Functional Mechanisms of Episodic Memory Impairment in Schizophrenia

Danion, Jean-Marie; Huron, Caroline; Vidailhet, Pierre; Berna, Fabrice

doi:10.1177/070674370705201103

Cited by 123 publications

(94 citation statements)

References 84 publications

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“…3,5,7,10 This was particularly true for episodic verbal memory, which is one of the most impaired memory domains in schizophrenia. 7,78 The effect sizes obtained for AM measures were in the same range, 3,5,7,10 suggesting that AM deficits must be regarded as a major domain of cognitive impairment in schizophrenia. This new finding has probably been under-acknowledged until today, despite that studies have shown that AM deficits are more reliable predictors of patients' reduced social performance than episodic memory (as assessed by traditional laboratory tasks) or clinical symptoms.…”

Section: Autobiographical Memory Deficits In Schizophreniamentioning

confidence: 79%

“…Research on episodic memory has provided evidence of defective strategic processes (due to executive dysfunction) during information encoding in patients with schizophrenia. 78,86 This may reflect patients' difficulty with spontaneously linking and organizing the different aspects of the material to be remembered. 87 These relational memory impairments described in schizophrenia 88,89 point to defective functioning of the hippocampus.…”

Section: Autobiographical Memory Deficits In Schizophreniamentioning

confidence: 99%

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A Meta-Analysis of Autobiographical Memory Studies in Schizophrenia Spectrum Disorder

Berna

Potheegadoo

Aouadi

et al. 2015

SCHBUL

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Meta-analyses and reviews on cognitive disorders in schizophrenia have shown that the most robust and common cognitive deficits are found in episodic memory and executive functions. More complex memory domains, such as autobiographical memory (AM), are also impaired in schizophrenia, but such impairments are reported less often despite their negative impact on patients' outcome. In contrast to episodic memory, assessed in laboratory tasks, memories of past personal events are much more complex and directly relate to the self. The meta-analysis included 20 studies, 571 patients with schizophrenia spectrum disorder, and 503 comparison subjects. It found moderate-to-large effect sizes with regard to the 3 parameters commonly used to assess AM: memory specificity (g = −0.97), richness of detail (g = −1.40), and conscious recollection (g = −0.62). These effect sizes were in the same range as those found in other memory domains in schizophrenia; for this reason, we propose that defective memories of personal past events should be regarded as a major cognitive impairment in this illness.

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Section: Autobiographical Memory Deficits In Schizophreniamentioning

confidence: 79%

Section: Autobiographical Memory Deficits In Schizophreniamentioning

confidence: 99%

A Meta-Analysis of Autobiographical Memory Studies in Schizophrenia Spectrum Disorder

Berna

Potheegadoo

Aouadi

et al. 2015

SCHBUL

Self Cite

View full text Add to dashboard Cite

show abstract

“…1,9,10 Within the domain of memory, recent studies have pointed to a specific deficit of relational memory in schizophrenia. [11][12][13][14][15][16] This provides the opportunity for more translational studies of cognitive impairment in schizophrenia because the neural circuitry and cellular mechanisms of relational memory have been elucidated in rodent and nonhuman primate studies. 17,18 Relational memory provides the ability to remember names with faces, the locations of various objects or people, and the order in which various events occurred.…”

Section: Introductionmentioning

confidence: 99%

Impaired Associative Inference in Patients With Schizophrenia

Armstrong

Köse

Williams

et al. 2010

Schizophrenia Bulletin

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“…The precuneus is located in the posteromedial parietal cortex and plays an important role in a wide spectrum of highly-integrated tasks, including visuo-spatial imagery, episodic memory retrieval, and self-processing operations [55] . These cognitive functions are widely impaired in schizophrenia [56][57][58][59][60][61][62][63] . Moreover, the precuneus has been suggested to be the 'core node' of the default mode network [64] , which has been hypothesized to be relevant to the pathological mechanism of schizophrenia [65][66][67] .…”

Section: Discussionmentioning

confidence: 99%

Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-naïve patients with schizophrenia

Xiang

et al. 2015

Neurosci. Bull.

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The catechol-O-methyltransferase (COMT) gene is a schizophrenia susceptibility gene. A common functional polymorphism of this gene, Val158/158Met, has been proposed to infl uence gray matter volume (GMV). However, the effects of this polymorphism on cortical thickness/ surface area in schizophrenic patients are less clear.In this study, we explored the relationship between the Val158Met polymorphism of the COMT gene and the GMV/ cortical thickness/cortical surface area in 150 firstepisode treatment-naïve patients with schizophrenia and 100 healthy controls. Main effects of diagnosis were found for GMV in the cerebellum and the visual, medial temporal, parietal, and middle frontal cortex. Patients with schizophrenia showed reduced GMVs in these regions. And main effects of genotype were detected for GMV in the left superior frontal gyrus. Moreover, a diagnosis × genotype interaction was found for the GMV of the left precuneus, and the effect of the COMT gene on GMV was due mainly to cortical thickness rather than cortical surface area. In addition, a pattern of increased GMV in the precuneus with increasing Met dose found in healthy controls was lost in patients with schizophrenia. These findings suggest that the COMT Met variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia, and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area.

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Functional Mechanisms of Episodic Memory Impairment in Schizophrenia

Abstract: These findings may explain some behavioural abnormalities associated with schizophrenia, notably, inadequate functional outcomes in everyday life. They may also have implications for cognitive remediation and better social and work functioning of patients with schizophrenia.

Cited by 123 publications

References 84 publications

A Meta-Analysis of Autobiographical Memory Studies in Schizophrenia Spectrum Disorder

A Meta-Analysis of Autobiographical Memory Studies in Schizophrenia Spectrum Disorder

Impaired Associative Inference in Patients With Schizophrenia

Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-naïve patients with schizophrenia

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