Functional MRI of the cortical sensorimotor system in patients with hereditary spastic paraplegia

Tomberg, Tiiu; Braschinsky, Mark; Rannikmäe, Kristiina; Kepler, J; Kepler, Kalle; Kõrv, Janika; Linnamägi, Ülla; Asser, Toomas

doi:10.1038/sc.2012.70

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…The indirect evidence of such connection is derived from studies that report two types of findings. First, some found that greater spasticity was correlated with diminished activation in sensory regions [41]. Second, some found that spasticity treatment was associated with changes in sensory network function [16, 19, 42].…”

Section: Discussionmentioning

confidence: 99%

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors

Pundik

Falchook

McCabe

et al. 2014

Stroke Research and Treatment

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Background. Arm spasticity is a challenge in the care of chronic stroke survivors with motor deficits. In order to advance spasticity treatments, a better understanding of the mechanism of spasticity-related neuroplasticity is needed. Objective. To investigate brain function correlates of spasticity in chronic stroke and to identify specific regional functional brain changes related to rehabilitation-induced mitigation of spasticity. Methods. 23 stroke survivors (>6 months) were treated with an arm motor learning and spasticity therapy (5 d/wk for 12 weeks). Outcome measures included Modified Ashworth scale, sensory tests, and functional magnetic resonance imaging (fMRI) for wrist and hand movement. Results. First, at baseline, greater spasticity correlated with poorer motor function (P = 0.001) and greater sensory deficits (P = 0.003). Second, rehabilitation produced improvement in upper limb spasticity and motor function (P < 0.0001). Third, at baseline, greater spasticity correlated with higher fMRI activation in the ipsilesional thalamus (rho = 0.49, P = 0.03). Fourth, following rehabilitation, greater mitigation of spasticity correlated with enhanced fMRI activation in the contralesional primary motor (r = −0.755, P = 0.003), premotor (r = −0.565, P = 0.04), primary sensory (r = −0.614, P = 0.03), and associative sensory (r = −0.597, P = 0.03) regions while controlling for changes in motor function. Conclusions. Contralesional motor regions may contribute to restoring control of muscle tone in chronic stroke.

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Section: Discussionmentioning

confidence: 99%

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors

Pundik

Falchook

McCabe

et al. 2014

Stroke Research and Treatment

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“…There are 3 studies using fMRI in subjects with HSP (39, 46, 47). In 2 of them, authors employed a motor task to investigate how different cerebral regions are activated in the disease (39, 47). Both studies found abnormal primary motor cortex activation in patients with HSP in comparison to healthy controls; surprisingly, one study found increased whereas the other found reduced activation.…”

Section: Advanced Mri In Hsp: Understanding Pathophysiology and Potenmentioning

confidence: 99%

Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives

et al. 2019

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Hereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts and dorsal columns. Genotypic and phenotypic heterogeneity is a hallmark of this group of diseases, which makes proper diagnosis and management often challenging. In this scenario, magnetic resonance imaging (MRI) emerges as a valuable tool to assist in the exclusion of mimicking disorders and in the detailed phenotypic characterization. Some neuroradiological signs have been reported in specific subtypes of HSP and are therefore helpful to guide genetic testing/interpretation. In addition, advanced MRI techniques enable detection of subtle structural abnormalities not visible on routine scans in the spinal cord and brain of subjects with HSP. In particular, quantitative spinal cord morphometry and diffusion tensor imaging look promising tools to uncover the pathophysiology and to track progression of these diseases. In the current review article, we discuss the current use and future perspectives of MRI in the context of HSP.

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“…There are no published papers describing neuroimaging findings in patient with KIF5A-ALS. Only one previous work using functional brain MRI described the involvement of the supplementary motor area in SPG-KIF5A patients ( Tomberg et al, 2012 ). The hypometabolism described in ALS10, restricted primarily to the motor region, supports the hypothesis of a predominantly motor involvement related to mutations in this gene, associated with a clinically evident upper motor neuron phenotype.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of single-subject brain metabolism patterns in amyotrophic lateral sclerosis mutation carriers

Tondo

Mazzini

Caminiti

et al. 2022

NeuroImage: Clinical

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Functional MRI of the cortical sensorimotor system in patients with hereditary spastic paraplegia

Abstract: Our results suggest changes in cortical sensorimotor network function in patients with HSP compared with healthy subjects. Lower activation in patients might reflect damage to the corticospinal tract, be influenced by compensatory mechanisms, and/or be a reflection of neurorehabilitation.

Cited by 12 publications

References 18 publications

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors

Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives

Clinical relevance of single-subject brain metabolism patterns in amyotrophic lateral sclerosis mutation carriers

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