Functional mapping of the human motor cortex obtained by focal and vectorial magnetic stimulation of the brain

Ueno, S.; Matsuda, T.; Fujiki, Minoru

doi:10.1109/20.104438

Cited by 117 publications

(39 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The basis of magnetic stimulation is to induce eddy currents in a target by using a time-varying pulsed magnetic field [Barkar et al, 1985;Ueno et al, 1988]. It has been widely applied to neurological research, such as mapping studies of the cerebral cortex [Ueno et al, 1990;Cracco et al, 1999], and cognitive sciences [Grafman and Wassermann, 1998;Bailey et al, 2001]. Recently, many studies have provided clinically effective evidence of transcranial magnetic stimulation (TMS) on neurological disorders such as depression and Parkinson's disease [Fleischmann et al, 1995;George et al, 1995;Keck et al, 2001;Khedr et al, 2003].…”

Section: Introductionmentioning

confidence: 99%

Effects of pulsed magnetic stimulation on tumor development and immune functions in mice

Yamaguchi

Ogiue-Ikeda

Sekino

et al. 2005

Bioelectromagnetics

View full text Add to dashboard Cite

We investigated the effects of pulsed magnetic stimulation on tumor development processes and immune functions in mice. A circular coil (inner diameter = 15 mm, outer diameter = 75 mm) was used in the experiments. Stimulus conditions were pulse width = 238 micros, peak magnetic field = 0.25 T (at the center of the coil), frequency = 25 pulses/s, 1,000 pulses/sample/day and magnetically induced eddy currents in mice = 0.79-1.54 A/m(2). In an animal study, B16-BL6 melanoma model mice were exposed to the pulsed magnetic stimulation for 16 days from the day of injection of cancer cells. A tumor growth study revealed a significant tumor weight decrease in the stimulated group (54% of the sham group). In a cellular study, B16-BL6 cells were also exposed to the magnetic field (1,000 pulses/sample, and eddy currents at the bottom of the dish = 2.36-2.90 A/m(2)); however, the magnetically induced eddy currents had no effect on cell viabilities. Cytokine production in mouse spleens was measured to analyze the immunomodulatory effect after the pulsed magnetic stimulation. tumor necrosis factor (TNF-alpha) production in mouse spleens was significantly activated after the exposure of the stimulus condition described above. These results showed the first evidence of the anti-tumor effect and immunomodulatory effects brought about by the application of repetitive magnetic stimulation and also suggested the possible relationship between anti-tumor effects and the increase of TNF-alpha levels caused by pulsed magnetic stimulation.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of pulsed magnetic stimulation on tumor development and immune functions in mice

Yamaguchi

Ogiue-Ikeda

Sekino

et al. 2005

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…A number of effective homogeneous models of the TMS magnetic field have been proposed [8][9] [10]. Liu and Ueno [11 This author would support that inference and underscore the fact that at the point that positive ions are driven into a nerve cell, its intracellular potential will rise, and if the rise is sufficient, an action potential results.…”

Section: Background Informationmentioning

confidence: 72%

Magnetic field stimulation: the brain as a conductor

Davey¹

2012

Oxford Handbooks Online

View full text Add to dashboard Cite

For the purposes of magnetic stimulation, the brain can be treated as a homogeneous conductor. A properly designed brain stimulation system starts with the target stimulation depth, and it should incorporate the neural strength–duration response characteristics. Higher-frequency pulses require stronger electric fields. The background of this article is the theoretical base determining, where in the brain TMS induces electrical activity, and whether this shifts as a function of differences in the conductivity and organization of gray matter, white matter, and cerebrospinal fluid. The use of strong electric fields to treat many neurological disorders is well established. Both in the treatment of incontinence and clinical depression, the electric field should be sufficiently strong to initiate an action potential. The frequency, system voltage, capacitance, core stimulator size, and number of turns are treated as unknowns in a TMS stimulation design. This article presents the possible topological changes to be considered in the future.

show abstract

“…5 Magnetic stimulation (MS) uses a PMF to induce an electricˆeld in tissues by electromagnetic induction and is a technique that does not require invasive surgery or external electrodes. 28,29 MS has been widely applied to neurological research, such as in studies that map the cerebral cortex 30,31 and cognitive science studies, 32,33 and was recently used clinically for neurological disorders. 22,23 Our group has demonstrated the enhanced killing e‹ciency of imatinib mesylate (IM, Gleevec } , Novartis, East Hanover, NJ, USA) in human breakpoint cluster region-abelson (BCR/ABL) (＋) leukemia cells when the cells were subsequently exposed to MS. 34 BCR/ABL is a chimeric gene, generated by the Philadelphia (Ph) chromosome translocation, t(9;22)(q34;q11), 35 and IM was developed as a potent and speciˆc inhibitor of the BCR/ABL tyrosine kinase.…”

Section: Recent Medical Applications That Use Electromagnetic Fieldsmentioning

confidence: 99%

Biological Effects of Electromagnetic Fields and Recently Updated Safety Guidelines for Strong Static Magnetic Fields

Yamaguchi-Sekino

Sekino

Ueno

2011

MRMS

View full text Add to dashboard Cite

Humans are exposed daily to artiˆcial and naturally occurring magneticˆelds that originate from many diŠerent sources. We review recent studies that examine the biological eŠects of and medical applications involving electromagneticˆelds, review the properties of static and pulsed electromagneticˆelds that aŠect biological systems, describe the use of a pulsed electromagneticˆeld in combination with an anticancer agent as an example of a medical application that incorporates an electromagneticˆeld, and discuss the recently updated safety guidelines for static electromagneticˆelds. The most notable modiˆcations to the 2009 International Commission on Non-Ionizing Radiation Protection guidelines are the increased exposure limits, especially for those who work with or near electromagnetiĉ elds (occupational exposure limits). The recommended increases in exposure were determined using recent scientiˆc evidence obtained from animal and human studies. Several studies since the 1994 publication of the guidelines have examined the eŠects on humans after exposure to high static electromagneticˆelds (up to 9.4 tesla), but additional research is needed to ascertain further the safety of strong electromagneticˆelds.

show abstract

Functional mapping of the human motor cortex obtained by focal and vectorial magnetic stimulation of the brain

Cited by 117 publications

References 20 publications

Effects of pulsed magnetic stimulation on tumor development and immune functions in mice

Effects of pulsed magnetic stimulation on tumor development and immune functions in mice

Magnetic field stimulation: the brain as a conductor

Biological Effects of Electromagnetic Fields and Recently Updated Safety Guidelines for Strong Static Magnetic Fields

Contact Info

Product

Resources

About