Functional ingredients and cardiovascular protective effect of pumpkin seed oils

Al‐Okbi, Sahar Y.; Mohamed, Doha A.; Kandil, Eman; Ahmed, Emad K.; Mohammed, Shaimaa

doi:10.3989/gya.062813

Cited by 11 publications

(11 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pumpkin seed oil used in the present study showed previously to contain 3.5% of oleic acid, 38.9% of linoleic acid and 5.8% of palmitic acid [Al-Okbi et al, 2014]. The same pumpkin seed oil contains stigmasterol and campesterol as 43.6% of unsaponifi able portion.…”

Section: Discussionmentioning

confidence: 91%

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Al‐Okbi¹,

Mohamed²,

Hamed³

et al. 2014

Pol. J. Food Nutr. Sci.

View full text Add to dashboard Cite

Key words: fatty liver, non-alcoholic fatty liver with infl ammation, fructose, rice bran oil, pumpkin seed oil Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease are increasing in adults and are likely to be increasing in children. The aim of the present research was to evaluate the protective effect of rice bran oil and pumpkin seed oil against high fructose diet (HFD) inducing nonalcoholic steatohepatitis (NASH). The results showed signifi cant elevation of plasma total and direct bilirubin, transaminases activities, total cholesterol (T-Ch), triglycerides (TG), low density lipoprotein-cholesterol (LDL-Ch), tumor necrosis factor- (TNF-) and malondialdehyde (MDA) with signifi cant increase in liver TG, T-Ch and MDA along with signifi cant reduction in plasma high density lipoprotein cholesterol (HDL-Ch) and increase in T-Ch/HDL-Ch in rats fed HFD compared to rats fed on balanced diet. Histopathology of liver of rats fed on HFD confi rmed the induction of NASH. Rice bran oil and pumpkin seed oil produced improvement in the biochemical parameters with different degrees. Pumpkin seed oil reversed all histopathological changes that occur in liver tissue which became comparable to normal in some rats. In conclusion, rats fed high fructose diet are a good model for studying NASH. Rice bran oil and pumpkin seed oil afford hepato protection against NASH in rat model.

show abstract

Section: Discussionmentioning

confidence: 91%

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Al‐Okbi¹,

Mohamed²,

Hamed³

et al. 2014

Pol. J. Food Nutr. Sci.

View full text Add to dashboard Cite

show abstract

“…The presence of α, δ and γ-tocopherol in PSO (Al-Okbi et al, 2014) could have a significant impact on improving the changes in AA rats. The phenolic content and the considerable concentration from both tocopherol and β-carotene in PSO may explain the antioxidant and anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

“…The present study showed the presence of phenolic compounds and beta-carotene in both varieties of PSOs. Also, the two varieties of PSOs were reported previously to contain phytosterols, unsaturated fatty acids, and tocopherols (Al-Okbi et al, 2014). These ingredients could collectively render the oils their antioxidant and anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

“…The pumpkin seed is among the plant foods that contain high levels of bioactive ingredients, including β-carotene, unsaturated fatty acids, phenolic compounds, phytosterols and tocopherols especially in the oil compartment. These functional food ingredients have been reported to possess both anti-inflammatory and antioxidant activities in hyper-cholesterolemic rats (Al-Okbi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…PSO was prepared from Egyptian pumpkin seeds by extraction using petroleum ether (40-60ºC) (Al-Okbi et al, 2014).…”

Section: Preparation Of Psomentioning

confidence: 99%

See 2 more Smart Citations

Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

et al. 2017

Self Cite

View full text Add to dashboard Cite

SUMMARY:The aim of the present research was to evaluate the anti-inflammatory activity of pumpkin seed oils (PSOs) of an Egyptian and European variety, in a rat model of adjuvant arthritis. Edema thickness, plasma tumor necrosis factor-α (TNF-α) and erythrocyte sedimentation rate (ESR) were determined as inflammatory biomarkers while malondialdehyde (MDA) and total antioxidant capacity (TAC) were assessed as indicative of oxidative stress. Chromosomal aberration, sperm shape abnormalities, and DNA fragmentations are cytogenetic parameters which aid in tracing inflammatory and oxidative activity. Phenolic contents and β-carotene were determined in PSOs. The results showed elevated ESR, plasma TNF-α, plasma MDA, liver cellular DNA fragmentation, bone marrow chromosomal aberration, sperm shape abnormalities with a reduction in plasma TAC and body weight gain in an adjuvant arthritis control compared to a healthy control. Administration of low and high doses of either Egyptian or European PSO improved all the aforementioned parameters with variable degrees.KEYWORDS: Adjuvant arthritis; Anti-inflammatory; β-Carotene; Phenolic contents; Pumpkin seed oils RESUMEN: Actividad antiinflamatoria de dos variedades de aceite de semillas de calabaza en un modelo de artritis adyuvante en ratas. El objetivo de la presente investigación fue evaluar la actividad antiinflamatoria de aceites de calabaza (PSOs) de variedades egipcia y europea, en un modelo de rata con artritis adyuvante. El espesor del edema, el factor de necrosis tumoral (TNF-α) y la velocidad de sedimentación eritrocitaria (ESR) se determinaron como biomarcadores inflamatorios, mientras que el malondialdehído (MDA) y la capacidad antioxidante total (TAC) fueron evaluados como indicativos de estrés oxidativo. La aberración cromosómica, las anomalías de la forma del esperma y las fragmentaciones del ADN son parámetros citogenéticos que ayudan a localizar la actividad inflamatoria y oxidativa. Se determinaron contenidos fenólicos y β-caroteno en PSOs. Los resultados mostraron elevado ESR, TNF-α plasmático, MDA plasmática, fragmentación del ADN del hígado, aberración cromosómica de la médula ósea, anomalías de la forma espermática con una reducción del TAC plasmático y un aumento del peso corporal en el control de la artritis adyuvante en comparación con el control sano. La administración de dosis bajas y altas de PSO egipcia o europea mejoró todos los parámetros mencionados en grados variables.

show abstract

Improvement effects of green tea and pumpkin oils on myelin oligodendrocyte glycoprotein-induced Multiple sclerosis in rats

Lamloum,

Soliman,

Rashad Ahmed

et al. 2023

Journal of Functional Foods

View full text Add to dashboard Cite

Functional ingredients and cardiovascular protective effect of pumpkin seed oils

Cited by 11 publications

References 64 publications

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

Improvement effects of green tea and pumpkin oils on myelin oligodendrocyte glycoprotein-induced Multiple sclerosis in rats

Contact Info

Product

Resources

About