Functional MR Imaging during Hypercapnia and Hyperoxia: Noninvasive Tool for Monitoring Changes in Liver Perfusion and Hemodynamics in a Rat Model<sup>1</sup>

Barash, Hila; Gross, Eitan; Matot, Idit; Edrei, Yifat; Tsarfaty, Galia; Spira, Gad; Vlodavsky, Israël; Galun, Eithan; Abramovitch, Rinat

doi:10.1148/radiol.2433060433

Cited by 37 publications

(61 citation statements)

References 29 publications

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“…25 In this study, in control mice PHx was followed by a decrease in both ⌬Sco 2 and ⌬So 2 , reflecting a decrease in liver vascularity and blood content. In contrast, in the livers of Casp8 F/Ϫ :Alb-Cre mice, 4 days after PHx both parameters increased (Fig.…”

Section: Caspase-8 Deletion In Hepatocytes Compromisesmentioning

confidence: 45%

Role of caspase-8 in hepatocyte response to infection and injury in mice

Moshe

Barash²,

Kang

et al. 2007

Hepatology

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Caspase-8 has been implicated in signaling for apoptotic cell death and for certain nonapoptotic functions. However, knowledge of actual physiological or pathophysiological processes to which this enzyme contributes is lacking. Using a mouse model and employing the conditional knockout approach to delete the caspase-8 gene specifically in the liver, we found that caspase-8 deficiency in hepatocytes facilitates infection of the liver by Listeria monocytogenes, attenuates the hepatocyte proliferation wave during the first 48 hours after partial hepatectomy and, depending on the genetic background of the mice, prompts a chronic inflammatory response to the hepatectomy, as a result of which the proliferation of hepatocytes, although initially suppressed, might later be persistently enhanced, resulting in significant hepatomegaly. Conclusion: These findings indicate that caspase-8 participates in regulation of the cellular response to infection and injury and that it does so by affecting various cellular functions, including cell death, cell proliferation, and induction of inflammation. (HEPATOLOGY 2007;45:1014-1024

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Section: Caspase-8 Deletion In Hepatocytes Compromisesmentioning

confidence: 45%

Role of caspase-8 in hepatocyte response to infection and injury in mice

Moshe

Barash²,

Kang

et al. 2007

Hepatology

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“…Changes in hepatic hemodynamics were evaluated using T * 2 -weighted GRE (TR/TE=147/10ms). The images were acquired following the protocol in [2] and co-registered since the mice are fixed and immobilized under anesthesia. When metastases became large (18 days after tumor cells injection, and above), the mice were sacrificed, and their livers were taken for histology.…”

Section: Resultsmentioning

confidence: 99%

“…The fMRI images are acquired during the breathing of air, air-carbon dioxide (5% CO 2 ), and carbogen (95% oxygen; 5% CO 2 ) according to the protocol in [2], and co-registered.…”

Section: Methodsmentioning

confidence: 99%

“…Barash et al [2] have recently demonstrated the utility of functional Magnetic Resonance Imaging (fMRI) with hypercapnia and hyperoxia for monitoring changes in liver perfusion and hemodynamics without contrast agent administration. Based on these findings, Edrei et al [3] showed how to characterize colorectal hepatic metastases and how to follow their early hemodynamical changes.…”

Section: Introductionmentioning

confidence: 99%

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Classification of Suspected Liver Metastases Using fMRI Images: A Machine Learning Approach

Freiman

Edrei

Sela

et al. 2008

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008

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Abstract. This paper presents a machine-learning approach to the interactive classification of suspected liver metastases in fMRI images. The method uses fMRI-based statistical modeling to characterize colorectal hepatic metastases and follow their early hemodynamical changes. Changes in hepatic hemodynamics are evaluated from T * 2 -W fMRI images acquired during the breathing of air, air-CO2, and carbogen. A classification model is build to differentiate between tumors and healthy liver tissues. To validate our method, a model was built from 29 mice datasets, and used to classify suspicious regions in 16 new datasets of healthy subjects or subjects with metastases in earlier growth phases. Our experimental results on mice yielded an accuracy of 78% with high precision (88%). This suggests that the method can provide a useful aid for early detection of liver metastases.

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“…We have recently demonstrated the sensitivity of hemodynamic response imaging (HRI), a functional BOLD MRI, where transient alterations in inspired gases from normoxia to hypercapnia and subsequently to hyperoxia enable the evaluation of renal oxygenation, perfusion and vascular reactivity without the need for injected contrast agents [14]. This method, first applied in hepatic imaging [15], has been found particularly applicable in the kidney, where altered vascular reactivity may be both a hallmark for and a causative parameter in the pathogenesis of renal impairment.…”

Section: Introductionmentioning

confidence: 99%

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

Milman

Axelrod²,

Heyman³

et al. 2014

Am J Nephrol

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Background/Aims: Changes in renal oxygenation and perfusion have been identified as common pathways to the development and progression of renal disease. Recently, the sensitivity of hemodynamic response imaging (HRI) was demonstrated; this is a functional magnetic resonance imaging (MRI) method combined with transient hypercapnia and hyperoxia for the evaluation of renal perfusion and vascular reactivity. The aim of this study was to utilize HRI for the noninvasive evaluation of changes in renal hemodynamics and morphology during acute, chronic and acute-on-chronic renal failures. Methods: Renal-HRI maps and true fast imaging with steady-state precession (True-FISP) images were used to evaluate renal perfusion, morphology and corticomedullary differentiation (CMD). MR images were acquired on two mouse models of kidney injury: adenine-induced chronic kidney disease (CKD) and rhabdomyolysis-induced acute kidney injury (AKI). Serum urea was measured from these mice in order to determine renal function. Results: Renal-HRI maps revealed a blunted response to hypercapnia and hyperoxia with evolving kidney dysfunction in both models, reflecting hampered renal vascular reactivity and perfusion. True-FISP images showed a high sensitivity to renal morphological changes, with different patterns characterizing each model. Calculated data obtained from HRI and True-FISP during the evolution of renal failure and upon recovery, with and without protective intervention, closely correlated with the degree of renal impairment. Conclusions: This study suggests the potential combined usage of two noninvasive MRI methods, HRI and True-FISP, for the assessment of renal dysfunction without the potential risk associated with contrast-agents administration. HRI may also serve as a research tool in experimental settings, revealing the hemodynamic changes associated with kidney dysfunction.

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Functional MR Imaging during Hypercapnia and Hyperoxia: Noninvasive Tool for Monitoring Changes in Liver Perfusion and Hemodynamics in a Rat Model¹

Cited by 37 publications

References 29 publications

Role of caspase-8 in hepatocyte response to infection and injury in mice

Role of caspase-8 in hepatocyte response to infection and injury in mice

Classification of Suspected Liver Metastases Using fMRI Images: A Machine Learning Approach

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

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Functional MR Imaging during Hypercapnia and Hyperoxia: Noninvasive Tool for Monitoring Changes in Liver Perfusion and Hemodynamics in a Rat Model1

Cited by 37 publications

References 29 publications

Role of caspase-8 in hepatocyte response to infection and injury in mice

Role of caspase-8 in hepatocyte response to infection and injury in mice

Classification of Suspected Liver Metastases Using fMRI Images: A Machine Learning Approach

Assessment with Unenhanced MRI Techniques of Renal Morphology and Hemodynamic Changes during Acute Kidney Injury and Chronic Kidney Disease in Mice

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Functional MR Imaging during Hypercapnia and Hyperoxia: Noninvasive Tool for Monitoring Changes in Liver Perfusion and Hemodynamics in a Rat Model¹