2010
DOI: 10.1016/j.yebeh.2010.05.006
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Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice

Abstract: Stroke in the developing brain is an important cause of chronic neurological morbidities including neurobehavioral dysfunction and epilepsy. Here, we describe a mouse model of neonatal stroke resulting from unilateral carotid ligation that results in acute seizures, long-term hyperactivity, spontaneous lateralized circling behavior, impaired cognitive function and epilepsy. Explorationdependent induction of immediate early gene, Arc (activity-regulated cytoskeleton associated protein) in hippocampal neurons wa… Show more

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Cited by 20 publications
(20 citation statements)
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“…It is possible that the enhancement of neurogenesis found here, leading to 70% higher number of new mature neurons in the striatum at 33 days after the insult, is still too low to be translated into a behavioral improvement. Another possibility is that the behavioral assessments at 33 days after stroke were performed too early, since functional development and integration of the new neurons are not completed until 6 to 8 weeks, even several months, post-ischemia (Hou et al, 2008;Lai et al, 2008;Kadam et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that the enhancement of neurogenesis found here, leading to 70% higher number of new mature neurons in the striatum at 33 days after the insult, is still too low to be translated into a behavioral improvement. Another possibility is that the behavioral assessments at 33 days after stroke were performed too early, since functional development and integration of the new neurons are not completed until 6 to 8 weeks, even several months, post-ischemia (Hou et al, 2008;Lai et al, 2008;Kadam et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…However, most of our functional outcome measures were insensitive to the brain injury and therefore unable to assess response to treatment. We previously demonstrated in this model that newborn cells in the SGZ after stroke injury become mature dentate granule neurons, and a cell subset integrate into visual-spatial memory circuits after stroke [40]. However, additional work is needed to determine whether the increased SGZ cell proliferation in males, 9 days after stroke and 7 days after CBSC treatment, results in an increase in SGZ neurons, which mature and appropriately integrate.…”
Section: Detection Of Human Cells In Stroke-injured Brainsmentioning
confidence: 99%
“…However, additional work is needed to determine whether the increased SGZ cell proliferation in males, 9 days after stroke and 7 days after CBSC treatment, results in an increase in SGZ neurons, which mature and appropriately integrate. Because it takes about 3-4 weeks for newborn SGZ neurons that survive to migrate to the granule cell layer and manifest a high rate of glutamatergic synaptogenesis, Arc expression, and connectivity [40,41], future studies will determine whether the sex-dependent effects of cord blood-derived stem cells result in long-term cognitive improvements,…”
Section: Detection Of Human Cells In Stroke-injured Brainsmentioning
confidence: 99%
“…Hyperactivity is frequently associated with reduced neural activity or neuronal loss after brain injury (37)(38)(39)(40). We therefore next measured the expression of IEGs, including those for c-Fos, Zif268, Npas4, Arc, Homer1a, and Bdnf, in the brains of Shp2 cKO mice as an index of neuronal activity (41,42).…”
Section: Forebrain Neuron-specific Knockout Of the Shp2 Gene In Micementioning
confidence: 99%
“…Hyperactivity is often associated with a reduction in neuronal activity in both humans and animals (38)(39)(40). BDNF induces activation of Ras-MAPK signaling and a marked increase in synaptic transmission in mouse hippocampal slices (60), suggesting the importance of BDNF signaling in the regulation of neuronal activity.…”
Section: Rasmentioning
confidence: 99%