1995
DOI: 10.1523/jneurosci.15-03-02179.1995
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Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons

Abstract: The possible interaction of melatonin receptors and D1 dopamine receptors was investigated in neural cells prepared from embryonic day 8 chick retinas and cultured for 6 d. Dopamine stimulated cAMP accumulation in cultured retinal cells. This effect of dopamine was antagonized by addition of dopamine receptor antagonists (haloperidol and SCH23390) or melatonin receptor agonists (melatonin, 2- iodomelatonin, and 6-chloromelatonin). The inhibition of dopamine- stimulated cAMP accumulation by melatonin was concen… Show more

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Cited by 76 publications
(37 citation statements)
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“…Firstly, luzindole, a specific melatoninreceptor antagonist (31), could not block the melatonin's effects. In addition, it was previously demonstrated that the melatonin concentration needed to activate melatonin receptors is of the micromolar order (20,21,32). It was found in the present work, however, that the modulatory effects of melatonin were not observed at concentrations lower than 100 μM.…”
Section: Discussioncontrasting
confidence: 69%
“…Firstly, luzindole, a specific melatoninreceptor antagonist (31), could not block the melatonin's effects. In addition, it was previously demonstrated that the melatonin concentration needed to activate melatonin receptors is of the micromolar order (20,21,32). It was found in the present work, however, that the modulatory effects of melatonin were not observed at concentrations lower than 100 μM.…”
Section: Discussioncontrasting
confidence: 69%
“…No endogenous MLR activity was observed in cells only expressing D1 receptors and while 1/.tM forskolin stimulated the production of cAMP-100-fold over basal levels the addition of 100 nM ML resulted in an -30% decrease of forskolin stimulated cAMP accumulation in HEK-293 cells transiently expressing the cloned flcMLR (data not shown). Although it is unclear whether ML-and dopamine Dl-like receptors co-exist in the same neurons, evidence for functional ML and dopamine D1 receptor cross-talk regulating the activity of adenylate cyclase in cultured retinal cells has recently been documented [19,28]. The data on cloned receptors provide direct molecular evidence for the existence of functional ML-dopamine receptor interactions at the level of the single cell.…”
Section: Resultsmentioning
confidence: 99%
“…In the retina, ML inhibits dopamine synthesis and release [24] with a pharmacological profile and rank order of potency corresponding to the high-affinity ML~ receptor [25] found in either the rabbit retina or other neuronal and peripheral tissues from the same or different species ( [26,27] and see [2,13]). Moreover, in the retina, many opposing physiological and regulatory actions between dopamine and ML have been documented (see [28] and references therein). These interactions do not appear restricted to the retina, however, but may be evidenced as well in the hypothalamus and the pituitary gland where dopamine and ML regulate hormone release [29,30].…”
mentioning
confidence: 99%
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“…33,44 Both loss of the MT2 receptor and a decrease in melatonin are highly correlated with Alzheimer's disease, 12,14,15 and the cellular protection of melatonin or MT2 receptor activation has been well clarified. 45,46 Moreover, dopamine, 47 estrogen, 48 thyroid hormone, 49 acetylcholine, 50 glutamate, 51 GABA, 52 or their receptors 53 can affect or crosstalk with the melatonin/MT2 receptor, and most of these molecules have an important role in axonogenesis or synapse formation. [54][55][56][57] It remains unclear whether and how melatonin/MT2 receptor signaling interacts with these hormone and neurotransmitter systems in the brain, but it is conceivable that activation of the MT2 receptor could be a practical strategy to regenerate renascent axons from dendrites on mature neurons for the treatment of neurological diseases such as AD.…”
Section: Discussionmentioning
confidence: 99%