Functional magnetic resonance imaging for the determination of blood flow in symmetric uterine anomalies

Makiyan, Z.; Adamyan, Adamyan L.V.; Bychenko, V.G.; Miroshnikova, Miroshnikova N.A.; Kozlova, Kozlova A.V.

doi:10.18565/aig.2016.10.73-9

Cited by 1 publication

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“…Successful pregnancy without metroplasty has been found to be possible in 46% of these cases, depending on vascularization of the septum. However, in 54% of patients, microcirculation in the complete intrauterine septum was found to be reduced to 22–35% of that in the myometrium, resulting in a need for resection of the septum (Makiyan, Adamyan, Bychenko, Miroshnikova, & Kozlova, 2016). Functional (DCE) MRI is required for estimation of blood perfusion in the complete septum in non‐pregnant (or infertile) patients.…”

Section: Resultsmentioning

confidence: 99%

“…Hysteroresectoscopy identifies poor blood flow in the fibrous septum. Histological morphometry of the septum detects severe reduction and malformation of microcirculatory blood vessels (Makiyan et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…Functional (DCE) MRI is required for estimation of blood perfusion in the complete septum in non-pregnant (or infertile) patients. Operative treatment is preferred when blood perfusion is reduced by ≥20% in the septum as compared to the myometrium, or in those with a history of miscarriage (Makiyan et al, 2016). The endometrial cavity may be connected to the ipsilateral fallopian tube or may even be enclosed (Figure 7b).…”

Section: Type 4 Double Uterus and Vaginamentioning

confidence: 99%

“…Asymmetric uterovaginal variations were found in up to 64% of those with concomitant urinary tract variations (aplasia). (Makiyan et al, 2016). This atypical form is an extremely rare anatomic variant, where a partial septum persists in the uterine cavity and in the vagina.…”

Section: Type 4 Double Uterus and Vaginamentioning

confidence: 99%

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Systematization for female genital anatomic variations

Makiyan

2020

Clinical Anatomy

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Introduction Congenital variations of the reproductive system arise during embryonal organogenesis, although their clinical manifestations present later in adolescence or during reproductive years due to functional disorders such as abnormal menstruation, sexual dysfunction, infertility, and pregnancy loss. Surgical treatment of congenital variations is performed according to variant anatomy and functional disorders. However, many congenital anatomic variations are difficult to categorize based on current classification systems. The aim of this study is to distinguish female genital anatomic variations for appropriate surgical treatment based on a clinical analysis of uterovaginal malformations and disorders of sex development. The deviant anatomy defined as variations, which has been used in the manuscript instead of anomalies. Materials and methods A retrospective review was conducted of 718 cases of uterovaginal malformation and 144 cases with disorders of sex development. Physical variations were assessed by ultrasound, magnetic resonance imaging, and laparoscopy. Genetic studies were conducted for individuals with disorders of sex development. Classification of variants was determined by physical findings, genetic findings, and clinical presentations. Results A unified systematization for female genital anatomic variations was proposed, based on the genome (karyotype), gonadal morphology, internal and external genital anatomy. The internal anatomy was classified to uterovaginal variations, which have distinguished to 11 basic types and 24 variants, according to morphologic patterns. Surgical treatments are proposed based on these variants. Conclusion These new classifications provide a framework for clinical management and appropriate surgical treatment of female genital anatomic variants, with the aim of improving reproductive outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Type 4 Double Uterus and Vaginamentioning

confidence: 99%

Section: Type 4 Double Uterus and Vaginamentioning

confidence: 99%

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