Functional mimicry of sea urchin biomineralization proteins with CaCO₃-binding peptides selected by phage display

Abstract

The study demonstrates how bioinspired peptides, selected via phage display, mimic sea urchin proteins, influencing the formation of CaCO3 crystals. Charged peptides play a crucial role in shaping these crystals.

Effect of Magnesium and Ferric Ions on the Biomineralization of Calcium Carbonate Induced by Synechocystis sp. PCC 6803

“…Proteins have the ability to modify the spatial orientation, morphology, and mineral phase of crystals [80]. Certain peptides that bind to CaCO 3 induce similar morphological characteristics in calcite as those observed when natural protein mixes were present [81]. These processes are regulated by distinct proteins, each exhibiting its own unique secondary structure and undergoing conformational changes [80].…”