Functional magnetic resonance imaging mirrors recovery of visual perception after repetitive tachistoscopic stimulation in patients with partial cortical blindness

Pleger, Burkhard; Foerster, Ann-Freya; Widdig, W.; Henschel, Markus; Nicolas, Volkmar; Jansen, Andreas; Frank, Andreas; Knecht, Stefan; Schwenkreis, Peter; Tegenthoff, Martin

doi:10.1016/s0304-3940(02)01153-9

Cited by 35 publications

(25 citation statements)

References 13 publications

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“…Although multiple processes may be involved, and the precise mechanisms remain to be elucidated, it is possible that cortical reorganization may play a role in the detected changes in visual fields. This concept is supported by neuroimaging data: cortical activation changes have been reported after Vision Restoration Therapy on functional MRI [22]; others have shown occipital changes on PET [23], and in BOLD signal with functional MRI in cortically blind individuals after a repetitive visual stimulation task different from VRT [24]. Localized attention may also play a role in improvement of stimulus detection at the border of the hemianopic field [9].…”

Section: Discussionmentioning

confidence: 81%

Visual field changes after a rehabilitation intervention: Vision restoration therapy

Romano

Schulz²,

Kenkel³

et al. 2008

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 81%

Visual field changes after a rehabilitation intervention: Vision restoration therapy

Romano

Schulz²,

Kenkel³

et al. 2008

Journal of the Neurological Sciences

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“…First, with treatment, significant recovery of function has been shown to occur in a range of specific cognitive abilities including aphasia (Cornelissen et al, 2003;Pulvermuller et al, 2001), cortical blindness (Pleger et al, 2003), unilateral neglect (Pizzamiglio et al, 1998), sustained attention (Longoni et al, 2000) and dyslexia in children (Temple et al, 2003). In each case treatment has focused attention on the relevant processes and applied carefully targeted, graduated practice.…”

Section: Introductionmentioning

confidence: 99%

Treating deficits in emotion perception following traumatic brain injury

Bornhofen

McDonald

2008

Neuropsychological Rehabilitation

101

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The present research aimed to investigate whether social perception deficits commonly experienced in the adult traumatic brain injury (TBI) population can be successfully remediated through cognitive rehabilitation. Twelve outpatient volunteers (11 male, 1 female; age range 20-57 years) with severe, chronic TBI (mean length of post-traumatic amnesia 121 days, range 58-210 days; mean months post- injury 93.58, range 17-207 months) participated in a randomised controlled trial. Participants were randomly allocated to treatment and waitlist control groups following assessment on a range of emotion perception and psychosocial measures. Treatment comprised 25 hours, across 8 weeks, of a programme specifically designed to address emotion perception which incorporated a variety of remediation techniques shown to be effective with the TBI population. Results indicated that participants significantly improved both in judging basic emotional stimuli when presented in a naturalistic format (i.e., video vignettes) and in making social inferences on the basis of speaker demeanour. This is the first known treatment study dealing with emotion perception deficits in individuals with TBI.

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“…Die applizierte Blitzlichtstimulation (1200 cd/m 2 ; 3 Hz) evoziert bei gesunden Probanden eine globale Aktivierung der Sehrinde [13]. Wir benutzten eine isotropische Spinecho-EPISequenz (TR 4294 ms, TE 50 ms, Matrix 64x64, 192 mm "field of view", 3 mm Schichtdicke,3×3×3 mm Voxelgröße) mit 44 transaxial ausgerichteten Schichten parallel zur AC-PC-Linie (Verbindungslinie zwischen der Commisura anterior und posterior) eingestellt und das gesamte Gehirnvolumen einschließend.…”

Section: Ausdehnung Der Bold-(blood-oxygen-level-dependent-)aktivitätunclassified

“…Diese Patienten boten bei der klinischen Untersuchung ein residuales Hell-Dunkel-Sehen. Die Aktivität im visuellen Kortex war dabei erwartungsgemäß hauptsächlich auf die den Stimulationsreiz primär verarbeitenden Hirnregionen V1 und V2 (Brodman-Areale 17 und 18) begrenzt [13]. Die nachgeschalteten Regionen des visuellen Kortex waren dabei entsprechend der im konventionellen MRT auffälligen läsionsbedingten Destruktion inaktiv.…”

Section: Ausdehnung Der Bold-(blood-oxygen-level-dependent-)aktivitätunclassified

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Visusst�rungen beim Tolosa-Hunt-Syndrom

Pleger

Förster

Schwenkreis

et al. 2004

Schmerz

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Besides painful ophthalmoplegia, patients suffering from Tolosa-Hunt syndrome often present increasing loss of visual perception. The impairment of the optic nerve leads to a delay of the VEP (visual evoked potentials) responses. Using the method of magnetic resonance imaging (MRI), some patients present unspecific alterations in the vicinity of the optic nerve. However, both methods (VEP and MRI) are unsuitable to assess the effect of an impaired optic nerve function on neuronal processing in the visual cortex. We report one patient suffering from Tolosa-Hunt syndrome affecting the optic nerve. We used fMRI (functional magnetic resonance imaging) to show how this impairment of the optic nerve alters cortical processing of visual information. The activity of the unaffected visual cortex was bilaterally reduced when compared to healthy volunteers but greater that obtained from patients suffering from bilateral occipital infarction. Our results offer new opportunities to assess the efficiency of therapy in patients with increasing loss of visual perception due to the Tolosa-Hunt syndrome. Further studies are necessary to investigate, whether fMRI also provides the possibility to assess the efficiency of drug therapy on optic nerve function.

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Functional magnetic resonance imaging mirrors recovery of visual perception after repetitive tachistoscopic stimulation in patients with partial cortical blindness

Cited by 35 publications

References 13 publications

Visual field changes after a rehabilitation intervention: Vision restoration therapy

Visual field changes after a rehabilitation intervention: Vision restoration therapy

Treating deficits in emotion perception following traumatic brain injury

Visusst�rungen beim Tolosa-Hunt-Syndrom

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