Functional MR evaluation of temporal and frontal language dominance compared with the Wada test

Lehericy, Stéphane; Cohen, Laurent; Bazin, B.; Samson, Séverine; Giacomini, Eric; Rougetet, R.; Hertz-Pannier, Lucie; Bihan, Denis Le; Marsault, C.; Baulac, Michel

doi:10.1212/wnl.54.8.1625

Cited by 397 publications

(259 citation statements)

References 39 publications

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“…Reanalysing the study by Adcock et al (2003) shows that there are no differences in terms of LI values between pre-operative LTL and RTL patients when only patients with a lefthemispheric language dominance according to the IAP were selected. Because of the pre-operative language lateralization criterion and the almost perfect agreement between fMRI and IAP language lateralization reported in many studies (Binder et al, 1996;Yetkin et al, 1998;Lehéricy et al, 2000;Rutten et al, 2002a,b;Spreer et al, 2002;Adcock et al, 2003;Woermann et al, 2003) for RTL and LTL patients, the interhemispheric redistributions effects found in this study are more likely to occur due to the surgical intervention. Post-operative cerebral changes would moreover explain the rather large number of patients exhibiting disagreement between IAP and post-operative fMRI results as found in this study.…”

Section: Discussionsupporting

confidence: 72%

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Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

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Objective: To reveal differences of cerebral activation related to language functions in post-operative temporal lobe epilepsy (TLE) patients. Methods: Right (RTL) and left temporal lobe (LTL) resected patients, and healthy controls were studied using functional magnetic resonance imaging (fMRI). Only patients with complete left-hemispheric language dominance according to the intracarotid amytal procedure (IAP) were included. Language-related activations were evoked by performing word generation and text reading language tasks. Activation lateralization and temporo-frontal distribution effects were analysed. Results: For word generation, only LTL patients showed reduced left lateralized activation compared to controls, due to a decrease in activation in the left prefrontal cortex and an increase in the right prefrontal cortex. For reading, the left-hemispheric lateralization in RTL patients increased because of enhanced activity in the left prefrontal cortex, whereas for LTL patients the activation became bilaterally distributed over the temporal lobes. Lateralization results between pre-operative IAP and postoperative fMRI were highly discordant. Significant temporo-frontal distribution changes manifested from the reading but not from the word generation task. * Corresponding author. Backes et al. / Epilepsy Research 66 (2005) [1][2][3][4][5][6][7][8][9][10][11][12] Conclusion: The cerebral language representation in post-operative LTL epilepsy patients is more bi-hemispherically lateralized than in controls and RTL patients. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologuous brain areas, are suggested to contribute to the cerebral reorganisation of language function.

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Section: Discussionsupporting

confidence: 72%

“…Until now, extremely good correlations have been published between fMRI and the IAP, especially for epilepsy patients with a typical (i.e. left dominant) language representation (Binder et al, 1996;Yetkin et al, 1998;Lehéricy et al, 2000;Rutten et al, 2002a,b;Spreer et al, 2002;Adcock et al, 2003;Woermann et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

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“…To date, most of this literature has focused on cerebral activations associated with semantic decisions, silent word generation, covert repetition, and covert naming in controls and patients with TLE (for a comprehensive review, see (45)). These studies have demonstrated prominent activations in left prefrontal areas (45,65-67), with less consistent activations in temporoparietal regions (65). Such data have led some experts to conclude that fMRI may be better suited for localizing expressive language areas within the frontal lobe than receptive language areas within temporal lobe regions ((68,69), but see (70,71)).…”

Section: Fmrimentioning

confidence: 99%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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“…In recent years, several studies have compared fMRI and the IAP with respect to language lateralization, or evaluated the ability of fMRI to localize language functions in children and adults with epilepsy [12][13][14][15][16][17][18][19][20][21][22][23][24]. These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31].…”

Section: Introductionmentioning

confidence: 99%

“…These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31]. Some studies have also reported the use of more than one fMRI paradigm for language localization and lateralization [10,12,13,29,32,33], but the results of these studies have been mixed, with some tasks showing good and some poor correlation with the results of IAP.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

112

137

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Functional magnetic resonance imaging (fMRI) has the potential to replace the intracarotid amobarbital procedure (IAP) in presurgical evaluation of patients with epilepsy patients. In this study, we compared fMRI verb generation (VG) and semantic decision/tone decision (SDTD) tasks and the IAP in their ability to localize language functions in patients with epilepsy undergoing presurgical evaluation. We enrolled 50 healthy controls to establish normal language activation patterns for VG and SDTD tasks at 3 or 4 T, and to design language regions of interest (ROIs) that were later applied to 38 patients with epilepsy (28 of 38 also underwent the IAP). We calculated laterality indices (LIs) for each task for each subject based on the ROIs, and we used general linear modeling to analyze the fMRI data. All healthy and epileptic subjects activated language areas with both fMRI tasks. We found significant correlations in language lateralization between the fMRI tasks (r = 0.495, P ≤ 0.001) and between VG and IAP (r = 0.652, P < 0.001) and SDTD and IAP (r = 0.735, P < 0.001). The differences in LIs between SDTD and VG tasks were small and not affected by age, gender, epilepsy status, handedness, or performance. SDTD and VG tasks combined explained approximately 58.4% in the variability of the IAP/language. In the general linear modeling, only the SDTD task significantly contributed to the determination of language lateralization in patients with epilepsy undergoing presurgical evaluation. Results indicate a moderate convergent validity between both fMRI language tasks and between IAP and fMRI tasks. The results of this study indicate that either of these fMRI tasks can be used for language lateralization in patients with epilepsy undergoing presurgical evaluation, but that the SDTD task is likely to provide more information regarding language lateralization than the VG task.

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Functional MR evaluation of temporal and frontal language dominance compared with the Wada test

Cited by 397 publications

References 39 publications

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

The use of neuroimaging to study behavior in patients with epilepsy

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

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