Functional implications of the CpG island methylation in the pathogenesis of celiac disease

Ghosh, Souparni; Khetarpal, Preeti; Senapati, Sabyasachi

doi:10.1007/s11033-022-07585-w

Cited by 5 publications

(3 citation statements)

References 93 publications

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“…With the improved epigenetic data, transcriptome data, metabolome, lipidome, genetic variants and microbiome studies, a comprehensive pathogenesis will be established. Regulation by epigenetic mechanisms and influencing the host GM play a key role in onset and progress of PD 128 . This will help understand DNA methylation at CpG islands 27 …”

Section: Discussionmentioning

confidence: 99%

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The connection between epigenetics and gut microbiota‐current perspective

Yuan,

Tan,

Bajinka

et al. 2024

Cell Biochemistry & Function

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Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics and potential therapeutic strategies for a number of diseases. These disorders include metabolic, central nervous system‐related diseases, autoimmune, and gastrointestinal infections (GI). Despite the number of studies, there is no extensive review that connects the epigenetics modifications and GM as biomarkers that could confer effective diagnostics and confer treatment options. To this end, this review hopes to give detailed information on connecting the modifications in epigenetic and GM. An updated and detailed information on the connection between the epigenetics factors and GM that influence diseases are given. In addition, the review showed some associations between the epigenetics to the maternal GM and offspring health. Finally, the limitations of the concept and prospects into this new emerging discipline were also looked into. Although this review elucidated on the maternal diet and response to offspring health with respect to GM and epigenetic modifications, there still exist various limitations to this newly emerging discipline. In addition to integrating complementary multi‐omics data, longitudinal sampling will aid with the identification of functional mechanisms that may serve as therapeutic targets. To this end, this review gave a detailed perspective into harnessing disease diagnostics, prevention and treatment options through epigenetics and GM.

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Section: Discussionmentioning

confidence: 99%

“…Regulation by epigenetic mechanisms and influencing the host GM play a key role in onset and progress of PD. 128 This will help understand DNA methylation at CpG islands. 27 The effects of PM exposure in relation to the outcomes of EM and alteration of GM in progression of disease is a prospect.…”

Section: The Prospectsmentioning

confidence: 99%

The connection between epigenetics and gut microbiota‐current perspective

Yuan,

Tan,

Bajinka

et al. 2024

Cell Biochemistry & Function

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“…During tumorigenesis, there is typically a decrease in the overall level of intracellular DNA methylation. However, there is abnormal elevation of DNA methylation in the CpG island regions of specific genes (Ghosh et al, 2022). This abnormal methylation pattern leads to genome-wide instability and altered gene expression profiles (Liang and Weisenberger, 2017).…”

Section: Dna Methylationmentioning

confidence: 99%

Research progress and applications of epigenetic biomarkers in cancer

Gao,

Shi,

Wang

et al. 2024

Front. Pharmacol.

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Epigenetic changes are heritable changes in gene expression without changes in the nucleotide sequence of genes. Epigenetic changes play an important role in the development of cancer and in the process of malignancy metastasis. Previous studies have shown that abnormal epigenetic changes can be used as biomarkers for disease status and disease prediction. The reversibility and controllability of epigenetic modification changes also provide new strategies for early disease prevention and treatment. In addition, corresponding drug development has also reached the clinical stage. In this paper, we will discuss the recent progress and application status of tumor epigenetic biomarkers from three perspectives: DNA methylation, non-coding RNA, and histone modification, in order to provide new opportunities for additional tumor research and applications.

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Genetic predisposition

Greco,

Auricchio

2024

Pediatric and Adult Celiac Disease

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Functional implications of the CpG island methylation in the pathogenesis of celiac disease

Cited by 5 publications

References 93 publications

The connection between epigenetics and gut microbiota‐current perspective

The connection between epigenetics and gut microbiota‐current perspective

Research progress and applications of epigenetic biomarkers in cancer

Genetic predisposition

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