Functional Improvement in Patients With Dilated Cardiomyopathy After the Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells

Lezo, José Suárez de; Herrera, Concepción; Romero, Miguel; Pan, Manuel; Lezo, Javier Suárez de; Carmona, MDolores; Jiménez, Rosario; Segura, José; Nogueras, Sonia; Mesa, Dolores; Pavlovic, Djordje; Ojeda, Soledad; Mazuelos, Francisco; Delgado, Mónica; Ruiz, Martín; Castilla, María Luisa Dotor; Torres, Antonio

doi:10.1016/j.rec.2012.11.013

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Various clinical outcomes have shown the regenerative capability of BMMNCs in subspecialties of medical fields such as plastic surgery, orthopedic surgery, oral and maxillofacial surgery, and cardiac surgery [35, 39, 40, 45]. These preliminary results suggest that BMMNCs-assisted lipotransfer could be effective and safe for soft tissue augmentation and superior to conventional lipoinjection.…”

Section: Discussionmentioning

confidence: 95%

Autologous Bone-Marrow-Derived-Mononuclear-Cells-Enriched Fat Transplantation in Breast Augmentation: Evaluation of Clinical Outcomes and Aesthetic Results in a 30-Year-Old Female

Bulgin¹,

Vrabic

Hodzic³

2013

Case Reports in Surgery

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Autologous fat transfer (lipofilling) is becoming an invaluable tool for breast augmentation as well as for breast reconstruction. Autologous lipofilling has several advantages, including biocompatibility, versatility, natural appearance, and low donor site morbidity. The main limitation is unpredictable fat graft resorption, which ranges from 25% to 80%, probably as a result of ischaemia and lack of neoangiogenesis. To obviate these disadvantages, several studies have searched for new ways of increasing the viability of the transplanted fat tissue. One promising approach is to enrich the fat graft with autologous bone-marrow-derived mononuclear cells (BMMNCs) before transplantation. BMMNCs produce many angiogenic and antiapoptotic growth factors, and their secretion is significantly enhanced by hypoxia. All of these mechanisms of actions could be beneficial for the stimulation of angiogenesis in ischemic tissues by BMMNCs administration. In our aesthetic surgery practice, we use fat transplantation enriched with BMMNCs, which caused a significant improvement in survival of fat grafts, compared with that of traditional lipofilling. Our experience with freshly isolated autologous fat enriched with BMMNCs for breast augmentation procedures is presented. The concept of this surgical and tissue handling technique is based on ability of BMMNCs to stimulate blood vessel growth.

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Section: Discussionmentioning

confidence: 95%

Autologous Bone-Marrow-Derived-Mononuclear-Cells-Enriched Fat Transplantation in Breast Augmentation: Evaluation of Clinical Outcomes and Aesthetic Results in a 30-Year-Old Female

Bulgin¹,

Vrabic

Hodzic³

2013

Case Reports in Surgery

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show abstract

“…Los ensayos clínicos en fase I y II concuerdan en señalar que la administración intracoronaria o intramiocárdica de células madre de diversos orígenes, en pacientes con insuficiencia cardiaca es segura [1][2][3][4][5][6][7] . Respecto a la eficacia de esta terapia, se han descrito beneficios significativos sobre la capacidad funcional, la calidad de vida y un aumento de la fracción de eyección del ventrículo izquierdo (FEVI) [1][2][3][4][5][6][7] . Pese a sugerir un beneficio importante dentro del primer año, es limitado el número de ensayos con seguimiento prolongado, en pacientes sometidos a terapia celular [4][5][6] .…”

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Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología

et al. 2015

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Intervencionismo percutáneo en cardiopatías congénitas. Cierre de defectos cardiacos y cortocircuitos

et al. 2014

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Functional Improvement in Patients With Dilated Cardiomyopathy After the Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells

Cited by 4 publications

References 35 publications

Autologous Bone-Marrow-Derived-Mononuclear-Cells-Enriched Fat Transplantation in Breast Augmentation: Evaluation of Clinical Outcomes and Aesthetic Results in a 30-Year-Old Female

Autologous Bone-Marrow-Derived-Mononuclear-Cells-Enriched Fat Transplantation in Breast Augmentation: Evaluation of Clinical Outcomes and Aesthetic Results in a 30-Year-Old Female

Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología

Intervencionismo percutáneo en cardiopatías congénitas. Cierre de defectos cardiacos y cortocircuitos

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