Functional interactions between post-translationally modified amino acids of methyl-coenzyme M reductase inMethanosarcina acetivorans

Abstract

19Methyl-coenzyme M reductase (MCR) plays an important role in mediating 20 global levels of methane by catalyzing a reversible reaction that leads to the production or 21 consumption of this potent greenhouse gas in methanogenic and methanotrophic archaea. 22Although the methane-oxidizing activity of MCR in anaerobic methane-oxidizing 49 archaea (also referred to as ANME) leads to the consumption of ca. 90% of the methane 50 produced in marine sediments (3, 4), the methanogenic activity of MCR dominates, 51 leading to the net production of ca.