Functional magnetic resonance imaging of the central auditory pathway following speech and pure‐tone stimuli

Millen, Steven J.; Haughton, Victor M.; Yetkin, Z.

doi:10.1288/00005537-199512000-00008

Cited by 64 publications

(48 citation statements)

References 10 publications

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“…The activation during both tasks was generally larger in the left hemisphere for both groups of subjects. This is consistent with other fMRI reports showing that tones and white noise, respectively, activated the superior temporal gyrus and produced a more pronounced response in the left hemisphere (27,28).…”

Section: Discussionsupporting

confidence: 93%

A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia

Wible¹

2001

American Journal of Psychiatry

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Objective-Previous research has noted functional and structural temporal lobe abnormalities in schizophrenia that relate to symptoms such as auditory hallucinations and thought disorder. The goal of the study was to determine whether the functional abnormalities are present in schizophrenia at early stages of auditory processing.Method-Functional magnetic resonance imaging activity was examined during the presentation of the mismatch stimuli, which are deviant tones embedded in a series of standard tones. The mismatch stimuli are used to elicit the mismatch negativity, an early auditory event-related potential. Ten patients with schizophrenia and 10 comparison subjects were presented the mismatch stimuli condition and a control condition in which only one tone was presented repeatedly.Results-The superior temporal gyrus showed the most prevalent and consistent activation. The superior temporal gyrus showed less activation in the schizophrenic subjects than in the comparison subjects only during the mismatch stimuli condition.Conclusions-This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia.The mismatch negativity is a negative-going brain potential elicited between 150 and 250 msec after the presentation of a deviant stimulus within a repetitive pattern (1) and is usually measured by subtracting the level of activity elicited by the standard stimuli from the level of activity elicited by the deviant stimuli. Naatanen and Gaillard (2) proposed that the mismatch negativity was evoked preattentively and that it indexed an echoic memory comparison of a stimulus to the neural trace of previous stimuli (3,4). Thus, the mismatch negativity is the earliest identified cortical event-related potential that is elicited by deviant, infrequent auditory stimuli and that occurs independently of whether or not the stimuli are consciously attended (5).Our laboratory recently used high-density event-related potential recording during a mismatch negativity paradigm and found an event-related potential scalp topography abnormality in schizophrenic subjects that was localized to the parietotemporal junction (6) and that was slightly more pronounced on the left. Mismatch negativity amplitude also correlated with several measures of psychopathology in that study, including the severity of auditory hallucinations. In two studies, no mismatch negativity event-related potential abnormalities were found in patients with schizophrenia at their first hospitalization, indicating a functional abnormality that may develop with disease chronicity (7,8).The current study used functional magnetic resonance imaging (fMRI) to examine brain activity during presentation of the mismatch stimuli to schizophrenic and comparison subjects. Several fMRI studies involving schizophrenic subjects (9) have found abnormal activity in the temporal lobe (as well as other regions) (10-12). The mismatch stimuli and tone repetition condition...

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Section: Discussionsupporting

confidence: 93%

A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia

Wible¹

2001

American Journal of Psychiatry

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“…In contrast to subcortical structures, auditory cortex has been examined in a substantial number of fMRI studies concerning sound-level dependencies (Millen et al, 1995;Jäncke et al, 1998;Mohr et al, 1999;Bilecen et al, 2002;Brechmann et al, 2002;Hall et al, 2001;Hart et al, 2002;Lasota et al, 2003;Hart et al, 2003;Mulert et al, 2005). All of these showed increases in fMRI activation magnitude and/or extent with increasing level using pure tone, complex tone, frequency modulated or speech stimuli.…”

Section: Comparison To Previous Imaging Studies Of Sound Levelmentioning

confidence: 99%

Effects of sound level on fMRI activation in human brainstem, thalamic and cortical centers

Sigalovsky

Melcher

2006

Hearing Research

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The dependence of fMRI activation on sound level was examined throughout the auditory pathway of normal human listeners using continuous broadband noise, a stimulus widely used in neuroscientific investigations of auditory processing, but largely neglected in neuro-imaging. Several specialized techniques were combined here for the first time to enhance detection of brainstem activation, mitigate scanner noise, and recover temporal resolution lost by the mitigation technique. The main finding was increased activation with increasing level in cochlear nucleus, superior olive, inferior colliculus, medial geniculate body and auditory cortical areas. We suggest that these increases reflect monotonically increasing activity in a preponderance of individual auditory neurons responsive to broadband noise. While the time-course of activation changed with level, the change was subtle and only significant in a part of the cortex. To our knowledge, these are the first fMRI data showing the effects of sound level in subcortical centers or for a non-tonal, non-speech stimulus at any stage of the pathway. The present results add to the body of parametric data in normal human listeners and are fundamental to the design of any fMRI experiment employing continuous noise.

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“…Neuroimaging studies of sound intensity Both fMRI and positron emission tomography (PET) studies have measured systematic changes in auditory activation with sound level, particularly on the supratemporal plane and superior temporal gyrus (e.g., Jäncke et al, 1998;Lockwood et al, 1999;Millen et al, 1995;Mohr et al, 1999;Strainer et al, 1997). Results have generally indicated a growth in auditory activation with sound level.…”

Section: Introductionmentioning

confidence: 99%

Functional magnetic resonance imaging measurements of sound-level encoding in the absence of background scanner noise

Hall

Haggard

Summerfield

et al. 2001

The Journal of the Acoustical Society of America

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Effects of sound-level on auditory cortical activation are seen in neuroimaging data. However, factors such as the cortical response to the intense ambient scanner noise and to the bandwidth of the acoustic stimuli will both confound precise quantification and interpretation of such sound-level effects. The present study used temporally "sparse" imaging to reduce effects of scanner noise. To achieve control for stimulus bandwidth, we compared 3 schemes for sound-level matching across bandwidth: component level, root mean square power and loudness. The calculation of the loudness match was based on the model reported by Moore et al. (1996). Ten normally-hearing volunteers were scanned using fMRI whilst listening to a 300-Hz tone presented at six different sound levels between 66 and 91 dB SPL and a harmonic-complex tone (F 0 = 186 Hz) presented at 65 and 85 dB SPL. This range of sound levels encompassed all three bases of sound-level matching. Activation in the superior temporal gyrus, induced by each of the 8 tone conditions relative to a quiet baseline condition, was quantified as to extent and magnitude. Sound level had a small, but significant, effect on the extent of activation for the pure tone, but not for the harmonic-complex tone, whilst it had a significant effect on the response magnitude for both types of stimulus. Response magnitude increased linearly as a function of sound level for the full range of levels for the pure tone. The harmoniccomplex tone produced greater activation than the pure tone, irrespective of the matching scheme for sound level, indicating that bandwidth had a greater effect on the pattern of auditory activation than sound level. Nevertheless, when the data were collapsed across stimulus class, extent and magnitude were significantly correlated with the loudness scale (measured in phons), but not with the intensity scale (measured in SPL). We therefore recommend the loudness formula as the most D.Hall "fMRI measurements of sound-level encoding" 2 appropriate basis of matching sound level to control for loudness effects when cortical responses to other stimulus attributes, such as stimulus class, are the principal concern.

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Functional magnetic resonance imaging of the central auditory pathway following speech and pure‐tone stimuli

Cited by 64 publications

References 10 publications

A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia

A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia

Effects of sound level on fMRI activation in human brainstem, thalamic and cortical centers

Functional magnetic resonance imaging measurements of sound-level encoding in the absence of background scanner noise

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