Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds

Wang, Tianyu; Liu, Jingjing; Luo, Xialin; Hu, Longlong; Lü, Haitao

doi:10.1016/j.pharmthera.2021.107824

Cited by 39 publications

(19 citation statements)

References 126 publications

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“…To clarify the mechanism of TCM, it is necessary to study the pathways and targets of each active ingredient alone and in different combinations. It is also necessary to find a suitable breakthrough point and establish a reasonable pharmacological model based on genomics, proteomics, functional metabolomics, TCM pharmacology, and other -omics research ( Han Y et al, 2020 ; Ma et al, 2020 ; Wang T et al, 2021 ). Determining the mechanism of the effective ingredients can not only explain how the various ingredients in TCM work individually or in combination, but also, and more importantly, it can discover new mechanisms and synergistic effects of the effective ingredients, which is conducive to innovation of TCM and the development of TCM theories.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

et al. 2022

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Heart failure (HF) is one of the main public health problems at present. Although some breakthroughs have been made in the treatment of HF, the mortality rate remains very high. However, we should also pay attention to improving the quality of life of patients with HF. Traditional Chinese medicine (TCM) has a long history of being used to treat HF. To demonstrate the clinical effects and mechanisms of TCM, we searched published clinical trial studies and basic studies. The search results showed that adjuvant therapy with TCM might benefit patients with HF, and its mechanism may be related to microvascular circulation, myocardial energy metabolism, oxidative stress, and inflammation.

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Section: Discussionmentioning

confidence: 99%

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

et al. 2022

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“…A. cochinchinensis has a long history of ethnopharmacological use and is characterized by bitter in taste and cold in nature. Since ancient times, researchers continuously explore and exploited TCM practices ( Zhang X. et al, 2021 ; Wang et al, 2021 ). Dating back more than 1700 years of history, A. cochinchinensis was first documented in Shennong’s Classic of Materia Medica (Dong Han Dynasty, 25–220 A.D.), which is the earliest classic on TCM.…”

Section: Traditional Usesmentioning

confidence: 99%

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Wang

et al. 2022

Front. Pharmacol.

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Asparagus cochinchinensis (Lour.) Merr. (A. cochinchinensis) is a traditional herbal medicine that is used to treat constipation, fever, pneumonia, stomachache, tracheitis, rhinitis, cataract, acne, urticaria. More than 90 compounds have been identified from different structural types in A. cochinchinensis, including steroidal saponins, C21-steroides, lignans, polysaccharides, amino acids, etc. These bioactive ingredients make A. cochinchinensis remarkable for its pharmacological effects on anti-asthma, anti-inflammatory, anti-oxidation, anti-tumor, improving Alzheimer’s disease, neuroprotection, gut health-promoting and so on. Moreover, A. cochinchinensis also plays an important role in food, health product, cosmetic, and other fields. This review focused on the research publications of A. cochinchinensis and aimed to summarize the advances in the botany, traditional uses, phytochemistry, pharmacology, and applications which will provide reference for the further studies and applications of A. cochinchinensis.

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“…Since TCM is considered as a mixture of multiple chemical compounds and often targets multiple proteins and pathways, its mechanism is difficult to be explained by the modern medicine system. With the development of omics research, like genomics, proteomics and metabolomics, ways of combining bioinformatics analysis and medicinal experiments have become more and more popular and feasible to explore the obscure mechanism of TCM [ 15 ]. For example, the antimicrobial activity of epigallocatechin gallate from green tea against Streptococcus suis was analyzed by the synthesis of proteomics and TEM observation to infer a possible mechanism about cell wall and membrane damage [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Combining the In Silico and In Vitro Assays to Identify Strobilanthes cusia Kuntze Bioactives against Penicillin-Resistant Streptococcus pneumoniae

et al. 2023

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Leaves of Strobilanthes cusia Kuntze (S. cusia) are a widely used alexipharmic Traditional Chinese Medicine (TCM) in southern China for the prevention of cold and respiratory tract infectious diseases. One of the most common bacterial pathogens in the respiratory tract is the gram-positive bacterium Streptococcus pneumoniae. The antibiotic resistance of colonized S. pneumoniae makes it a more serious threat to public health. In this study, the leaves of S. cusia were found to perform antibacterial effects on the penicillin-resistant S. pneumoniae (PRSP). Confocal assay and Transmission Electron Microscopy (TEM) monitored the diminished cell wall integrity and capsule thickness of the PRSP with treatment. The following comparative proteomics analysis revealed that the glycometabolism-related pathways were enriched for the differentially expressed proteins between the samples with treatment and the control. To further delve into the specific single effective compound, the bio-active contents of leaves of S. cusia were analyzed by UPLC-UV-ESI-Q-TOF/MS, and 23 compounds were isolated for anti-PRSP screening. Among them, Tryptanthrin demonstrated the most promising effect, and it possibly inhibited the N-glycan degradation proteins, as suggested by reverse docking analysis in silico and further experimental verification by the surface plasmon resonance assay (SPR). Our study provided a research foundation for applications of the leaves of S. cusia as a TCM, and supplied a bio-active compound Tryptanthrin as a candidate drug skeleton for infectious diseases caused by the PRSP.

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Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds

Cited by 39 publications

References 126 publications

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Combining the In Silico and In Vitro Assays to Identify Strobilanthes cusia Kuntze Bioactives against Penicillin-Resistant Streptococcus pneumoniae

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