Functional (ischemic) mitral regurgitation in acute phase of myocardial infarction: Associated clinical factors and in-hospital outcomes

Valuckienė, Živilė; Urbonaitė, Dominyka; Jurkevičius, Renaldas

doi:10.1016/j.medici.2015.02.003

Cited by 10 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is reported that moderate and severe MR in acute MI is related to increased left ventricular diastolic dimensions. 8 Fazlinezhad and colleagues 10 reported higher grade of diastolic dysfunction, end-diastolic LV pressure in IMR cases. They also had higher Systolic Pulmonary Artery Pressure (SPAP) which was related directly to the severity of MR. MacHaalany et al 9 also showed higher prevalence of PAP, LVESD and LA size in moderate to severe IMR.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Correlation between echocardiographic severity of ischemic mitral valve regurgitation following acute myocardial infarction and its electrocardiographic location

Toufan

Hadi

Habibzadeh

2018

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

Introduction: Ischemic mitral regurgitation (IMR) is common after acute myocardial infarction (AMI) which is associated with long-term cardiovascular mortality. Size, transmurality and location of the myocardial infarction (MI) has role on the development of IMR. In this study we evaluated the severity of IMR after different types of MI. Methods: One-hundred patients with the first AMI were recruited and according to echocardiographic findings were categorized to have moderate to severe IMR (case group, n=50) or trivial or no IMR (control group, n=50). Demographic and echocardiographic findings and MI location were compared between groups. Results: Case group compared to control group had significantly higher Killip class, more cases with left ventricular ejection fraction (LVEF) <30% and inferolateral STEMI. They had significantly higher left ventricular (LV) and right ventricular (RV) diastolic dysfunction. Mechanism of IMR was mono leaflet tethering in 88%, both leaflets tethering in 12% and ring dilatation in 62%. MR jet origin-direction was medial commisure-posterior in 66%, lateral commisure-anterior in 11 22% and both commisure-central direction in 12%. Conclusion: IMR is common after AMI, especially in cases with inferior MI. The echocardiographic findings are indicative of left ventricular remodeling and abnormality of mitral valve apparatus.

show abstract

Section: Discussionmentioning

confidence: 94%

“…We observed that cases with IMR are more female, older and smoker. In the literature, cases with moderate to severe IMR were older, 8 with female dominance. 9 …”

Section: Discussionmentioning

confidence: 99%

Correlation between echocardiographic severity of ischemic mitral valve regurgitation following acute myocardial infarction and its electrocardiographic location

Toufan

Hadi

Habibzadeh

2018

J Cardiovasc Thorac Res

View full text Add to dashboard Cite

show abstract

“…Patients at risk are elder, more likely to be female, to have lower EF and multi-vessel CAD, these findings are well acknowledged in previous reports. [18][19][20] Many factors contribute to the occurrence of IMR, including postinfarct LV remodeling, papillary muscle displacement, contractile dysfunction of the left ventricle, structural changes of the valvular ring, and ventricular electro-mechanical dys-synchrony. 5,6 Of these factors, left ventricular remodeling is thought to be the most important mechanism responsible for IMR.…”

Section: Discussionmentioning

confidence: 99%

Impact of percutaneous reperfusion on ischemic mitral regurgitation in patients presented with inferior ST-segment elevation myocardial infarction

Abouomar¹,

Shouib²,

Hassan³

et al. 2021

JCCR

View full text Add to dashboard Cite

Background: Ischemic mitral regurgitation (IMR) is a common complication of acute inferior ST elevation myocardial infarction (MI). Current evidences suggest that revascularization of the culprit vessels with primary percutaneous coronary artery intervention (PCI) or coronary artery bypass grafting can be beneficial for relieving IMR. The aim was to study the effect of successful primary percutaneous coronary intervention (PCI) of the culprit vessel on the degree of ischemic mitral regurgitation in patients with acute inferior STEMI.Patients and methods: 200 patients diagnosed as acute inferior STEMI with ischemic MR & subjected for primary percutaneous coronary intervention (PCI). Assessment of LV function and dimensions by echocardiography and assessment degree of mitral regurgitation by jet area before and after PCI.Result: Mean MR jet area decreased from (5.3±2.2 cm 2 ) to (3.2±2.5cm 2 ), (p value<0.05) after PCI, and this improvement in MR was evident in all degrees of MR. There was a significant improvement in the degree of MR among non-diabetic patients in comparison with diabetic patients. Shorter onset-to-reperfusion time and no total occlusion before PCI were the independent predictors of early improvement of IMR. Conclusion:PPCI in Patients with ischemic mitral regurgitation associated with inferior STEMI led to a decrease in the severity of mitral regurgitation at 40days post PCI. No further improvement in the severity of mitral regurgitation occurred after 40days post PCI. Patients with moderate and severe mitral incompetence after 40days had a higher incidence of hospitalization with decompensated heart failure and more left ventricular remodeling changes at 6 months follow up.

show abstract

“…Mean platelet volume, which reflects the platelet production and function, is associated with MR severity and thromboembolism risk[49, 50]. In terms of electrocardiographic markers, reduced LVEF, increased left atrial dimensions and left ventricular end diastolic diameter have been found to predict MR severity, which is associated with increased in-hospital cardiac death risk and overall mortality[47, 51, 52]. P wave indices reflective of left atrial remodeling, such as P wave area and P wave terminal force, was predictive of MR severity[11, 12].…”

Section: Discussionmentioning

confidence: 99%

Predicting Stroke and Mortality in Mitral Regurgitation: A Gradient Boosting Approach

Zhou

Lee²,

Liu³

et al. 2021

Preprint

View full text Add to dashboard Cite

IntroductionWe hypothesized that an interpretable gradient boosting machine (GBM) model considering comorbidities, P-wave and echocardiographic measurements, can better predict mortality and cerebrovascular events in mitral regurgitation (MR).MethodsPatients from a tertiary center were analyzed. The GBM model was used as an interpretable statistical approach to identify the leading indicators of high-risk patients with either outcome of CVAs and all-cause mortality.ResultsA total of 706 patients were included. GBM analysis showed that age, systolic blood pressure, diastolic blood pressure, plasma albumin levels, mean P-wave duration (PWD), MR regurgitant volume, left ventricular ejection fraction (LVEF), left atrial dimension at end-systole (LADs), velocity-time integral (VTI) and effective regurgitant orifice were significant predictors of TIA/stroke. Age, sodium, urea and albumin levels, platelet count, mean PWD, LVEF, LADs, left ventricular dimension at end systole (LVDs) and VTI were significant predictors of all-cause mortality. The GBM demonstrates the best predictive performance in terms of precision, sensitivity c-statistic and F1-score compared to logistic regression, decision tree, random forest, support vector machine, and artificial neural networks.ConclusionGradient boosting model incorporating clinical data from different investigative modalities significantly improves risk prediction performance and identify key indicators for outcome prediction in MR.

show abstract

Functional (ischemic) mitral regurgitation in acute phase of myocardial infarction: Associated clinical factors and in-hospital outcomes

Abstract: Moderate and severe MR in acute MI is related to age, atrial fibrillation, increased left ventricular diastolic dimensions and decreased ejection fraction. Moderate and severe, but not mild MR is an important clinical contributor to in-hospital cardiac death.

Cited by 10 publications

References 18 publications

Correlation between echocardiographic severity of ischemic mitral valve regurgitation following acute myocardial infarction and its electrocardiographic location

Correlation between echocardiographic severity of ischemic mitral valve regurgitation following acute myocardial infarction and its electrocardiographic location

Impact of percutaneous reperfusion on ischemic mitral regurgitation in patients presented with inferior ST-segment elevation myocardial infarction

Predicting Stroke and Mortality in Mitral Regurgitation: A Gradient Boosting Approach

Contact Info

Product

Resources

About