Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration

Li, Jialu; Wu, Chengheng; Zeng, Mingze; Zhang, Yusheng; Wei, Dan; Sun, Jing; Fan, Hongsong

doi:10.1039/d3tb01354e

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb01354e

|View full text |Cite

Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration

Jialu Li,

Chengheng Wu,

Mingze Zeng

et al.

Abstract: Nerve injuries and neurological diseases remain intractable clinical challenges. Despite the advantages of stem cell therapy in treating neurological disorders, uncontrollable cell fates and loss of cell function in vivo...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 265 publications

(389 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Nanotechnology‐Fortified Manipulation of Cell Ca²⁺ Signaling

Zhou,

Zhang,

Zhou

et al. 2024

Small Science

View full text Add to dashboard Cite

The manipulation of cytosolic Ca2+ concentration ([Ca2+]i) plays a crucial role in the study of Ca2+ signaling and the therapy of its affected diseases. Nanotechnology enables the development of nanotransducers for targeted, non‐invasive, highly spatiotemporal, and on‐demand [Ca2+]i regulation by responding to external energy fields to activate Ca2+ channels, in situ deliver Ca2+, or release the payload of chemical modulators. As considerable strides have been made in Ca2+ signaling‐related fundamental research and applications in recent years, in this article, it is tried to present a thorough review of nanotransducer‐based [Ca2+]i manipulation, from the working principle to specific applications. Focusing on the design rationale and constructions of nanotransducers, the interactions between nanotransducers and Ca2+ channels are highlighted, as well as the downstream effectors of Ca2+ signaling pathways, followed by their representative biomedical applications in disease treatment and neuromodulation. Moreover, despite the enormous progress made to date, nanotransducer‐regulated Ca2+ signaling still confronts obstacles, and several scientific issues urgently need to be resolved. Thus, to provide brief and valid instructions for the development of nanotransducers for the regulation of Ca2+ signaling, proposals on how to improve the nanotransducer‐based [Ca2+]i manipulation as well as future challenges and prospects are discussed.

show abstract

Nanotechnology‐Fortified Manipulation of Cell Ca²⁺ Signaling

Zhou,

Zhang,

Zhou

et al. 2024

Small Science

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration

Abstract: Nerve injuries and neurological diseases remain intractable clinical challenges. Despite the advantages of stem cell therapy in treating neurological disorders, uncontrollable cell fates and loss of cell function in vivo...

Cited by 1 publication

References 265 publications

Nanotechnology‐Fortified Manipulation of Cell Ca²⁺ Signaling

Nanotechnology‐Fortified Manipulation of Cell Ca²⁺ Signaling

Contact Info

Product

Resources

About

Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration

Abstract: Nerve injuries and neurological diseases remain intractable clinical challenges. Despite the advantages of stem cell therapy in treating neurological disorders, uncontrollable cell fates and loss of cell function in vivo...

Cited by 1 publication

References 265 publications

Nanotechnology‐Fortified Manipulation of Cell Ca2+ Signaling

Nanotechnology‐Fortified Manipulation of Cell Ca2+ Signaling

Contact Info

Product

Resources

About

Nanotechnology‐Fortified Manipulation of Cell Ca²⁺ Signaling

Nanotechnology‐Fortified Manipulation of Cell Ca²⁺ Signaling