned to the scanner for reimaging with a second delivery of noxious stimuli. An 11-point numeric pain rating scale was administered immediately after the application of noxious stimuli, premanipulation and postmanipulation. Blood oxygenation level-dependent fMRI recorded the cerebral hemodynamic response to the painful stimuli premanipulation and postmanipulation. T T RESULTS:The data indicated a significant reduction in subjects' perception of pain (P<.01), as well as a reduction in cerebral blood flow as measured by the blood oxygenation level-dependent response following manipulation to areas associated with the pain matrix (P<.05). There was a significant relationship between reduced activation in the insular cortex and d...

show abstract

Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization

Cited by 57 publications

References 34 publications

Cervical Referral of Head Pain in Migraineurs: Effects on the Nociceptive Blink Reflex

Cervical Referral of Head Pain in Migraineurs: Effects on the Nociceptive Blink Reflex

Blood Oxygenation Level-Dependent Visualization of Synaptic Relay Stations of Sensory Pathways along the Neuroaxis in Response to Graded Sensory Stimulation of a Limb

Using Functional Magnetic Resonance Imaging to Determine if Cerebral Hemodynamic Responses to Pain Change Following Thoracic Spine Thrust Manipulation in Healthy Individuals

Contact Info

Product

Resources

About