Functional micro-RNA drugs acting as a fate manipulator in the regulation of osteoblastic death

Cai, Zhengwen; Liu, Fengshuo; Li, Yong; Bai, Linquan; Feng, Maogeng; Li, Songhang; Ma, Wenjuan; Shi, Sirong

doi:10.1039/d3nr02318d

Cited by 5 publications

(2 citation statements)

References 145 publications

(211 reference statements)

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“…MiR-21 variation in pro-osteoclastogenesis is consistent with the upregulation of circulating miR-21 during ONJ progression [29,30]. The primary targets of miR-145 instead include interleukin (IL) and genes related to bone homeostasis, such as osteomodulin, cwcv, and kazal-like domains proteoglycan 2, SPARC/osteonectin, and secreted protein acidic and rich in cysteine [6,31,32]. Additionally, miR-21 showed a favorable link with the pathophysiology of particle-induced osteolysis, and its knockdown-restricted osteoclastogenesis.…”

Section: Mirnasmentioning

confidence: 66%

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Caserta,

Stagno,

Gangemi

et al. 2024

IJMS

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Osteonecrosis of the jaw is the progressive loss and destruction of bone affecting the maxilla or mandible in patients treated with antiresorptive and antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves the inflammatory pathway of receptor activator of nuclear factor NF-kB ligand and the macrophage colony-stimulating factor, essential for osteoclast precursors survival and proliferation and acting through its receptor c-Fms. Evidence has shown the role of non-coding RNAs in the pathogenesis of osteonecrosis of the jaw and this finding might be useful in diagnosis since these small RNAs could be considered as biomarkers of apoptotic activity in bone. Interestingly, it has been proved that miR-29 and miR-31-5p, acting on specific targets such as CALCR and RhoA, promote programmed-cell death and consequently the necrosis of bone tissue. Specific long non-coding RNAs, instead, have been detected both at reduced levels in patients with multiple myeloma and osteonecrosis, and associated with suppression of osteoblast differentiation, with consequences in the progression of mandible lesions. Among non-coding genic material, circular RNAs have the capability to modify the expression of specific mRNAs responsible for the inhibition of bisphosphonates activity on osteoclastogenesis.

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Section: Mirnasmentioning

confidence: 66%

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Caserta,

Stagno,

Gangemi

et al. 2024

IJMS

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“…It is characterized membrane rupture by activating NLRP3/Caspase-1/GSDMD signaling, causing the excessive release of pro-inflammatory cytokines, mainly included IL-18 and IL-1β ( Shi, et al, 2015 ). Many research has reported that pyroptosis plays an important role in occurrence and development of osteoporosis ( Cai, et al, 2023 ; Fu, et al, 2023 ; Tao, et al, 2020b ). Osteoblasts are the main functional cells in bone formation, responsible for the synthesis, secretion and mineralization of bone matrix, which also plays an essential role in formation of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Melatonin prevents cadmium-induced osteoporosis by affecting the osteoblast and osteoclast differentiation and pyroptosis in duck

Ma,

Su,

Zhao

et al. 2024

Poultry Science

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DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis

Qi,

Hong,

Zhao

et al. 2024

Adv Healthcare Materials

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Compromised osteogenesis and angiogenesis is the character of stem cell senescence, which brought difficulties for bone defects repairing in senescent microenvironment. As the most abundant bone‐related miRNA, miRNA‐21‐5p plays a crucial role in inducing osteogenic and angiogenic differentiation. However, highly efficient miR‐21‐5p delivery still confronts challenges including poor cellular uptake and easy degradation. Herein, TDN‐miR‐21‐5p nanocomplex is constructed based on DNA tetrahedral (TDN) and has great potential in promoting osteogenesis and alleviating senescence of senescent bone marrow stem cells (O‐BMSCs), simultaneously enhancing angiogenic capacity of senescent endothelial progenitor cells (O‐EPCs). Of note, the activation of AKT and Erk signaling pathway may direct regulatory mechanism of TDN‐miR‐21‐5p mediated osteogenesis and senescence of O‐BMSCs. Also, TDN‐miR‐21‐5p can indirectly mediate osteogenesis and senescence of O‐BMSCs through pro‐angiogenic growth factors secreted from O‐EPCs. In addition, gelatin methacryloyl (GelMA) hydrogels are mixed with TDN and TDN‐miR‐21‐5p to fabricate delivery scaffolds. TDN‐miR‐21‐5p@GelMA scaffold exhibits greater bone repair with increased expression of osteogenic‐ and angiogenic‐related markers in senescent critical‐size cranial defects in vivo. Collectively, TDN‐miR‐21‐5p can alleviate senescence and induce osteogenesis and angiogenesis in senescent microenvironment, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs‐based gene therapy.

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Functional micro-RNA drugs acting as a fate manipulator in the regulation of osteoblastic death

Abstract: Osteoblastic death can be regulated by miRNAs. We propose a tetrahedral DNA nanostructure-based microRNA delivery system (Tmi) as an example of miRNA drugs application, which provides a new strategy for gene therapy in bone diseases.

Cited by 5 publications

References 145 publications

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Melatonin prevents cadmium-induced osteoporosis by affecting the osteoblast and osteoclast differentiation and pyroptosis in duck

DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis

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