Functional mesoporous silica nanoparticles for delivering nimesulide with chiral recognition performance

Guo, Yingyu; Wu, Lulu; Gou, Kaijun; Wang, Yumei; Hu, Baichun; Pang, Yue; Li, Sanming; Li, Heran

doi:10.1016/j.micromeso.2019.109862

Cited by 19 publications

(14 citation statements)

References 40 publications

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“…Li et al successfully synthesized spherical CMS nanoparticles with concealed pore channels by grafting l -tartaric acid or d -tartaric acid, respectively [ 50 , 51 ]. Considering the defect of reducing pore space due to the grafting group, Guo et al designed enlarged pore CMS nanoparticles via the introduction of pore-enlarging agent 1,3,5-trimethylbenzene (TMB) while functional groups were grafted [ 52 , 53 ]. This provides more possibilities for further modification of CMS via grafting groups.…”

Section: Synthesis Of Chiral Mesoporous Silica (Cms) Nanoparticlesmentioning

confidence: 99%

“…In another work, Guo et al prepared two CMS at the molecular level by grafting l-/d- tartaric acid, namely FL MSNs and FD MSNs [ 52 ]. Apparently, nimesulide (NMS) loaded FD-MSNs and NMS loaded FL-MSNs displayed almost the same dissolution behaviour, but the cumulative release amounts were both much higher than that of pure NMS in PBS.…”

Section: Applications Of Chiral Mesoporous Silicamentioning

confidence: 99%

“…( B ) In vitro release profiles of NMS, NMS loaded FL-MSNs, and NMS loaded FD-MSNs in l -Ala-PBS or d -Ala-PBS. Credit: republished with permission of Elsevier, from Reference [ 52 ], Copyright (2020), permission conveyed through Copyright Clearance Center, Inc.…”

Section: Figurementioning

confidence: 99%

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Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and Applications

et al. 2020

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Because of its tunable textural properties and chirality feature, chiral mesoporous silica (CMS) gained significant consideration in many fields and has been developed rapidly in recent years. In this review, we provide an overview of synthesis strategies for fabricating CMS together with its main applications. The properties of CMS, including morphology and mesostructures and enantiomer excess (ee), can be altered according to the synthetic conditions during the synthesis process. Despite its primary stage, CMS has attracted extensive attention in many fields. In particular, CMS nanoparticles are widely used for enantioselective resolution and adsorption of chiral compounds with desirable separation capability. Also, CMS acts as a promising candidate for the effective delivery of chiral or achiral drugs to produce a chiral-responsive manner. Moreover, CMS also plays an important role in chromatographic separations and asymmetric catalysis. There has been an in-depth review of the synthetic methods and mechanisms of CMS. And this review aims to give a deep insight into the synthesis and application of CMS, especially in recent years, and highlights the significance that it may have in the future.

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Section: Synthesis Of Chiral Mesoporous Silica (Cms) Nanoparticlesmentioning

confidence: 99%

Section: Applications Of Chiral Mesoporous Silicamentioning

confidence: 99%

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Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and Applications

et al. 2020

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“…As an alternative, ordered mesoporous silica (OMS) materials with a high surface area, high stability, ready mass transport, and simple synthesis have gained extensive attention and been widely investigated in the fields of adsorption, , separation, and ion exchange . Particularly, a striking feature is that the OMS consists of tunable and modifiable nanochannels, which endows them with immense potential as candidates for enantioselective separation. , …”

Section: Introductionmentioning

confidence: 99%

“…16 Particularly, a striking feature is that the OMS consists of tunable and modifiable nanochannels, which endows them with immense potential as candidates for enantioselective separation. 17,18 Chiral OMS with open nanochannels may be synthesized according to the following approaches: (i) direct synthesis by using chiral templates 19,20 and (ii) post-modification of the achiral OMS with chiral molecules. 21−23 Compared with the former, the methods of post-modification are simple, inexpensive, and can maintain the order degree of nano-channels, 24 eventually, the choice of chiral selectors also plays a key role.…”

Section: ■ Introductionmentioning

confidence: 99%

Chiral Nanochannels of Ordered Mesoporous Silica Constructed by a Pillar[5]arene-Based Host–Guest System

Cheng

Zhu

et al. 2021

ACS Appl. Mater. Interfaces

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The separation of racemic compounds by chiral nanochannels has attracted extensive attention. However, the fabrication of high-performance chiral nanochannels is still a challenge owing to the difficulty in magnifying the weak chiral interaction to macroscopic properties of materials. Herein, by introducing a l-alanine-pillar[5]arene host to achiral ordered mesoporous silica (OMS), chiral OMS nanochannels were fabricated, which exhibited excellent selectivity (ee value up to 90.2%) to separate racemic drugs with promising reusability and stability. Besides, it was identified that enantioselective separation took place through a molecular-recognition-adsorbed transport mechanism. This work highlights the great potential of chiral OMS nanochannels as a platform for enantioselective separation.

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Polymeric Carbon Nitride with Chirality Inherited from Supramolecular Assemblies

et al. 2023

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The facile synthesis of chiral materials is of paramount importance for various applications. Supramolecular preorganization of monomers for thermal polymerization has been proven as an effective tool to synthesize carbon and carbon nitride‐based (CN) materials with ordered morphology and controlled properties. However, the transfer of an intrinsic chemical property, such as chirality from supramolecular assemblies to the final material after thermal condensation, has never been shown. Here, we report the large‐scale synthesis of chiral CN materials capable of enantioselective recognition. To achieve this, we designed supramolecular assemblies with a chiral center that remains intact at elevated temperatures. The optimized chiral CN demonstrates an enantiomeric preference of ca. 14%; CN electrodes were also prepared and show stereoselective interactions with enantiomeric probes in electrochemical measurements. By adding chirality to the properties transferrable from monomers to the final product of a thermal polymerization, this study confirms the potential of using supramolecular precursors to produce carbon and CN materials and electrodes with designed chemical properties.

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Functional mesoporous silica nanoparticles for delivering nimesulide with chiral recognition performance

Cited by 19 publications

References 40 publications

Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and Applications

Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and Applications

Chiral Nanochannels of Ordered Mesoporous Silica Constructed by a Pillar[5]arene-Based Host–Guest System

Polymeric Carbon Nitride with Chirality Inherited from Supramolecular Assemblies

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