Functional intravital imaging of hepatotoxicity: Comparing intact livers to 3D in vitro systems

Hengstler, Jan G.; Drasdo, Dirk; Cellière, Géraldine; Hammad, Seddik; Ghallab, Ahmed; Reif, Raymond; Marchan, Rosemarie; Fluri, David; Kelm, Jens M.; Godoy, Patrício

doi:10.1016/j.toxlet.2015.08.103

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Level 3: Multicellular Tissue and Organ Level1

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2016

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“…This level includes in vitro tests such as the CTAs, which may also be at Level 2: The SHE assay can be utilized for the first steps of the multistep carcinogenic process, whilst the Balb 3T3 and C3H10T1/2 CTA assays are designed to address the later steps of a carcinogenic process. At this level, also 3D liver cell models (Hengstler et al, 2015;Prestigiacomo and Suter-Dick, 2015;Ramachandran et al, 2015;van Grunsven, 2015) and isolated organ studies, such as tissue perfusion and histopathology from in vivo repeated dose studies would be relevant.…”

Section: Level 3: Multicellular Tissue and Organ Levelmentioning

confidence: 99%