Functional MRI correlates of real and imagined tool-use pantomimes

Moll, Jorge; Oliveira‐Souza, Ricardo de; Passman, Leigh J.; Cunha, Fernando Cimini; Souza-Lima, Fabiana De; Andreiuolo, Pedro Ângelo

doi:10.1212/wnl.54.6.1331

Cited by 157 publications

(131 citation statements)

References 18 publications

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“…In previous neuroimaging studies, researchers asked participants to make pantomimes with both right and left hands and showed that the left-lateralized parietal and premotor networks are activated for both dominant and non-dominant hands (Moll et al 2000;Johnson and Grafton 2003;Johnson-Frey et al 2005). However, with a conventional subtraction method based on mass univariate analysis, it cannot be decided whether there is left IPL, which is consistent with the lesion cases of IMA (Buxbaum et al 2007;Binkofski and Buxbaum 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The difference between their study 20 results and the current results is that they showed almost an equal importance in the classification accuracy of bilateral PPC, whereas our results showed left-hemispheric dominance. Considering that a number of previous neuroimaging studies on tool use (Moll et al 2000;Choi et al 2001;Rumiati et al 2004;Fridman et al 2005;Johnson-Frey et al 2005;Imazu et al 2007) also showed left-hemisphere dominance, this discrepancy may be a result of the movement types. The difference in neural substrates between simple manual actions and tool use is also supported by the fact that IMA patients showed no impairments in visually guided grasping or reaching (Haaland et al 1999).…”

Section: Iplmentioning

confidence: 92%

“…Some of these studies used the movement of both right and left hands, and they revealed that the left-lateralized PPC and premotor network are activated for the pantomiming of both dominant and non-dominant hands (Moll et al 2000;Johnson and Grafton 2003;Johnson-Frey et al 2005). Viewing or naming of tools without motor execution also activates the left PPC, mainly in the IPL, and premotor cortex, together with the regions representing specific object categories in the temporal cortex (Chao et al 1999;Chao and Martin 2000;Noppeney et al 2006;Mahon et al 2007;Mruczek et al 2013;Peeters et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Ogawa

Imai

2016

Exp Brain Res

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Previous neuropsychological studies of ideomotor apraxia (IMA) indicated impairments in pantomime actions for tool use for both right and left hands following lesions of parieto-premotor cortices in the left hemisphere. Using functional magnetic resonance imaging (fMRI) with multi-voxel pattern analysis (MVPA), we tested the hypothesis that 5 the left parieto-premotor cortices are involved in the storage or retrieval of hand-independent representation of tool use actions. In the fMRI scanner, one of three kinds of tools was displayed in pictures or letters, and the participants made pantomimes of the use of these tools using the right hand for the picture stimuli or with the left hand for the letters. We then used MVPA to classify which kind of tool the subjects were pantomiming. 10Whole-brain searchlight analysis revealed successful decoding using the activities largely in the contralateral primary sensorimotor region, ipsilateral cerebellum, and bilateral early visual area, which may reflect differences in low-level sensorimotor components for three types of pantomimes. Furthermore, a successful cross-classification between the right and left hands was possible using the activities of the left inferior parietal lobule (IPL) near the 15 junction of the anterior intraparietal sulcus. Our finding indicates that the left anterior intraparietal cortex plays an important role in the production of tool-use pantomimes in a hand-independent manner, and independent of stimuli modality.

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Section: Discussionmentioning

confidence: 99%

Section: Iplmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Ogawa

Imai

2016

Exp Brain Res

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“…Naming [Grafton et al, 1997;Martin et al, 1996] or recognition [Grafton et al, 1997;Perani et al, 1995] of man-made tools similarly activates left frontal regions. Finally, strongly left-sided activations in frontal areas are observed in two studies in which tool-use gestures are compared with simple movements during real or imagined pantomimes upon verbal command [Choi et al, 2001;Moll et al, 2000].…”

Section: Action Semantic Systemmentioning

confidence: 92%

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Peigneux

Linden

Garraux

et al. 2004

Human Brain Mapping

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Abstract:The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychological model for upper limb apraxia [Rothi LJ, et al. The Neuropsychology of Action. 1997. Hove, UK: Psychology Press]. Regional cerebral blood flow was measured in healthy volunteers using H 2 15O PET during performance of four tasks commonly used for testing upper limb apraxia, i.e., pantomime of familiar gestures on verbal command, imitation of familiar gestures, imitation of novel gestures, and an action-semantic task that consisted in matching objects for functional use. We also re-analysed data from a previous PET study in which we investigated the neural basis of the visual analysis of gestures. First, we found that two sets of discrete brain areas are predominantly engaged in the imitation of familiar and novel gestures, respectively. Segregated brain activation for novel gesture imitation concur with neuropsychological reports to support the hypothesis that knowledge about the organization of the human body mediates the transition from visual perception to motor execution when imitating novel gestures [Goldenberg Neuropsychologia 1995;33:63-72]. Second, conjunction analyses revealed distinctive neural bases for most of the gesture-specific cognitive processes proposed in this cognitive model of upper limb apraxia. However, a functional analysis of brain imaging data suggested that one single memory store may be used for "to-be-perceived" and "to-be-produced" gestural representations, departing from Rothi et al.'s proposal. Based on the above considerations, we suggest and discuss a revised model for upper limb apraxia that might best account for both brain imaging findings and neuropsychological dissociations reported in the apraxia literature.

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“…Based on dissociations in brain-damaged patients, Goodale and Milner (1992) and Milner and Goodale (1995) suggested that pantomime was more dependent on the ventral stream of visual processing (temporal lobe "what" pathway) and less dependent on the dorsal stream (parietal lobe "where and how" pathway) than object use. However, one fMRI suggested that parietal cortex is critical for pantomimed tool use, as the primary difference between pantomiming and reproducing a meaningless gesture sequence was in parietal rather than temporal regions (Moll et al, 2000). Not in dispute is the fact that, in both healthy subjects and patients, the actions performed during pantomimed and real-object use are not identical (Goodale et al, 1994;Laimgruber et al, 2004;Milner and Goodale, 1995;Westwood et al, 2000).…”

Section: Varieties Of Action: Pantomime Versus Interactions With Realmentioning

confidence: 99%

Memory for pantomimed actions versus actions with real objects

Senkfor

2008

Cortex

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A substantial literature indicates that human actions during object use and pantomimed object use are not identical, and can be differentially affected by brain damage such that apraxic patients can be more impaired in performing actions with objects or at pantomiming such actions. A different literature suggests that memory retrieval can involve reinstating or recapitulating some of the same brain activity that occurred during the original event. The current experiment examines memory for pantomimed actions versus those conducted with real objects to determine if accuracy or brain electrical activity differs during the recollection of episodes involving pantomime versus actual object use. Across two sessions, participants were presented with images of studied objects and judged whether each object was studied by (1) performing an action, (2) watching the experimenter perform an action, (3) imagining an action, or (4) the nonmotoric control task of estimating the object's cost. The study phases preceding this source memory test differed across sessions: in one, participants were presented with real objects and estimated its cost or performed, watched, or imagined typical actions with the objects; in the other they viewed images of each object and estimated its cost or performed, imagined, or watched pantomimes of object use. Although source accuracy was the same across sessions, event-related potentials (ERPs) recorded during memory retrieval differed for memory for actions with real objects versus their pantomime equivalents. Retrieval-phase activity did not differ for cost-encoded objects. The real-object/pantomime difference in brain activity was maximal over left frontal and frontocentral cortex, suggesting differential engagement of motor cortex during memory for real actions versus pantomimed actions.

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Functional MRI correlates of real and imagined tool-use pantomimes

Cited by 157 publications

References 18 publications

Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Memory for pantomimed actions versus actions with real objects

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