Functional limitations in functional somatic syndromes and well-defined medical diseases. Results from the general population cohort LifeLines

Joustra, Monica L.; Janssens, Karin A.M.; Bültmann, Ute; Rosmalen, Judith

doi:10.1016/j.jpsychores.2015.05.004

Cited by 84 publications

(64 citation statements)

References 47 publications

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“…[27, 28] Given the early onset of epilepsy in the lives of many PWE, it is perhaps not surprising that the burden of managing epilepsy impedes the attainment of occupational goals and adequate financial resources. [29] It is possible that evidence-based approaches for epilepsy self-management initiated early, for instance in adolescence and emerging adulthood, may help with maximizing occupational achievement and future income levels for PWE.…”

Section: Discussionmentioning

confidence: 99%

Correlates of quality of life among individuals with epilepsy enrolled in self-management research

Sajatovic

Tatsuoka

Welter

et al. 2017

Epilepsy & Behavior

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Rationale: Epilepsy is a chronic neurological condition that causes substantial burden on patients and families. Quality of life may be reduced due to the stress of coping with epilepsy. For nearly a decade, the Centers for Disease Control (CDC) Prevention Research Center’s Managing Epilepsy Well (MEW) Network has been conducting research on epilepsy self-management to address research and practice gaps. Studies have been conducted by independent centers across the U.S. Recently, the MEW Network sites, collaboratively, began compiling an integrated database to facilitate aggregate secondary analysis of completed and ongoing studies. In this preliminary analysis, correlates of quality of life in people with epilepsy (PWE) were analyzed from pooled baseline data from the MEW Network. Methods: For this analysis, data originated from 6 epilepsy studies conducted across 4 research sites and comprised 459 PWE. Descriptive comparisons assessed common data elements that included gender, age, ethnicity, race, education, employment, income, seizure frequency, quality of life, and depression. Standardized rating scales were used for quality of life (QOLIE-10) and for depression (Patient Health Questionnaire, PHQ-9). Results: While not all datasets included all common data elements, baseline descriptive analysis found a mean age of 42 (SD 13.22), 289 women (63.0%), 59 African Americans (13.7%), 58 Hispanics (18.5%). Most, 422 (92.8%), completed at least high school, while 169 (61.7%) were unmarried, divorced/separated, or widowed. Median 30-day seizure frequency was 0.71 (range 0-308). Depression at baseline was common, with a mean PHQ-9 score of 8.32 (SD 6.04); 69 (29.0%) had depression in the mild range (PHQ-9 score 5-9) and 92 (38.7%) had depression in the moderate to severe range (PHQ-9 score > 9). Lower baseline quality of life was associated with greater depressive severity (p <.001), more frequent seizures (p<.04) and lower income (p<.05). Conclusions: The MEW Network integrated database offers a unique opportunity for secondary analysis of data from multiple community-based epilepsy research studies. While findings must be tempered by potential sample bias, i.e. a relative under-representation of men and relatively small sample of some racial/ethnic subgroups, results of analyses derived from this first integrated epilepsy self-management database have potential to be useful to the field. Associations between depression severity and lower QOL in PWE are consistent with previous studies derived from clinical samples. Self-management efforts that focus on mental health comorbidity and seizure control may be one way to address modifiable factors that affect quality of life in PWE.

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Section: Discussionmentioning

confidence: 99%

Correlates of quality of life among individuals with epilepsy enrolled in self-management research

Sajatovic

Tatsuoka

Welter

et al. 2017

Epilepsy & Behavior

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“…High health anxiety is an additional, independent predictor of health care use [14,15]. Impaired quality of life and work participation in the FSS are at least as severe as those found in well-defined medical diseases with comparable symptoms [16,17]. Long-term outcome of FSS/bodily distress is variable, but for patients with multiple bodily symptoms it is poor with high rates of disability and sick leave [18].…”

Section: The Clinical Problem: a Matter Of Perspectivementioning

confidence: 99%

“…In terms of comorbidity, FSS (e.g., IBS and fibromyalgia) and bodily distress in general are associated with higher rates of depression and anxiety than diseases with comparable symptoms attributable to well-defined organic pathology (e.g., inflammatory bowel disease vs. rheumatoid arthritis) [17]. However, many cases of FSS also occur without anxiety or depression; thus, the association between FSS and psychiatric disorder can neither be regarded as a psychological reaction to the bodily symptoms nor as a manifestation of masked or somatized depression or anxiety [20].…”

Section: The Clinical Problem: a Matter Of Perspectivementioning

confidence: 99%

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Management of Functional Somatic Syndromes and Bodily Distress

Henningsen

Zipfel²,

Sattel³

et al. 2018

Psychother Psychosom

231

182

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Functional somatic syndromes (FSS), like irritable bowel syndrome or fibromyalgia and other symptoms reflecting bodily distress, are common in practically all areas of medicine worldwide. Diagnostic and therapeutic approaches to these symptoms and syndromes vary substantially across and within medical specialties from biomedicine to psychiatry. Patients may become frustrated with the lack of effective treatment, doctors may experience these disorders as difficult to treat, and this type of health problem forms an important component of the global burden of disease. This review intends to develop a unifying perspective on the understanding and management of FSS and bodily distress. Firstly, we present the clinical problem and review current concepts for classification. Secondly, we propose an integrated etiological model which encompasses a wide range of biopsychosocial vulnerability and triggering factors and considers consecutive aggravating and maintaining factors. Thirdly, we systematically scrutinize the current evidence base in terms of an umbrella review of systematic reviews from 2007 to 2017 and give recommendations for treatment for all levels of care, concentrating on developments over the last 10 years. We conclude that activating, patient-involving, and centrally acting therapies appear to be more effective than passive ones that primarily act on peripheral physiology, and we recommend stepped care approaches that translate a truly biopsychosocial approach into actual management of the patient.

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“…Currently, an increase in the number of FM investigators is considered as functional and somatic pathology [6,7].…”

Section: Introductionmentioning

confidence: 99%

Chronic Pain and Depression

Karapetyan¹,

Manvelyan²

2017

Depression

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Today, it is clear that chronic pain and depression are closely related. Depression can cause pain, and chronic pain can cause depression too. According to the American Pain Foundation, about 32 million people in the U.S. report have had pain lasting longer than 1 year. Statistical international data prove that more than half of the patients with pain are depressed or have mood swings, and on average, 65% of depressed people also complain of pain. Patients simultaneously sufering of chronic pain and limited independence are especially vulnerable. Fibromyalgia (FM) is one of the most common chronic pain syndromes, afecting 15 up to 5% of world population, is characterized as difuse widespread body pain, with deinite tender points and clinical features, and also triggers the development of depression. Depression severity in patients with FM worsens severity of pain. Depressive disorders are observed in approximately 90% of patients with FM. Pain triggers development of depressive conditions in patients with chronic character of pain, and time course of disease shows certain patern of increasing of severity of depression and worsens long term outcomes. Patients with chronic pain must be evaluated for depression, and successful management of pain must include treatment of depressive mood too.

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Functional limitations in functional somatic syndromes and well-defined medical diseases. Results from the general population cohort LifeLines

Abstract: Functional limitations in FSS patients are common, and as severe as those in patients with MD when looking at QoL and work participation, emphasizing that FSS are serious health conditions.

Cited by 84 publications

References 47 publications

Correlates of quality of life among individuals with epilepsy enrolled in self-management research

Correlates of quality of life among individuals with epilepsy enrolled in self-management research

Management of Functional Somatic Syndromes and Bodily Distress

Chronic Pain and Depression

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