Functional interaction between morphine and central amygdala cannabinoid CB1 receptors in the acquisition and expression of conditioned place preference

Rezayof, Ameneh; Sardari, Maryam; Zarrindast, Mohammad‐Reza; Nayernouri, Touraj

doi:10.1016/j.bbr.2011.01.023

Cited by 30 publications

(15 citation statements)

References 53 publications

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“…The modulatory effects of the cannabinoid CB 1 receptor-selective agonist ACPA on brain reward systems were described many times. For example, ACPA influences conditioned place preference and conditioned place aversion (Rezayof et al 2011(Rezayof et al , 2012. Rezayof et al (2011) found that microinjection of ACPA into the central amygdala of rats (0.5, 2.5 and 5 ng/rat) potentiated morphine-induced (2 mg/kg) conditioned place preference in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Máchalová³

et al. 2014

Vet. Med. - Czech

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ABSTRACT:The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to produce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB 1 , CB 2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB 1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7 th to 13 th day of the experiment) were administered drugs as follows:(a) n 1 : vehicle at the dose of 10 ml/kg/day; (b) n 2 : Met at the dose of 2.5 mg/kg/day; (c) n 3 : ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1 st experimental day, (b) after the 1 st dose of drugs given on the 7 th day, and (c) on the 14 th day after the "challenge doses" administered in the following manner: n 1 : saline at a dose of 10 ml/kg, n 2, 3 : Met at a dose of 2.5 mg/kg. The observed behavioural changes consisted in: (a) gradual development of habituation to the open field conditions in three consecutive tests; (b) development of behavioural sensitisation to the stimulatory effects of Met after repeated treatment; (c) insignificant effect of repeated pre-treatment with ACPA on the stimulatory effects of Met challenge dose. The results of our study give rise to the question which of the cannabinoid receptor mechanisms might be most responsible for the neuroplastic changes inducing sensitisation to the stimulatory effects of Met. Keywords

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Section: Discussionmentioning

confidence: 99%

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Máchalová³

et al. 2014

Vet. Med. - Czech

View full text Add to dashboard Cite

show abstract

“…Then, animals were tested in a morphine-free state in order to eliminate the influence of morphine induced motor effects on responses (Olmstead and Franklin, 1997). Conditioning score and distance traveled were calculated for each rat Rezayof et al, 2011). In this experiment, morphine conditioned place preference paradigm was established by using a dose of morphine 5 mg/kg.…”

Section: Experimental Designmentioning

confidence: 99%

Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats

Roohi

Sarihi

Shahidi

et al. 2014

Pharmacology Biochemistry and Behavior

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“…Neither saline nor DMSO (dimethyl sulfoxide) used as the solvent led to a similar influence on the sensitising effects of morphine. Later, it was reported (Rezayof et al 2011) that microinjection of AM 251 into the central amygdala is sufficient to induce the phenomenon of conditioned place preference but inhibits the place preference to morphine. On the other hand, microinjection of ACPA into the central amygdala increased the extent of morphine-induced conditioned place preference.…”

Section: Discussionmentioning

confidence: 99%

Interaction of CB<sub>1</sub> receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice

Landa¹,

Šlais²,

Máchalová³

et al. 2014

Vet. Med. - Czech

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Activities of the endocannabinoid system are believed to be substantially involved in psychostimulant and opioid addiction. Nevertheless, interactions between cannabinoid and opioid systems are not yet fully understood. Thus, the aim of the present study was to investigate the interaction between morphine and the cannabinoid CB 1 receptor agonist arachidonylcyclopropylamide (ACPA) in behavioural sensitisation. Sensitisation occurs after repeated exposure to drugs of abuse including morphine and cannabinomimetics and it has been suggested to mediate craving and relapses. Male mice were randomly allocated into three groups and were seven times (from the 7 th to 13 th day of the experiment) administered drugs as follows: (a) n 1 : vehicle at the dose of 10 ml/kg/day; (b) n 2 : morphine at the dose of 10.0 mg/kg/day; (c) n 3 : ACPA at the dose of 1.0 mg/kg/day. Changes in locomotor behaviour were measured in the Open Field Test: (a) after administration of vehicle on the 1 st experimental day, (b) after the 1 st dose of drugs given on the 7 th day, and (c) on the 14 th day after "challenge doses" given in the following way: n 1 : saline at the dose of 10 ml/kg, n 2, 3 : morphine at the dose of 10.0 mg/kg. Registered behavioural changes unambiguously showed the development of behavioural sensitisation to the stimulatory effects of morphine on locomotion after its repeated administration (P < 0.05). However, surprisingly, taking into account reports on synergistic effects of opioids and cannabinoid receptor stimulation, a significant decrease (P < 0.05) in behavioural sensitisation to morphine occurred when the drug challenge dose was given following repeated pre-treatment with the CB 1 receptor agonist ACPA, i.e. suppression of cross-sensitisation to morphine. Keywords

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Functional interaction between morphine and central amygdala cannabinoid CB1 receptors in the acquisition and expression of conditioned place preference

Cited by 30 publications

References 53 publications

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats

Interaction of CB<sub>1</sub> receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice

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