1992
DOI: 10.1159/000276294
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Functional Morphology of the Human Endolymphatic Sac

Abstract: Modern immunohistochemical methods allow a functional characterization of the human endolymphatic sac (ES) and its associated cell populations. The currently available immunohistochemical data on the extraosseous part of the human ES support the assumption that the epithelium is metabolically active and capable of both secretion and absorption. The reactivity of some epithelial cells with antibodies against neuroendocrine antigens implies a paracrine activity of the human ES. Further results provide evidence f… Show more

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Cited by 10 publications
(5 citation statements)
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“…The presence of immunoglobulin A (IgA), secretory components like Cytokeratins 18 and 19, vimentins, as well as the J chain, was described within epithelial cells and in the lumen of the human ES. 19,20 Thus, the expression of these substances in the human ES epithelium supports the assumption that the ES is metabolically active and functionally related to a mesothelium that has both secretory, resorptive, and elimination capabilities 10,19,20 A positive reaction for neuron-specific enolase and neurosecretory antigens was demonstrated in a few epithelial cells of the rugose part of the human ES. 19,20 In addition, neurosecretory granules and somatostatin were observed in cells of the human ES.…”
Section: Secretion Of Substancessupporting
confidence: 67%
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“…The presence of immunoglobulin A (IgA), secretory components like Cytokeratins 18 and 19, vimentins, as well as the J chain, was described within epithelial cells and in the lumen of the human ES. 19,20 Thus, the expression of these substances in the human ES epithelium supports the assumption that the ES is metabolically active and functionally related to a mesothelium that has both secretory, resorptive, and elimination capabilities 10,19,20 A positive reaction for neuron-specific enolase and neurosecretory antigens was demonstrated in a few epithelial cells of the rugose part of the human ES. 19,20 In addition, neurosecretory granules and somatostatin were observed in cells of the human ES.…”
Section: Secretion Of Substancessupporting
confidence: 67%
“…19,20 In addition, neurosecretory granules and somatostatin were observed in cells of the human ES. 10,19,20 All this information contributes to the hypotheses of the secretory capacity of the ES.…”
Section: Secretion Of Substancesmentioning
confidence: 94%
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“…В то время как основные функции эндолимфатического мешка связаны с регулированием объема и давления эндолимфатической жидкости, а также удалением из нее продуктов жизнедеятельности посредством гетерофагии, в последнее время рассматривается также и его эндокринная/паракринная функция. Различные нарушения гомеостаза эндолимфатического мешка связывают с развитием болезни Меньера [1][2][3].…”
unclassified
“…[3][4][5][6][7] The sac continues to undergo considerable change in the late fetal and postnatal periods.O Most of the internal ear becomes encased in the bony otic capsule shortly after midterm.s The endolymphatic sac, which is the terminal saccular enlargement of the endolymphatic duct, lies between the inner and outer layers ofthe dura and the posterior surface of the petrous portion of the temporal bone, where it can expand with the growing dura.f At all ages the sac is leaflike, with its proximal part connecting to the endolymphatic duct much as a leaf is attached to its stem.s Three regions of the sac are commonly recognized: the proximal or rugose region, the sac proper, and the distal projection. The sac and duct are embryologically derived from neuroectodermal stem cells of the otocyst and differentiate morphologically and functionally throughout gestation.…”
mentioning
confidence: 99%