Functional molecular electronic devices through environmental control

Su, Dingkai; Gu, Chunhui; Guo, Xuefeng

doi:10.1007/s40843-018-9301-3

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…Among single-molecule techniques (16,17), graphenemolecule-graphene single-molecule junctions (GMG-SMJs) are particularly useful because they have the unique ability of covalently incorporating individual molecular systems behaving as the conductive channel into an electrical nanocircuit, which solves the challenges of the fabrication difficulty and poor device stability. This approach has proven to be a robust platform of single-molecule electronics that is capable of creating molecular optoelectronic devices (18)(19)(20)(21) and probing the dynamic processes of submolecular changes at the single-event level with high temporal resolution and high signal-to-noise ratios (22), for example, carbon cation formation (23), photoinduced conformational transition (24), nucleophilic addition (25), and cocaine detection (26).…”

Section: Introductionmentioning

confidence: 99%

A single-molecule electrical approach for amino acid detection and chirality recognition

Liu

Masai

et al. 2021

Sci. Adv.

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One of the ultimate goals of analytic chemistry is to efficiently discriminate between amino acids. Here we demonstrate this ability using a single-molecule electrical methodology based on molecular nanocircuits formed from stable graphene-molecule-graphene single-molecule junctions. These molecular junctions are fabricated by covalently bonding a molecular machine featuring a permethylated-β-cyclodextrin between a pair of graphene point contacts. Using pH to vary the type and charge of the amino acids, we find distinct multimodal current fluctuations originating from the different host-guest interactions, consistent with theoretical calculations. These conductance data produce characteristic dwell times and shuttling rates for each amino acid, and allow accurate, statistical real-time, in situ measurements. Testing four amino acids and their enantiomers shows the ability to distinguish between them within a few microseconds, thus paving a facile and precise way to amino acid identification and even single-molecule protein sequencing.

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Section: Introductionmentioning

confidence: 99%

A single-molecule electrical approach for amino acid detection and chirality recognition

Liu

Masai

et al. 2021

Sci. Adv.

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“…35−38 Environmental control is an effective method to regulate the electronic state and the molecule−electrode interface, greatly enriching the responsible functions of molecular electronic devices. 39 The molecular orbitals can be tuned by humidity, 40 light, 28,41−43 chemical substance, 44 electrochemical (ionic) environment, 25 and postmodification (chemical treatment). 45 Ai and Chiechi et al recently reported a reversible interconversion of molecular tunneling junctions comprising carboxylic acid-terminated SAMs between diodes and resistors.…”

Section: Introductionmentioning

confidence: 99%

“…Environmental control is an effective method to regulate the electronic state and the molecule–electrode interface, greatly enriching the responsible functions of molecular electronic devices . The molecular orbitals can be tuned by humidity, light, ,− chemical substance, electrochemical (ionic) environment, and postmodification (chemical treatment) .…”

Section: Introductionmentioning

confidence: 99%

Modulated Rectification of Carboxylate-Terminated Self-Assembled Monolayer Junction by Humidity and Alkali Metal Ions: The Coupling and Asymmetric Factor Matter

Tian

Song

et al. 2021

J. Phys. Chem. C

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Facile modulation of the rectification behavior of a molecular junction device was achieved by humidity and alkali metal ions using a series of carboxylic acid-terminated self-assembled monolayers (COOH SAMs) on gold and eutectic gallium-indium alloy top contact (EGaIn). The rectification ratio (RR) increased significantly as the humidity (ranging from 1 to 39%) increases for an n-mercaptoalkanoic acid (HSC n O2H, n = 11, 12, 14, 16) SAM device. Meanwhile, K+/Na+, as the counterion of COO– in the same element group with H+, enhanced the RR of the SAM device as well. By the detailed study of the rectifying current–voltage (I–V) response using a theoretical model based on single-level tunneling, we found that the modulated rectification behavior of SAMs was attributed to the change in the coupling strength of the carboxylic group with the EGaIn electrode and the asymmetry factor of the junction in the presence of water and K+/Na+. Our study here suggested that the delicate electronic structure change at the molecule–(GaO x )GaIn interface played the most significant role in the modulation of the rectification performance of the SAM device. The molecule–(GaO x )GaIn interface thus offered a great research opportunity to achieve the desired function of SAM-GaIn-based molecular devices.

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“…Biosensors, as an alternative and reliable solution for the analysis of biomolecules, has been drawing considerable research interest [14][15][16][17]. Among different kinds of optical and electrical biosensing technologies currently avalaible, field-effect transisitor (FET)-based biosensors are particularly attractive because of their remarkable features, including no fluorescent labeling requirement, highly sensitive detection, mass-production capability and low cost.…”

Section: Introductionmentioning

confidence: 99%

An accurate, high-speed, portable bifunctional electrical detector for COVID-19

Liu

et al. 2020

Sci. China Mater.

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Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread and caused a severe global pandemic. Because no specific drugs are available for COVID-19 and few vaccines are available for SARS-CoV-2, accurate and rapid diagnosis of COVID-19 has been the most crucial measure to control this pandemic. Here, we developed a portable bifunctional electrical detector based on graphene fieldeffect transistors for SARS-CoV-2 through either nucleic acid hybridization or antigen-antibody protein interaction, with ultra-low limits of detection of ~0.1 and ~1 fg mL −1 in phosphate buffer saline, respectively. We validated our method by assessment of RNA extracts from the oropharyngeal swabs of ten COVID-19 patients and eight healthy subjects, and the IgM/IgG antibodies from serum specimens of six COVID-19 patients and three healthy subjects. Here we show that the diagnostic results are in excellent agreement with the findings of polymerase chain reaction-based optical methods; they also exhibit rapid detection speed (~10 min for nucleic acid detection and ~5 min for immunoassay). Therefore, our assay provides an efficient, accurate tool for high-throughput point-of-care testing. Electronic Supplementary Material Supplementary material is available in the online version of this article at 10.1007/s40843-020-1577-y.

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Functional molecular electronic devices through environmental control

Cited by 7 publications

References 33 publications

A single-molecule electrical approach for amino acid detection and chirality recognition

A single-molecule electrical approach for amino acid detection and chirality recognition

Modulated Rectification of Carboxylate-Terminated Self-Assembled Monolayer Junction by Humidity and Alkali Metal Ions: The Coupling and Asymmetric Factor Matter

An accurate, high-speed, portable bifunctional electrical detector for COVID-19

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