Functional MICA Variants Are Differentially Associated with Immune-Mediated Inflammatory Diseases
Chin-Man Wang,
Keng-Poo Tan,
Yeong-Jian Jan Wu
et al.
Abstract:As the principal ligand for NKG2D, MICA elicits the recruitment of subsets of T cells and NK cells in innate immunity. MICA gene variants greatly impact the functionality and expression of MICA in humans. The current study evaluated whether MICA polymorphisms distinctively influence the pathogenesis of psoriasis (PSO), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) in Taiwanese subjects. The distributions of MICA alleles and levels of serum soluble NKG2D were compared between healthy control… Show more
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