Functional implications of neutrophil metabolism during ischemic tissue repair

Piccolo, Enzo; Thorp, Edward B.; Sumagin, Ronen

doi:10.1016/j.coph.2022.102191

Cited by 7 publications

(6 citation statements)

References 114 publications

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“…Then, we annotated these DEIRGs and found that they were mainly involved in the inflammatory response, leukocyte chemotaxis and migration, response to bacterium and other processes, and enriched in the apelin signaling pathway, IL-17 and IL-18 signaling pathway, neutrophil degranulation, TLRs cascades, and other pathways. Neutrophils, the most plentiful kind of leukocytes, play an important role during key cellular and molecular events of ICM ( 27 , 28 ). Neutrophil migration, chemotaxis, and degranulation are necessary for different pathological stages of ICM ( 27 , 28 ).…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophils, the most plentiful kind of leukocytes, play an important role during key cellular and molecular events of ICM ( 27 , 28 ). Neutrophil migration, chemotaxis, and degranulation are necessary for different pathological stages of ICM ( 27 , 28 ). IL-17 and 18, as pro-inflammatory cytokines, are up-regulated in patients with ICM and related to the New York Heart Association (NYHA) class ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

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Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

Wang

Xie

Cheng

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveInflammation plays an important role in the pathophysiology of ischemic cardiomyopathy (ICM). We aimed to identify potential biomarkers of inflammation-related genes for ICM and build a model based on the potential biomarkers for the diagnosis of ICM.Materials and methodsThe microarray datasets and RNA-Sequencing datasets of human ICM were downloaded from the Gene Expression Omnibus database. We integrated 8 microarray datasets via the SVA package to screen the differentially expressed genes (DEGs) between ICM and non-failing control samples, then the differentially expressed inflammation-related genes (DEIRGs) were identified. The least absolute shrinkage and selection operator, support vector machine recursive feature elimination, and random forest were utilized to screen the potential diagnostic biomarkers from the DEIRGs. The potential biomarkers were validated in the RNA-Sequencing datasets and the functional experiment of the ICM rat, respectively. A nomogram was established based on the potential biomarkers and evaluated via the area under the receiver operating characteristic curve (AUC), calibration curve, decision curve analysis (DCA), and Clinical impact curve (CIC).Results64 DEGs and 19 DEIRGs were identified, respectively. 5 potential biomarkers (SERPINA3, FCN3, PTN, CD163, and SCUBE2) were ultimately selected. The validation results showed that each of these five potential biomarkers showed good discriminant power for ICM, and their expression trends were consistent with the bioinformatics results. The results of AUC, calibration curve, DCA, and CIC showed that the nomogram demonstrated good performance, calibration, and clinical utility.ConclusionSERPINA3, FCN3, PTN, CD163, and SCUBE2 were identified as potential biomarkers associated with the inflammatory response to ICM. The proposed nomogram could potentially provide clinicians with a helpful tool to the diagnosis and treatment of ICM from an inflammatory perspective.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

Wang

Xie

Cheng

et al. 2022

Front. Cardiovasc. Med.

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“…Apart from ROS production, mitochondrial function regulates chemotaxis and mTOR signaling [ 65 , 66 ]. ATP release and mitochondrial purinergic signaling via P2Y2 receptor-mediated mTOR signaling are essential for neutrophil chemotaxis [ 67 , 68 ].…”

Section: Metabolism and Function Of Innate Immune Cell During Acute C...mentioning

confidence: 99%

The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective

2023

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Purpose of Review Recent technological advances have identified distinct subpopulations and roles of the cardiac innate immune cells, specifically macrophages and neutrophils. Studies on distinct metabolic pathways of macrophage and neutrophil in cardiac injury are expanding. Here, we elaborate on the roles of cardiac macrophages and neutrophils in concomitance with their metabolism in normal and diseased hearts. Recent Findings Single-cell techniques combined with fate mapping have identified the clusters of innate immune cell subpopulations present in the resting and diseased hearts. We are beginning to know about the presence of cardiac resident macrophages and their functions. Summary Resident macrophages perform cardiac homeostatic roles, whereas infiltrating neutrophils and macrophages contribute to tissue damage during cardiac injury with eventual role in repair. Prior studies show that metabolic pathways regulate the phenotypes of the macrophages and neutrophils during cardiac injury. Profiling the metabolism of the innate immune cells, especially of resident macrophages during chronic and acute cardiac diseases, can further the understanding of cardiac immunometabolism.

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“…Intravenous injection of 5–20 mg/kg forsythoside B dose-dependently reduced polymorph nuclear leukocyte (PMN) infiltration and myeloperoxidase (MPO) activity in a rat model of myocardial ischemia-reperfusion injury ( 7 ). The former releases inflammatory factors to damage cardiomyocytes after being activated by ischemic injury, while the latter is considered to be related to the occurrence of cardiovascular disease ( 8 , 9 ). High-mobility group box 1 (HMGB1) is an inflammatory mediator released by necrotic cells or activated innate immune cells and can activate the NF-κB signaling pathway ( 10 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Forsythiasides: A review of the pharmacological effects

Yang

Liu

Zhou

et al. 2022

Front. Cardiovasc. Med.

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Forsythiasides are a kind of phenylethanol glycosides existing in Forsythia suspensa (Thunb.) Vahl, which possesses extensive pharmacological activities. According to the different groups connected to the nucleus, forsythiasides can be divided into A-K. In recent years, numerous investigations have been carried out on forsythiasides A, B, C, D, E, and I, which have the effects of cardiovascular protection, anti-inflammation, anti-oxidation, neuroprotection, et al. Mechanistically, forsythiasides regulate toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor kappaB (NF-κB), nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) and other signaling pathways, as well as the expression of related cytokines and kinases. Further exploration and development may unearth more treatment potential of forsythiasides and provide more evidence for their clinical applications. In summary, forsythiasides have high development and application value.

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Functional implications of neutrophil metabolism during ischemic tissue repair

Cited by 7 publications

References 114 publications

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

Identification of potential biomarkers of inflammation-related genes for ischemic cardiomyopathy

The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective

Forsythiasides: A review of the pharmacological effects

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