Functional MRI in prenatally opioid-exposed children during a working memory-selective attention task

Sirnes, Eivind; Griffiths, Silja Torvik; Aukland, Stein Magnus; Eide, Geir Egil; Elgen, Irene Bircow; Gundersen, Hilde

doi:10.1016/j.ntt.2018.01.010

Cited by 31 publications

(20 citation statements)

References 106 publications

(94 reference statements)

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“…Two studies used magnetic resonance imaging (MRI) to examine brain structure and function (Sirnes et al, 2017, 2018). Results of structural MRI indicated no difference in global brain measures, but volumes of the basal ganglia, thalamus, and cerebellar white matter were significantly reduced in exposed children between 10 and 14 years of age compared to unexposed controls.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal Outcomes of Children Exposed to Opioids In‐utero: A Systematic Review

Arter

Tyler

McAllister

et al. 2020

J of Nursing Scholarship

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PurposeThe purpose was to summarize evidence of long‐term outcomes of children, 2 years and older, exposed to opioids in‐utero.DesignThis was a systematic review. Studies were identified by searching the following electronic databases: PubMed, EBSCO HOST/Medline, and Web of Science. Articles were published between 1979 and 2019.MethodsThis systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta‐Analysis. Two sets of two independent reviewers extracted data and assessed study quality according to National Institutes of Health quality assessment tools.ResultsForty‐three articles met inclusion criteria. Synthesis of articles identified trends toward worse outcomes for children with in‐utero opioid exposure in all areas, most notably related to academic success, behavior, cognition, hospitalizations, and vision.ConclusionsFindings reinforce the necessity of continued research in this area with improved study design. Despite limitations in the current body of evidence, findings from this review are vital knowledge for clinicians, because children exposed to opioids in‐utero are clearly vulnerable to a wide variety of suboptimal health and developmental outcomes.Clinical RelevanceRecognition of all outcomes across childhood associated with in‐utero opioid exposure will inform improved identification and interventions tailored to the most pressing needs of affected children. Despite the need for continued research, there is sufficient evidence to necessitate close, individualized follow‐up throughout childhood.

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Section: Resultsmentioning

confidence: 99%

“…Out of seven studies examining social emotional outcomes, only two used the same instrument (Levine & Woodward, 2018; Sundelin Wahlsten & Sarman, 2013), the Strengths and Difficulties Questionnaire (SDQ). One study reported worse scores for exposed children compared to the control on all SDQ subscales when rated by caregivers.…”

Section: Resultsmentioning

confidence: 99%

Longitudinal Outcomes of Children Exposed to Opioids In‐utero: A Systematic Review

Arter

Tyler

McAllister

et al. 2020

J of Nursing Scholarship

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“…Sixteen opiate-exposed children between 10–14 years of age (childhood moving into adolescence) demonstrated reductions in brain volume in the basal ganglia, thalamus, and cerebellar white matter when compared to 16 non-exposed children (Sirnes et al, 2017). A subsample of this group, with 12 opiate-exposed and 11 non-exposed, also performed a working memory task using Stroop stimuli (Sirnes et al, 2018). The opiate-exposed children showed less accuracy and slower reaction times.…”

Section: Childhood and Juvenile Stagesmentioning

confidence: 99%

Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging

Morie

Crowley

Mayes

et al. 2019

Drug and Alcohol Dependence

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Prenatal drug exposure may have important repercussions across the lifespan for cognition and behavior. While alcohol is a recognized teratogen, the influences of other substances may also be substantial. The neural underpinnings of the influences of prenatal drug exposure have been examined using longitudinal approaches and multiple imaging techniques. Here we review the existing literature on the neural correlates of prenatal drug exposure. We focused the review on studies that have employed functional neuroimaging and electroencephalography and on substances other than alcohol. We also framed the review through the lens of four developmental life stages (infancy, childhood, adolescence and emerging adulthood). We included papers that have examined any drug use, including tobacco, opiates, cocaine, marijuana, methamphetamines, or poly-substance use. Data suggest that prenatal drug exposure has long-lasting, deleterious influences on cognition and reward processing in infancy and childhood that persist into adolescence and emerging adulthood and may underlie some behavioral tendencies, such as increased externalizing and risk-taking behaviors, seen in these groups.

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“…Apart from nicotine and alcohol, other drugs of abuse seem to have detrimental effects on the developing brain-often reported as decreased brain volumes or altered functional maturation (Grant, Petroff, Isoherranen, Stella, & Burbacher, 2017;Sirnes et al, 2017Sirnes et al, , 2018.…”

Section: Tobacco and Drugs Of Abuse As Prenatal Exposuresmentioning

confidence: 99%

Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis

Pulli

Kumpulainen

Kasurinen

et al. 2018

Human Brain Mapping

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Brain development is most rapid during the fetal period and the first years of life. This process can be affected by many in utero factors, such as chemical exposures and maternal health characteristics. The goal of this review is twofold: to review the most recent findings on the effects of these prenatal factors on the developing brain and to qualitatively assess how those factors were generally reported in studies on infants up to 2 years of age. To capture the latest findings in the field, we searched articles from PubMed 2012 onward with search terms referring to magnetic resonance imaging (MRI), brain development, and infancy. We identified 19 MRI studies focusing on the effects of prenatal environment and summarized them to highlight the recent advances in the field. We assessed population descriptions in a representative sample of 67 studies and conclude that prenatal factors that have been shown to affect brain metrics are not generally reported comprehensively. Based on our findings, we propose some improvements for population descriptions to account for plausible confounders and in time enable reliable meta‐analyses to be performed. This could help the pediatric neuroimaging field move toward more reliable identification of biomarkers for developmental outcomes and to better decipher the nuances of normal and abnormal brain development.

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Functional MRI in prenatally opioid-exposed children during a working memory-selective attention task

Abstract: Our findings suggest that prenatal opioids affect later brain function, visible through changes in BOLD activation patterns. However, results should be considered preliminary until replicated in larger samples better suited to control for potential confounding factors.

Cited by 31 publications

References 106 publications

Longitudinal Outcomes of Children Exposed to Opioids In‐utero: A Systematic Review

Longitudinal Outcomes of Children Exposed to Opioids In‐utero: A Systematic Review

Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging

Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis

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