Functional Malignant Retroperitoneal Paraganglioma with Liver Metastasis: a Rare Case Report

Kadam, Sachin; Hegde, Sujai; Galage, Amol; Kadam, Tejaswini

doi:10.1007/s13193-020-01259-4

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…It emerged as an independent prognostic factor for the PFS of patients ( p < 0.05), consistent with prior literature 21,22 The disadvantage is that this study failed to perform further genetic testing for negative immunohistochemistry results of SDHB to confirm changes in the gene (or other subunits) to provide guidance for postoperative monitoring of patients and the screening of their relatives. Due to the rarity of RPGL and the primary focus of many domestic and international studies on small sample sizes and case reports, surgical excision is the recommended primary treatment for the initial tumor 23 . Limited treatment options and the presence of metastatic disease, particularly multi‐site metastasis, pose challenges and lead to poor prognoses.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the rarity of RPGL and the primary focus of many domestic and international studies on small sample sizes and case reports, surgical excision is the recommended primary treatment for the initial tumor. 23 Limited treatment options and the presence of metastatic disease, particularly multi-site metastasis, pose challenges and lead to poor prognoses. Based on current clinical consensus, early surgery or comprehensive treatment should be attempted to enhance the survival rates of patients and mitigate the risks associated with poor prognosis evaluations, which may lead to deaths and related complications.…”

Section: Prognosis and Follow-upmentioning

confidence: 99%

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Analysis of clinical and pathological characteristics of retroperitoneal paraganglioma and associated prognostic factors

Chun,

Song,

et al. 2024

Journal of Surgical Oncology

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Background and ObjectivesThe aim of this study is to explore the long‐term prognostic risk factors associated with patients diagnosed with retroperitoneal paraganglioma (RPGL) and examine their clinical and pathological characteristics.MethodsExpressions of biomarkers were identified using immunohistochemistry (IHC) and case databases were retrospectively searched. Survival analysis was performed using Kaplan‐Meier and Cox risk regression to identify the factors that influence the postoperative progression‐free survival of patients with RPGL.ResultsA total of 105 patients, most of whom had tumors situated in the paraaortic region, and whose average tumor size was 8.6 cm, were enrolled in this study. The average follow‐up duration was 51 months, with a mortality rate of 19% and a recurrence and metastasis rate of 41.9%. Tumors were assessed using the modified Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP), and SDHB, S‐100, and Ki‐67 were stained using IHC in all cases. Out of the total cases examined, negative in SDHB expression were observed in 18.1% of cases, S‐100 expression was negative in 36.2% of cases, and endovascular tumor enboluswas present in approximately 25.7% of cases. The results of the univariate analysis indicated that several factors significantly influenced the progression‐free survival of patients with PGL as follow: maximum tumor diameter (>5.5 cm), tumor morphological features, tumor grading (modified GAPP score > 6), SDHB negative, S‐100 negative, and expression of proliferation index Ki‐67 (>3%) (X2 = 4.217−27.420, p < 0.05). The results of the multivariate analysis indicated that negative of S‐100 (p = 0.021) and SDHB (p = 0.038), as well as intravascular tumor thrombus (p = 0.047) expression were independent risk factors for progression‐free survival in patients.ConclusionRPGL is characterized by diverse biological features and an elevated susceptibility to both recurrence and metastasis. Both SDHB and S‐100 can be employed as traditional IHC indicators to predict the metastatic risk of PGL, whereas the tumor histomorphology‐endovascular tumor enbolus assists in determining the metastasis risk of RPGL.

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Section: Discussionmentioning

confidence: 99%

Section: Prognosis and Follow-upmentioning

confidence: 99%

Analysis of clinical and pathological characteristics of retroperitoneal paraganglioma and associated prognostic factors

Chun,

Song,

et al. 2024

Journal of Surgical Oncology

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“…Paragangliomas are further classified as functioning and non-functioning tumors. Functioning paragangliomas are manifested by the classic Menards triad: Cephalgia, Tachycardia and diaphoresis [1] , [2] , [4] , [6] , [8] , [11] , [13] , [16] . In our case symptoms were a result of catecholamine hypersecretion which included severe headache and transient loss of sight (complication of severe hypertension).…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal paraganglioma in a young patient presenting with hypertensive crisis and transient loss of sight; a rare case report and literature review

Mulenga¹,

Kazuma²,

Nonde³

et al. 2022

International Journal of Surgery Case Reports

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Functional Malignant Retroperitoneal Paraganglioma with Liver Metastasis: a Rare Case Report

Cited by 2 publications

References 17 publications

Analysis of clinical and pathological characteristics of retroperitoneal paraganglioma and associated prognostic factors

Analysis of clinical and pathological characteristics of retroperitoneal paraganglioma and associated prognostic factors

Retroperitoneal paraganglioma in a young patient presenting with hypertensive crisis and transient loss of sight; a rare case report and literature review

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